Kinetics of post-treatment structural transformations of nitrogen plasma ion immersion implanted polystyrene

Kosobrodova, Elena; Kondyurin, Alexey; McKenzie, David R.; Bilek, M.M.M.

doi:10.1016/j.nimb.2013.03.038

Cited by 47 publications

(54 citation statements)

References 21 publications

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“…Coincidentally, the wCA measurements on PS and PC are the same within error (21 ± 4° and 25 ± 2°, respectively). During aging, both polymers undergo significant hydrophobic recovery, consistent with previous studies of PS and PC modification . Here, we find that PC is the least susceptible to hydrophobic recovery, yielding similar performance to HDPE.…”

Section: Resultssupporting

confidence: 91%

Evaluation of polymer hydrophobic recovery behavior following H₂O plasma processing

Tompkins

Fisher

2015

J of Applied Polymer Sci

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Inductively coupled radio frequency (rf) H 2 O vapor plasma was used to modify a range of polymers to better elucidate the dependence of hydrophobic recovery on polymer composition and structure. Freshly modified and aged samples were examined using scanning electron microscopy, (SEM), X-ray photoelectron spectroscopy, (XPS), and water contact angle (wCA) goniometry. Initially, wettability was increased on each polymer surface due to the implantation of polar oxide groups, an effect exacerbated by increased surface roughness with plasma treatment. Polypropylene and polystyrene exhibit nearly complete hydrophobic recovery as polar groups are subsumed as samples age. High-density polyethylene and polycarbonate exhibit minimal hydrophobic recovery, owing to plasma-induced cross-linking and intrinsic thermal stability, respectively. Overall, the hydrophobic performance following H 2 O plasma modification is similar to other oxidizing plasmas, suggesting that recovery behavior is intrinsic to the polymer. V C 2015Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41978.

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Section: Resultssupporting

confidence: 91%

Evaluation of polymer hydrophobic recovery behavior following H₂O plasma processing

Tompkins

Fisher

2015

J of Applied Polymer Sci

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“…biomolecules, including proteins such as tropoelastin [9]. PIII treatment significantly improves polymer wettability [12], thereby reducing denaturation of adsorbed proteins. The high concentration of radicals produced by PIII treatment in the polymer surface layer results in a significant increase of the polar component of surface free energy [12].…”

Section: Introductionmentioning

confidence: 99%

“…PIII treatment significantly improves polymer wettability [12], thereby reducing denaturation of adsorbed proteins. The high concentration of radicals produced by PIII treatment in the polymer surface layer results in a significant increase of the polar component of surface free energy [12]. Although hydrophobic recovery is observed after PIII treatment, the water contact angles of PIII-treated polymers typically do not reach the values measured before the treatment [13,14].…”

Section: Introductionmentioning

confidence: 99%

A sterilizable, biocompatible, tropoelastin surface coating immobilized by energetic ion activation

Yeo

Kondyurin

Kosobrodova

et al. 2017

J. R. Soc. Interface.

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Biomimetic materials which integrate with surrounding tissues and regulate new tissue formation are attractive for tissue engineering and regenerative medicine. Plasma immersion ion-implanted (PIII) polyethersulfone (PES) provides an excellent platform for the irreversible immobilization of bioactive proteins and peptides. PIII treatment significantly improves PES wettability and results in the formation of acidic groups on the PES surface, with the highest concentration observed at 40-80 s of PIII treatment. The elastomeric protein tropoelastin can be stably adhered to PIII-treated PES in a cell-interactive conformation by tailoring the pH and salt levels of the protein-surface association conditions. Tropoelastin-coated PIII-treated PES surfaces are resistant to molecular fouling, and actively promote high levels of fibroblast adhesion and proliferation while maintaining cell morphology. Tropoelastin, unlike other extracellular matrix proteins such as fibronectin, uniquely retains full bioactivity even after medical-grade ethylene oxide sterilization. This dual approach of PIII treatment and tropoelastin cloaking allows for the stable, robust functionalization of clinically used polymer materials for directed cellular interactions.

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“…PIII treatment is known to increase surface energy and hydrophilicity of polystyrene. Our previous intensive x‐ray photoelectron spectroscopy and fourier transform infrared spectroscopy analysis showed the presence of unpaired electrons and oxygen containing groups on the surface of PIII‐treated polystyrene . Finally, but most important, is the change of MPs surface charge after the PIII treatment.…”

Section: Resultsmentioning

confidence: 92%

“…Our previous intensive x-ray photoelectron spectroscopy and fourier transform infrared spectroscopy analysis showed the presence of unpaired electrons and oxygen containing groups on the surface of PIII-treated polystyrene. 14 Figure 2B). The high surface charge induces interparticle electrostatic repulsion facilitating colloidal stability of monodispersed particles in a suspension.…”

Section: Influence Of Piii Treatment On Mp Characteristicsmentioning

confidence: 95%

Covalent binding of molecules to plasma immersion ion implantation‐activated microparticles for delivery into cells

Kruse

Tran

Zandwijk

et al. 2020

Engineering Reports

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Delivery of biomolecules to target cells is an essential step in gene therapy, targeted drug delivery, and cell imaging, and can be achieved by encapsulation or conjugation to micro‐ or nanoparticles. For successful systemic delivery, these complexes must be stable under physiological conditions and prevent leakage of the cargo. Covalent binding of the active agent to a carrier is one‐way to facilitate this stability but frequently requires several steps. Here we show that plasma immersion ion implantation (PIII) treatment can activate the surface of paramagnetic polystyrene microparticles (MPs), increasing autofluorescence and allowing conjugation of biological molecules in a single‐step. Using PIII‐activated MPs, we demonstrate covalent binding of therapeutically relevant payloads including antibodies (Abs) and small‐interfering RNAs (siRNAs). The PIII‐activated magnetic particles were actively taken up by the cells, were nontoxic, and could be visualized due to increased autofluorescence induced by the PIII treatment. Ab and siRNA were effectively conjugated simultaneously to the active surface, and these functionalized MPs were also taken up by cells. This simple PIII‐based activation system has the potential to be applied to many different therapeutic approaches.

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Kinetics of post-treatment structural transformations of nitrogen plasma ion immersion implanted polystyrene

Cited by 47 publications

References 21 publications

Evaluation of polymer hydrophobic recovery behavior following H₂O plasma processing

Evaluation of polymer hydrophobic recovery behavior following H₂O plasma processing

A sterilizable, biocompatible, tropoelastin surface coating immobilized by energetic ion activation

Covalent binding of molecules to plasma immersion ion implantation‐activated microparticles for delivery into cells

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Kinetics of post-treatment structural transformations of nitrogen plasma ion immersion implanted polystyrene

Cited by 47 publications

References 21 publications

Evaluation of polymer hydrophobic recovery behavior following H2O plasma processing

Evaluation of polymer hydrophobic recovery behavior following H2O plasma processing

A sterilizable, biocompatible, tropoelastin surface coating immobilized by energetic ion activation

Covalent binding of molecules to plasma immersion ion implantation‐activated microparticles for delivery into cells

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Product

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Evaluation of polymer hydrophobic recovery behavior following H₂O plasma processing

Evaluation of polymer hydrophobic recovery behavior following H₂O plasma processing