Kinetics of humoral antibody response to trivalent inactivated split influenza vaccine in subjects previously vaccinated or vaccinated for the first time

Künzel, W

doi:10.1016/0264-410x(96)00061-8

Cited by 89 publications

(57 citation statements)

References 13 publications

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“…Furthermore, high antibody titres have been shown to prevent disease whereas lower titres modify disease severity. 1,26,27 In adults, neutralising antibodies to HA appear within about 7 days. Given that the majority will have been previously exposed to the same or similar epitopes through earlier infection, this is the response of primed individuals so the time to respond in na€ ıve children may be different and presumably longer.…”

Section: Influenza Vaccinesmentioning

confidence: 99%

“…Given that the majority will have been previously exposed to the same or similar epitopes through earlier infection, this is the response of primed individuals so the time to respond in na€ ıve children may be different and presumably longer. 27 The duration of antibody response is difficult to determine as this is influenced by prior immunisation with common epitopes and asymptomatic infection post vaccination. In children, approximately 60% of those who responded had detectable antibody 10-15 months later compared with 91% of adults.…”

Section: Influenza Vaccinesmentioning

confidence: 99%

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Evaluating the case for trivalent or quadrivalent influenza vaccines

Baxter

2016

Human Vaccines & Immunotherapeutics

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Influenza viruses circulate widely throughout the world and it is estimated that they affect between 5 and 15% of the population annually. Since 1977, four viruses co-circulate -two A Viruses (H1N1 and H3N2) and two B viruses (B Yamagata and B Victoria). Type A viruses generally cause up to two thirds of annual infections, although single country studies have shown that B infections may be the predominant virus in the one year in four.Influenza vaccines have traditionally included the hamagglutinins and neuraminidases from the two circulating A viruses and either B Yamagata or B Victoria -however, selecting the B strain for inclusion in these trivalent vaccines has variable success. The alternative approach is to include both B strains in a quadrivalent vaccine. Immunological studies of such vaccines show non-inferiority with a trivalent vaccine comparator, and significant superiority to the additional B strain.Quadrivalent vaccines are more expensive than trivalent preparations but theoretical evidence would suggest they are likely to be more effective and therefore play a much greater role in national immunisation programmes in the future.

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Section: Influenza Vaccinesmentioning

confidence: 99%

Section: Influenza Vaccinesmentioning

confidence: 99%

Evaluating the case for trivalent or quadrivalent influenza vaccines

Baxter

2016

Human Vaccines & Immunotherapeutics

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“…With this criterion, a large proportion of our study population did not respond to the vaccination, although the population excluded individuals with major comorbidity. Immunogenicity may vary between influenza virus vaccine strains, and indeed A/Texas/36/91 has been described as poorly immunogenic (16,21,37). Therefore, it cannot be excluded that elderly individuals may have a better response to other vaccine strains.…”

Section: Cd28mentioning

confidence: 99%

Value of Immunological Markers in Predicting Responsiveness to Influenza Vaccination in Elderly Individuals

Goronzy¹,

Fulbright²,

Crowson

et al. 2001

J Virol

373

294

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Elderly individuals are at high risk for morbidity and mortality when infected with influenza virus. Vaccinations with inactivated virus are less effective in the elderly due to the declining competency of the aging immune system. We have explored whether immunological parameters predict poor anti-influenza virus vaccine responses and can be used as biological markers of immunosenescence. One hundred fifty-three residents of community-based retirement facilities aged 65 to 98 years received a trivalent influenza vaccine. Vaccine-induced antibody responses were determined by comparing hemagglutination inhibition titers before and 28 days after immunization. The composition of the T-cell compartment was analyzed by flow cytometry and the sizes of three T-cell subsets, CD4؉ CD45RO ؉ cells, CD4 ؉ CD28 null cells, and CD8 ؉ CD28 null cells, were determined. Only 17% of the vaccine recipients were able to generate an increase in titers of antibody to all three vaccine components, and 46% of the immunized individuals failed to respond to any of the three hemagglutinins. The likelihood of successful vaccination declined with age and was independently correlated with the expansion of a particular T-cell subset, CD8؉ CD28 null T cells. The sizes of the CD4 ؉ CD45RO؉ memory T-cell and CD4 ؉ CD28 null T-cell subsets had no effect on the ability to mount anti-influenza virus antibody responses. Frequencies of CD8 ؉ CD28 null T cells are useful biological markers of compromised immunocompetence, identifying individuals at risk for insufficient antibody responses.

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“…PTSD patients produced a significant antibody response after influenza vaccination, indicating that low prevaccination antibody titres are associated with higher humoral immune response induced by vaccine. A previous study showed that subjects vaccinated for the first time had higher response rates and antibody increase than those previously vaccinated [27].…”

Section: Discussionmentioning

confidence: 92%

Outcome of influenza vaccination in combat-related post-traumatic stress disorder (PTSD) patients

Krnić

Gagro

Kozarić‐Kovačić

et al. 2007

Clinical and Experimental Immunology

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SummaryPost-traumatic stress disorder (PTSD) is an anxiety disorder that can occur after exposure to extreme traumatic experience such as war trauma, and is accompanied by fear, helplessness or horror. Exposure to trauma can result in immune dysregulation and influence susceptibility to infectious disease as well as vaccine efficacy. The aim of the study was to determine the relation of psychological stress and the immune response to influenza vaccination in combat-related PTSD patients (n = 28). Detection of anti-viral antibody titre was performed by inhibition of haemagglutination assay. Ex vivo tetramer staining of CD8 + T lymphocytes was used to monitor T cells specific for human leucocyte antigen (HLA)-A*0201-restricted influenza A haemagglutinin antigens before and after vaccination. Twenty patients showed a fourfold antibody titre increase to one or both influenza A viral strains, and 18 of them showed the same response for both influenza B viral strains. Ten of 15 healthy controls showed a fourfold rise in antibody titre to both influenza A viral strains and eight of them showed the same response for both influenza B viral strains. HLA-A*0201 + PTSD patients (n = 10) showed a significant increase of influenza-specific CD8 T cells after vaccination. Although those PTSD patients had a lower number of influenza-specific CD8 + T cells before vaccination compared to HLA-A*0201 + healthy controls (n = 6), there was no difference in influenza A antibody titre between PTSD patients and control subjects before vaccination. The generated humoral and cellular immune response in PTSD patients argues against the hypothesis that combat-related PTSD in war veterans might affect protection following influenza vaccination.

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Kinetics of humoral antibody response to trivalent inactivated split influenza vaccine in subjects previously vaccinated or vaccinated for the first time

Cited by 89 publications

References 13 publications

Evaluating the case for trivalent or quadrivalent influenza vaccines

Evaluating the case for trivalent or quadrivalent influenza vaccines

Value of Immunological Markers in Predicting Responsiveness to Influenza Vaccination in Elderly Individuals

Outcome of influenza vaccination in combat-related post-traumatic stress disorder (PTSD) patients

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