Kinetics of cadmium accumulation and elimination in carp Cyprinus carpio tissues

Cinier, C. De Conto; Petit‐Ramel, M.; Faure, R.; Garín, Daniel; Bouvet, Yvette

doi:10.1016/s0742-8413(98)10132-9

Cited by 42 publications

(34 citation statements)

References 40 publications

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“…Even at sub-lethal concentrations, cadmium has a cumulative effect and causes serious physiologic disturbances in fish, such as anorexia as well as effects on the blood cells (Witeska, 1998;Cicik & Engin, 2005). Particular attention, therefore, must be focused on fish because of their high affinity for cadmium (De Conto Cinier et al, 1999). Lead (Pb) is a non-essential and non-beneficial element known to alter the haematologic system of hosts by inhibiting the activities of some enzymes involved in heme biosynthesis (ATSDR, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Concerning public health issues, cadmium contamination of food is of critical significance as cadmium is involved in enduring health problems. Moreover, C. carpio have the ability to accumulate and concentrate cadmium to levels several orders of magnitude above those found in their environment (De Conto Cinier et al, 1999). Accordingly, because data are scarce and, in some cases, conflicting, this study aimed at determining changes in the histology of common carp's gill tissue following exposure to sub-lethal amounts of cadmium and lead.…”

Section: Introductionmentioning

confidence: 99%

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Haematological, blood biochemical and histopathological effects of sublethal cadmium and lead concentrations in common carp

Khalesi¹,

Abedi²,

Behrouzi³

et al. 2017

BJVM

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, 2017. Haematological, blood biochemical and histopathological effects of sublethal cadmium and lead concentrations in common carp. Bulg. J. Vet. Med., 20, No 2,[141][142][143][144][145][146][147][148][149][150] The present research aimed at examining the effects of common carp (Cyprinus carpio) exposure to sublethal concentrations of two non-essential heavy metals: cadmium (Cd: 8.4 mg/L) and lead (Pb: 6.2 mg/L) for 15 days to evaluate occurring biochemical and haematological effects. The examined parameters included haematocrit (Hct), haemoglobin (Hb), lymphocytes (Lym), neutrophils (Neu), total protein (TP), albumin (Alb), immunoglobulin M (IgM), glucose, red and white blood cells counts (RBC & WBC), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), and mean corpuscular haemoglobin concentration (MCHC). Exposure to both metals significantly (P<0.05) reduced the amounts of WBC and MCHC. MCV values decreased (P<0.05) after the Pb treatment but MCV estimates with Cd exposure showed no differences. MCH levels increased in both treatments (P<0.05) whereas Hct, Hb, RBC, Lym, and Neu following both metal exposures were almost similar to those in the control. IgM values were elevated in fish contaminated with both Pb and Cd (P<0.05). The exposed fish showed fusion of gill lamellae, vessel dilatation, hyperaemia, and hyperplasia of gill epithelial cells whereas muscle histology remained unchanged. The observed responses can be secondary to low heavy metals concentrations reflecting the trigger of stress reactions in affected fish.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Haematological, blood biochemical and histopathological effects of sublethal cadmium and lead concentrations in common carp

Khalesi¹,

Abedi²,

Behrouzi³

et al. 2017

BJVM

View full text Add to dashboard Cite

show abstract

“…Considerable quantity of Cd will be accumulated in various tissues of fishes in aquatic environment, and it is based on style of exposure, diet or waterborne. Yet accumulation of Cd in fish muscle was rarely reported though it can pose severe impact on fish without any visible signs [8,9]. Because of bio magnification of Cd in food chain, when consumed by human, it will become a more important subject for aquatic science [10].…”

Section: Introductionmentioning

confidence: 99%

Cadmium Accumulation and Its Histological Effect on Brain and Skeletal Muscle of Zebrafish

