Kinetics of Vascular Clearance of Particles by Phagocytes

Normann, Sigurd J.

doi:10.1007/978-1-4684-4574-9_4

Physiology 1984

DOI: 10.1007/978-1-4684-4574-9_4

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Kinetics of Vascular Clearance of Particles by Phagocytes

Sigurd J. Normann

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Cited by 3 publications

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“…Thus, for purely phagocytotic elimination of colloids Norman [3] has claimed partial inhibition between consecutive injections of particulate matter such as albumin particle, latex particles, red blood cells and carbon colloids. Neither did nanocoll given immediately before albures significantly influence the albures clearance rate constant.…”

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confidence: 99%

Vascular clearance by the reticuloendothelial system—measurements using two different-sized albumin colloids

Forssell-Aronsson

Gretarsdottir

et al. 1990

Scandinavian Journal of Clinical and Laboratory Investigation

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Normal and reticuloendothelial system (RES) stimulated rats were examined with dynamic liver RES scintigraphy using a computerized gamma camera. 99Tcm-labelled albumin colloid, albures (radius 250 nm) or nanocoll (radius 25 nm), or both were used as test substances to study the kinetics of vascular clearance after RES stimulation. Registrations were made of 30 s per frame for 5 min and 300 s per frame for 15 min or 25 min and a region of interest (ROI) was indicated over the liver. Whole body and liver RES clearance rate constants (k) were calculated from the liver uptake vs time curve. Liver parenchyma blood flow was estimated with 133Xe washout technique. The blood clearance rate constant of albures in non-activated rats was twice that for nanocoll (1.08 +/- 0.05 vs 0.49 +/- 0.02 10(-2)s-1). There was no mutual interaction between the two colloids, implying that they may be eliminated from the blood-stream by slightly different processes. In zymosan-stimulated animals, nanocoll given in a single injection showed a significantly increased k-value. Neither the albures clearance rate constant nor the nanocoll/albures k-value ratio revealed RES macrophage activation. By contrast the nanocoll/albures ratio, calculated for the liver, rose significantly. The final colloid uptake in the liver revealed RES macrophage activation. No changes in liver parenchyma blood flow per g tissue could be registered after administration of zymosan. The nanocoll and albures colloid particles did not impair the normal liver parenchyma blood flow.(ABSTRACT TRUNCATED AT 250 WORDS)

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confidence: 99%

Vascular clearance by the reticuloendothelial system—measurements using two different-sized albumin colloids

Forssell-Aronsson

Gretarsdottir

et al. 1990

Scandinavian Journal of Clinical and Laboratory Investigation

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Establishment of a multi-dose study of chondroitin sulfate iron colloid for evaluation of the reticuloendothelial system function

Ishida

Tsujinaka

Kido

et al. 1992

Journal of Biochemical and Biophysical Methods

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Dynamic Change of Reticuloendothelial System Function After Surgical Stress

Tsujinaka

Ishida

Kido

et al. 1993

J Parenter Enteral Nutr

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The influence of surgical stress on the function of the reticuloendothelial system (RES) is not well elucidated. Because we established an in vivo functional test for the RES by using chondroitin sulfate iron colloid in rabbits, the normal range of RES function in healthy volunteers (n = 12) and the dynamic change of RES function in surgical patients after distal gastrectomy (n = 14) were examined by this method. In healthy volunteers, the maximum phagocytic velocity and membrane-particle constant were 0.0310 +/- 0.0052 mg/kg per minute and 0.575 +/- 0.205 mg/kg, respectively. In surgical patients, maximum phagocytic velocity (postoperative day 1, 0.0408 +/- 0.0088; postoperative day 3, 0.0486 +/- 0.0115; and postoperative day 7, 0.0430 +/- 0.0115 mg/kg per minute) and membrane-particle constant (postoperative day 3, 0.717 +/- 0.169 mg/kg) significantly increased postoperatively in comparison with preoperative values. These results indicate that the total capacity of the RES is augmented but that its functional phagocytic efficiency is diminished after abdominal surgery. This phenomenon is considered to be one of the immunological alterations caused by surgical stress. The chondroitin sulfate iron colloid test can be applied to monitor the dynamic change of the RES function under various conditions.

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Kinetics of Vascular Clearance of Particles by Phagocytes

Cited by 3 publications

References 64 publications

Vascular clearance by the reticuloendothelial system—measurements using two different-sized albumin colloids

Vascular clearance by the reticuloendothelial system—measurements using two different-sized albumin colloids

Establishment of a multi-dose study of chondroitin sulfate iron colloid for evaluation of the reticuloendothelial system function

Dynamic Change of Reticuloendothelial System Function After Surgical Stress

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