Thermal degradation of high molar mass hyaluronan in solution and in powder; comparison with BSA

Mondek, Jakub; Kalina, Michal; Simulescu, Vasile; Pekař, Miloslav

doi:10.1016/j.polymdegradstab.2015.06.012

Cited by 30 publications

(19 citation statements)

References 21 publications

(21 reference statements)

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“…The gel is a solid jelly-like material that can have properties ranging from soft and weak to hard, with a lot of potential applications, from cosmetics (e.g., gels containing hyaluronic acid for skin [28][29][30], shower gels, and hair gels) to solar cells and even flame retardants [31].…”

Section: Introductionmentioning

confidence: 99%

New Hybrid Materials Synthesized with Different Dyes by Sol-Gel Method

Gheonea

Crasmareanu

Pleşu

et al. 2017

Advances in Materials Science and Engineering

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One well-known method for hybrids synthesis with incorporated organic dyes is sol-gel method, which is based on the concept of molecular manipulation to design ceramics, glasses, and composites. The low-temperature process allows for the incorporation of guest organic molecules within the inorganic matrix, as well as for the synthesis of hybrid networks in which the organic and inorganic phases are interpenetrating. The aim of the work presented in this paper was the preparation of the gels with three different dyes, at different molar ratios by using the hydrolytic sol-gel process. The interaction of the dye and the oxide was examined by UV-vis spectroscopy and FT-IR. The thermal stability of the hybrid organic-inorganic xerogel formed here was studied by thermal analysis. The micrographs obtained by scanning electron microscopy (SEM) revealed the high density of the films. Such characteristics indicate the possible application of these films in solar cells.

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Section: Introductionmentioning

confidence: 99%

New Hybrid Materials Synthesized with Different Dyes by Sol-Gel Method

Gheonea

Crasmareanu

Pleşu

et al. 2017

Advances in Materials Science and Engineering

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“…Since a large number of hydrogen bonds can be formed between the hydroxyl groups of HA and water 1 , it is speculated that when the temperature rises, the intermolecular hydrogen bonds need to be broken first, which increases the resistance to the vibration of water molecules. This result can be interpreted that the thermal stability of HA solution was achieved by the stability of water 35 and further provided an evidence of the biological protective function of carbohydrates in aqueous solutions by reducing the sensitivity of water to temperature [36][37][38] .…”

Section: Discussionmentioning

confidence: 61%

Understanding hyaluronic acid induced variation of water structure by near-infrared spectroscopy

Dong

Guo²,

et al. 2020

Sci Rep

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In order to understand the hydration effect of hyaluronic acid (HA) in aqueous solution, near-infrared (NIR) spectroscopy was used to investigate the HA aqueous solutions at different concentrations and temperature. As HA concentration was raised, there was a nonlinear change in absorption value in the first overtone region of OH, indicating the changes of hydration water. A reconstructed spectrum based on principal component analysis (PCA) was established and analyzed with the concept of aquaphotomics. The results showed that HA acted as a structure maker to make water molecules arranged in order. Water species with two hydrogen bonds (S 2 ) and three hydrogen bonds (S 3 ) showed the decrease at low concentration range of 0-40 mg/mL, but increased at higher concentration, indicating the difference in water species at different HA concentration. Meanwhile, HA had the ability to improve the thermal stability of water structure, suggesting a potential bio-protective function. this study provides a unique perspective on the molecular interactions between HA and water molecules, which is helpful for understanding the role of HA in life process and may serve as the basis for HA applications.Hyaluronic acid (HA) is a natural polysaccharide and one of the main component of the extracellular matrix 1 . It is widely distributed in various tissues and organs of animals as well as the capsules of some bacteria, and plays a significant role in life process 1 . Due to its high water retaining capacity, biocompatibility and non-immunogenicity, HA is an attractive material for various cosmetic, food and medical applications 2-4 .It is known that the structure and morphology of polysaccharides are strongly influenced by water molecules via controlling their conformations, various forms of aggregation, thermal properties and kinetics 5,6 . In this respect, the knowledge of the interaction between water and polysaccharide and the hydrated structure is of high importance for understanding its performance in the application. Studies on HA hydration have been reported by using various experimental techniques, including nuclear magnetic resonance (NMR) 7 , viscometry 8 , ultrasonic and densitometry analyses 9 , thermal analysis 10,11 , spectroscopic techniques 12-14 , and by means of computer simulations 15 . A complex relationship between HA and water molecules was partly discovered that the macroscopic properties of HA are significantly dependent on its degree of hydration and the function of HA relies on the hydration capacity 4,16-18 .Analysis of the hydration water in aqueous solution is challenging, and the structural changes in water induced by HA are yet to be fully understood. Near-infrared (NIR) spectroscopy, as a powerful analytical method, has unique advantages in studies of molecular structure and interaction [19][20][21][22] . It mainly reflects the overtones and combination modes of functional groups containing hydrogen atoms, such as CH, OH and NH, which play a significant role in chemical bonding and other chemical ph...

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“…[24][25][26] In acidic condition, hydrolysis reaction occurs on the glucuronic acid and the hemiacetal ring moieties in the polymer. Hydrolysis also occurs on the N-acetylglucosamine residue in basic solution, following first-order reaction kinetics.…”

Section: Resultsmentioning

confidence: 99%

Formulation and Analgesic Effect of Sodium Hyaluronate and Magnesium Sulfate Combination in Rats Following Intra‐articular Injection

Lee

Jung

et al. 2017

Bulletin Korean Chem Soc

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The objective of this study was to formulate hyaluronate (HA) combined with magnesium sulfate (MS) for intra-articular (IA) injection, to provide rapid and profound analgesia in the treatment of osteoarthritis (OA). The injectable HA/MS combination was optimized with respect to the kinds and amounts of buffering agent (10 mM histidine, pH 7.0) and stabilizer (10 mM sodium citrate), by evaluating changes in the appearance, pH, and intrinsic viscosity at 60 C. Increasing concentrations of sodium citrate significantly inhibited the decline in intrinsic viscosity, denoting the depolymerization of HA, preserving over 91% of initial value. In an efficacy study in iodoacetate-induced OA rats, treatment with the HA/MS combination (1/2% w/v) significantly reduced joint swelling and pain, compared to the vehicle-and HA-treated groups (p < 0.05) at 7 days postdosing. Thus, IA administration of the combination of HA, a slow-acting symptom-modifying agent, with the inorganic analgesic is a potentially effective therapeutic approach for rapid pain relief in the OA knee.

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Thermal degradation of high molar mass hyaluronan in solution and in powder; comparison with BSA

Cited by 30 publications

References 21 publications

New Hybrid Materials Synthesized with Different Dyes by Sol-Gel Method

New Hybrid Materials Synthesized with Different Dyes by Sol-Gel Method

Understanding hyaluronic acid induced variation of water structure by near-infrared spectroscopy

Formulation and Analgesic Effect of Sodium Hyaluronate and Magnesium Sulfate Combination in Rats Following Intra‐articular Injection

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