Sawafi¹,

Wang²,

Yan³

2017

J Heavy Met Toxicity Dis

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Acute toxicity of cadmium (Cd) to zebrafish (Danio rerio) was studied. The 24, 48, 72 and 96 h LC50 values (with 95% confidence limits) estimated by probit analysis were 16.73 (20.03-13.98), 12.88 (14.96-11.08), 11.46 (13.21-9.94), 9.68 (11.12-8.43) mg L -1 , respectively. To determine the accumulation and cyto-toxicity of Cd on the brain and skeletal muscle of zebrafish, specimens of zebrafish were exposed to three concentrations of cadmium (0.65 mg Cd L -1 , C1; 0.97 mg Cd L -1 , C2; and 1.94 mg Cd L -1 , C3 (corresponding to 1/15th, 1/10th and 1/5th of 96 h LC50), respectively for 25 days. The concentration of Cd in the fish tissue was detected by Inductively Coupled Plasma Mass Spectrometer (ICP-MS). Tissue alterations of brain and skeletal muscle were observed under light microscope. Cadmium concentrations of the treated fishes showed a significantly exponential increase over time and peaked at Day 25. In term of histomorphology of brain and skeletal muscle, obvious tissue chaos was noticed in the treated fishes compared to the control group. This mess clearly appeared at Day 25 at C3 in the brain where the tissue showed different extents of granule cell loss, degeneration of Purkinje cells, aggregation area of gliosis and many areas of necrosis. Ultra-structural damage of moderate or low levels was observed in the fishes at C1 and C3 after 5 days and C1 after 25 days of treatment. In the skeletal muscle at 25 days of C3 treatment, different degrees of swelling and high necrosis were observed. This indicates that a defense mechanism was started with the accumulation of metal Cd in the tissues over time. Thus, the information provided in this study may be very useful for the deep understanding of the mechanisms of Cd stress in fish.

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“…They reviewed a wide range of literature, evaluating the data suitability in such a way that both exposure and whole-body metal levels should be measured by accepted analytical techniques and an exposure assessment based on standard BCF test methodologies. The rest of the BCF data come from individual articles [19][20][21][22][23][24][25][26][27][28]. If the literature did not contain calculated BCF values, these were estimated mainly by the fish-body concentration divided by exposure data.…”

Section: Construction Of Bcf Datasetsmentioning

confidence: 99%

Regression approaches to derive generic and fish group‐specific probability density functions of bioconcentration factors for metals

Tanaka

Ciffroy

Stenberg

et al. 2010

Enviro Toxic and Chemistry

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In the framework of environmental multimedia modeling studies dedicated to environmental and health risk assessments of chemicals, the bioconcentration factor (BCF) is a parameter commonly used, especially for fish. As for neutral lipophilic substances, it is assumed that BCF is independent of exposure levels of the substances. However, for metals some studies found the inverse relationship between BCF values and aquatic exposure concentrations for various aquatic species and metals, and also high variability in BCF data. To deal with the factors determining BCF for metals, we conducted regression analyses to evaluate the inverse relationships and introduce the concept of probability density function (PDF) for Cd, Cu, Zn, Pb, and As. In the present study, for building the regression model and derive the PDF of fish BCF, two statistical approaches are applied: ordinary regression analysis to estimate a regression model that does not consider the variation in data across different fish family groups; and hierarchical Bayesian regression analysis to estimate fish group-specific regression models. The results show that the BCF ranges and PDFs estimated for metals by both statistical approaches have less uncertainty than the variation of collected BCF data (the uncertainty is reduced by 9%-61%), and thus such PDFs proved to be useful to obtain accurate model predictions for environmental and health risk assessment concerning metals.

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Kinetics of cadmium accumulation and elimination in carp Cyprinus carpio tissues

Cited by 42 publications

References 40 publications

Haematological, blood biochemical and histopathological effects of sublethal cadmium and lead concentrations in common carp

Haematological, blood biochemical and histopathological effects of sublethal cadmium and lead concentrations in common carp

Cadmium Accumulation and Its Histological Effect on Brain and Skeletal Muscle of Zebrafish

Regression approaches to derive generic and fish group‐specific probability density functions of bioconcentration factors for metals

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