Kinetics of collagen microneedle drug delivery system

Aditya, Abhilash; Kim, Beomjin; Koyani, Rina D.; Oropeza, Beu P.; Furth, Michael E.; Kim, Jihye; Kim, Nam-Soo

doi:10.1016/j.jddst.2019.03.007

Cited by 24 publications

(10 citation statements)

References 19 publications

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“…In addition, Col nanoparticles enhance the delivery of certain drugs such as camptothocin, tetracycline, doxycicline, rolitetracycline, minocycline, amikacin, tobramycin, vancomycin, etc., into the systemic circulation due to its penetration ability into colloidal solution [ 112 ]. Conversely, the kinetics in a Col biomaterial are usually influenced by the physical processes, such as swelling to form a gel, polymer hydration via fluid, drug diffusion through the gel formed and eventual erosion of the polymeric gel [ 113 ]. For example, the polymer undergoes a relaxation process in an aqueous media, resulting in direct, gradual erodation of the hydrated polymer.…”

Section: Collagen As a Drug Carrier In The Pharmaceutical Industrymentioning

confidence: 99%

Natural-Based Biomaterial for Skin Wound Healing (Gelatin vs. Collagen): Expert Review

et al. 2021

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Collagen (Col) and gelatin are most extensively used in various fields, particularly in pharmaceuticals and therapeutics. Numerous researchers have proven that they are highly biocompatible to human tissues, exhibit low antigenicity and are easy to degrade. Despite their different sources both Col and gelatin have almost the same effects when it comes to wound healing mechanisms. Considering this, the bioactivity and biological effects of both Col and gelatin have been, and are being, constantly investigated through in vitro and in vivo assays to obtain maximum outcomes in the future. With regard to their proven nutritional values as sources of protein, Col and gelatin products exert various possible biological activities on cells in the extracellular matrix (ECM). In addition, a vast number of novel Col and gelatin applications have been discovered. This review compared Col and gelatin in terms of their structures, sources of derivatives, physicochemical properties, results of in vitro and in vivo studies, their roles in wound healing and the current challenges in wound healing. Thus, this review provides the current insights and the latest discoveries on both Col and gelatin in their wound healing mechanisms.

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Section: Collagen As a Drug Carrier In The Pharmaceutical Industrymentioning

confidence: 99%

Natural-Based Biomaterial for Skin Wound Healing (Gelatin vs. Collagen): Expert Review

et al. 2021

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“…This model was found to be more precise in figuring out the therapeutic results and dynamics of the drug transport agents in vivo, and in the demonstration of tumor biology, which fastens the drug discovery for cancer therapy [75]. Studies have also demonstrated that collagen NPs have been utilised as parenteral carriers for therapeutic and cytotoxic substances, such as hydrocortisone (Berthold et al) and camptothecin (Yang et al) [8,76,77] These investigations on collagen in DDS are summarized in Table 2.…”

Section: Collagen Based Nps In Ddsmentioning

confidence: 99%

“…Collagen can also form complexes with different biologically active and medical substances [7]. Some of the applications of collagen are the formation of microspheres and microneedles for drug delivery [8], formulation of NPs for gene delivery [9], development of pellets and tablets for protein delivery [10], formation of gels and combination with liposomes for sustained drug delivery [11], cancer treatment [12] and collagen shields in ophthalmology [13]. The collagen types that can be purified and isolated for usage in pharmaceutical industries for drug delivery are: (i) Enzyme and alkali treated collagen, (ii) natural salt-soluble collagen, (iii) insoluble collagen and (iv) acid-soluble collagen [14].…”

Section: Introductionmentioning

confidence: 99%

Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

et al. 2021

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The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

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“…This promotion of an electron causes energy to be used and therefore absorption occurs. 168 Aditya et al 169 used UV-Vis spectroscopy to observe the dissolution of collagen-PVP-MNs doped with trypan blue, a model drug. The DMNs were dissolved in deionised (DI) water or 0.8% NaCl and UV-Vis was used to measure the dye release every 20 seconds.…”

Section: Drug Release and Activitymentioning

confidence: 99%