Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

Arun, Ashni; Malrautu, Pratyusha; Laha, Anindita; Luo, Hongrong; Ramakrishna, Seeram

doi:10.3390/app112311369

Cited by 47 publications

(17 citation statements)

References 93 publications

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“…Nano collagen can be used for a variety of improvements and treatments, such as bone grafting, drug delivery, nerve tissue formation, vascular grafting, articular cartilage regeneration, cosmetics, and wound healing [ 21 , 22 , 36 ]. It is clear that nano collagen is a progressed type of nanotechnology; thus, further investigation must be attempted to advance this technology with the expectation that, in the future, nano collagen scaffolds will be more widely available [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

Collagen Derived from Fish Industry Waste: Progresses and Challenges

Rajabimashhadi

Gallo

Salvatore³

et al. 2023

Polymers

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Fish collagen garnered significant academic and commercial focus in the last decades featuring prospective applications in a variety of health-related industries, including food, medicine, pharmaceutics, and cosmetics. Due to its distinct advantages over mammalian-based collagen, including the reduced zoonosis transmission risk, the absence of cultural-religious limitations, the cost-effectiveness of manufacturing process, and its superior bioavailability, the use of collagen derived from fish wastes (i.e., skin, scales) quickly expanded. Moreover, by-products are low cost and the need to minimize fish industry waste’s environmental impact paved the way for the use of discards in the development of collagen-based products with remarkable added value. This review summarizes the recent advances in the valorization of fish industry wastes for the extraction of collagen used in several applications. Issues related to processing and characterization of collagen were presented. Moreover, an overview of the most relevant applications in food industry, nutraceutical, cosmetics, tissue engineering, and food packaging of the last three years was introduced. Lastly, the fish-collagen market and the open technological challenges to a reliable recovery and exploitation of this biopolymer were discussed.

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Section: Introductionmentioning

confidence: 99%

Collagen Derived from Fish Industry Waste: Progresses and Challenges

Rajabimashhadi

Gallo

Salvatore³

et al. 2023

Polymers

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“…It accounts for more than 30% of all body proteins. Due to numerous advantages such as biocompatibility, biodegradability, non-immunogenicity, non-toxicity, tensile strength, low antigenicity, extensibility, and accessibility, it plays an essential role in the synthesis of nanoparticles in various biomedical fields, especially in drug delivery and tissue engineering [ 136 , 137 , 138 ]. Biodegradable and thermally stable collagen nanoparticles are suitable nanocarriers for many therapeutic and cytotoxic substances, genes, proteins, growth factors, and drugs.…”

Section: Animal-based Biopolymeric Nanoparticles Used For Healthcare ...mentioning

confidence: 99%

“…In dermatology, for example, they are important for administering antimicrobials and steroids. They have good absorption capacity, large contact surface area, and ensure controlled and long-term release of drugs [ 136 , 139 , 140 ].…”

Section: Animal-based Biopolymeric Nanoparticles Used For Healthcare ...mentioning

confidence: 99%

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Kučuk

Primožič

Knez

et al. 2023

IJMS

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Biopolymeric nanoparticles are gaining importance as nanocarriers for various biomedical applications, enabling long-term and controlled release at the target site. Since they are promising delivery systems for various therapeutic agents and offer advantageous properties such as biodegradability, biocompatibility, non-toxicity, and stability compared to various toxic metal nanoparticles, we decided to provide an overview on this topic. Therefore, the review focuses on the use of biopolymeric nanoparticles of animal, plant, algal, fungal, and bacterial origin as a sustainable material for potential use as drug delivery systems. A particular focus is on the encapsulation of many different therapeutic agents categorized as bioactive compounds, drugs, antibiotics, and other antimicrobial agents, extracts, and essential oils into protein- and polysaccharide-based nanocarriers. These show promising benefits for human health, especially for successful antimicrobial and anticancer activity. The review article, divided into protein-based and polysaccharide-based biopolymeric nanoparticles and further according to the origin of the biopolymer, enables the reader to select the appropriate biopolymeric nanoparticles more easily for the incorporation of the desired component. The latest research results from the last five years in the field of the successful production of biopolymeric nanoparticles loaded with various therapeutic agents for healthcare applications are included in this review.

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“…In regenerative processes, collagen-based biomatrix imitates scaffolds that fulfill structural and mechanical functions thus favoring the reconstruction of damaged organs and tissues. Importantly, the introduction of collagen into composite biomaterials increases the effectiveness of such materials in regenerative processes, their ability to combine with growth factors, and also enables intracellular transmission and stabilization of cellular components due to which such composite plays a role of a physical structure supporting the regeneration processes [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Investigations on the Influence of Collagen Type on Physicochemical Properties of PVP/PVA Composites Enriched with Hydroxyapatite Developed for Biomedical Applications

et al. 2021

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Nowadays, a great attention is directed into development of innovative multifunctional composites which may support bone tissue regeneration. This may be achieved by combining collagen and hydroxyapatite showing bioactivity, osteoconductivity and osteoinductivity with such biocompatible polymers as polyvinylpyrrolidone (PVP) and poly(vinyl alcohol) (PVA). Here PVA/PVP-based composites modified with hydroxyapatite (HAp, 10 wt.%) and collagen (30 wt.%) were obtained via UV radiation while two types of collagen were used (fish and bovine) and crosslinking agents differing in the average molecular weight. Next, their chemical structure was characterized using Fourier transform infrared (FT-IR) spectroscopy, roughness of their surfaces was determined using a stylus contact profilometer while their wettability was evaluated by a sessile drop method followed by the measurements of their surface free energy. Subsequently, swelling properties of composites were verified in simulated physiological liquids as well as the behavior of composites in these liquids by pH measurements. It was proved that collagen-modified composites showed higher swelling ability (even 25% more) compared to unmodified ones, surface roughness, biocompatibility towards simulated physiological liquids and hydrophilicity (contact angles lower than 90°). Considering physicochemical properties of developed materials and a possibility of the preparation of their various shapes and sizes, it may be concluded that developed materials showed great application potential for biomedical use, e.g., as materials filling bone defects supporting their treatments and promoting bone tissue regeneration due to the presence of hydroxyapatite with osteoinductive and osteoconductive properties.

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Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

Cited by 47 publications

References 93 publications

Collagen Derived from Fish Industry Waste: Progresses and Challenges

Collagen Derived from Fish Industry Waste: Progresses and Challenges

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Investigations on the Influence of Collagen Type on Physicochemical Properties of PVP/PVA Composites Enriched with Hydroxyapatite Developed for Biomedical Applications

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