2020
DOI: 10.1002/eng2.12087
|View full text |Cite
|
Sign up to set email alerts
|

Covalent binding of molecules to plasma immersion ion implantation‐activated microparticles for delivery into cells

Abstract: Delivery of biomolecules to target cells is an essential step in gene therapy, targeted drug delivery, and cell imaging, and can be achieved by encapsulation or conjugation to micro‐ or nanoparticles. For successful systemic delivery, these complexes must be stable under physiological conditions and prevent leakage of the cargo. Covalent binding of the active agent to a carrier is one‐way to facilitate this stability but frequently requires several steps. Here we show that plasma immersion ion implantation (PI… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
2

Relationship

2
0

Authors

Journals

citations
Cited by 2 publications
(1 citation statement)
references
References 36 publications
0
1
0
Order By: Relevance
“…The surface treatment with PIII is successful in reducing the contact angle and simultaneously enabling covalent binding of a wide range of biomolecules to carbon-backbone polymers. Examples of biomolecules with demonstrated covalent binding include catalase and poly-L-lysine bound to polyethylene [24], bone morphogenic protein and tropoelastin to PEEK [25], small-interfering RNAs to polystyrene microparticles [26], and melamine to polyvinyl chloride [27].…”
Section: Introductionmentioning
confidence: 99%
“…The surface treatment with PIII is successful in reducing the contact angle and simultaneously enabling covalent binding of a wide range of biomolecules to carbon-backbone polymers. Examples of biomolecules with demonstrated covalent binding include catalase and poly-L-lysine bound to polyethylene [24], bone morphogenic protein and tropoelastin to PEEK [25], small-interfering RNAs to polystyrene microparticles [26], and melamine to polyvinyl chloride [27].…”
Section: Introductionmentioning
confidence: 99%