Kinetics of long-term degradation of different molar mass hyaluronan solutions studied by SEC-MALLS

Simulescu, Vasile; Mondek, Jakub; Kalina, Michal; Pekař, Miloslav

doi:10.1016/j.polymdegradstab.2014.12.005

Cited by 19 publications

(13 citation statements)

References 18 publications

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“…The observed molar masses for the fresh hyaluronan solutions were lower than expected. The same tendency of molar mass loss was observed in our previous study on the long-term degradation of hyaluronic acid [30].…”

Section: Resultssupporting

confidence: 88%

“…We found that the dependence was non-linear, as we discovered in our previous study on the long-term degradation of hyaluronan samples [30]. In the same work, we presented new kinetic models for hyaluronan degradation.…”

Section: Kinetic Evaluation Of Hyaluronan Degradationsupporting

confidence: 71%

“…The lowest molar mass observed in our study was 79 kDa, for HA 1.8 MDa after thermal degradation for 9 h at 120 C. This value of molar mass was still high enough to obtain a random coil conformation. In our previous studies we observed the transition to a conformation between a random coil and a rod only for HA samples with a molar mass of 17 kDa [30]. In this case, the mass was too low to form a randomly coiled conformation.…”

Section: Resultsmentioning

confidence: 79%

“…In a previous work [30], we performed a time-dependent study of the degradation of hyaluronan solutions at room temperature (25 C) and in the refrigerator (4 C). Even at these temperatures, we observed molecular weight changes, and these were assigned to temperature degradation.…”

Section: Kinetic Evaluation Of Hyaluronan Degradationmentioning

confidence: 99%

See 3 more Smart Citations

Thermal degradation of high molar mass hyaluronan in solution and in powder; comparison with BSA

Mondek

Kalina

Simulescu

et al. 2015

Polymer Degradation and Stability

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Section: Resultssupporting

confidence: 88%

Section: Kinetic Evaluation Of Hyaluronan Degradationsupporting

confidence: 71%

Section: Resultsmentioning

confidence: 79%

Section: Kinetic Evaluation Of Hyaluronan Degradationmentioning

confidence: 99%

See 2 more Smart Citations

Thermal degradation of high molar mass hyaluronan in solution and in powder; comparison with BSA

Mondek

Kalina

Simulescu

et al. 2015

Polymer Degradation and Stability

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“…The gel is a solid jelly-like material that can have properties ranging from soft and weak to hard, with a lot of potential applications, from cosmetics (e.g., gels containing hyaluronic acid for skin [28][29][30], shower gels, and hair gels) to solar cells and even flame retardants [31].…”

Section: Introductionmentioning

confidence: 99%

New Hybrid Materials Synthesized with Different Dyes by Sol-Gel Method

Gheonea

Crasmareanu

Pleşu

et al. 2017

Advances in Materials Science and Engineering

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One well-known method for hybrids synthesis with incorporated organic dyes is sol-gel method, which is based on the concept of molecular manipulation to design ceramics, glasses, and composites. The low-temperature process allows for the incorporation of guest organic molecules within the inorganic matrix, as well as for the synthesis of hybrid networks in which the organic and inorganic phases are interpenetrating. The aim of the work presented in this paper was the preparation of the gels with three different dyes, at different molar ratios by using the hydrolytic sol-gel process. The interaction of the dye and the oxide was examined by UV-vis spectroscopy and FT-IR. The thermal stability of the hybrid organic-inorganic xerogel formed here was studied by thermal analysis. The micrographs obtained by scanning electron microscopy (SEM) revealed the high density of the films. Such characteristics indicate the possible application of these films in solar cells.

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Molar Mass Analysis of Hydrophobically Modified Hyaluronic Acid by SEC‐MALLS: Facing the Challenges of Amphiphilic Biomacromolecules

Botha

Kuntz

Moire

et al. 2018

Macro Chemistry & Physics

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A size exclusion chromatography–multiangle laser light scattering (SEC‐MALLS) method is developed for determining the molar masses of amphiphilic hyaluronan (HA), consisting of a hydrophilic polymer backbone modified to varying extents with hydrophobic, polymerizable acrylate groups. The polymers are prepared via the base‐catalyzed esterification of HA with acrylic anhydride. Various parameters are investigated including mobile phase composition, temperature, pH, salt type, and concentration in order to find the most suitable conditions for completely dissolving the modified polymers irrespective of the degree of substitution (DS), and for suppressing secondary polymer interactions. The hydrolytic and the thermal stability of the different materials at various experimental conditions are also extensively investigated. HAs with DS varying from 0 to 3.4 are subsequently analyzed at the optimized experimental conditions for the mobile phase being DMSO/H2O 60/40(v/v) with 0.05 M LiBr and an operating temperature of 40 °C. The refractive index increments (dn/dc) of the HAs are determined and the results show a dependence of dn/dc on DS.

show abstract

Kinetics of long-term degradation of different molar mass hyaluronan solutions studied by SEC-MALLS

Cited by 19 publications

References 18 publications

Thermal degradation of high molar mass hyaluronan in solution and in powder; comparison with BSA

Thermal degradation of high molar mass hyaluronan in solution and in powder; comparison with BSA

New Hybrid Materials Synthesized with Different Dyes by Sol-Gel Method

Molar Mass Analysis of Hydrophobically Modified Hyaluronic Acid by SEC‐MALLS: Facing the Challenges of Amphiphilic Biomacromolecules

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