Kinetics of C-Reactive Protein Release in Different Forms of Acute Coronary Syndrome

Sánchez, Pedro L.; Rodríguez, María; Villacort, Eduardo; Albarrán, Carmen; Cruz, Ignacio; Moreiras, Javier Martín; Martı́n, Francisco; Pabón, Pedro; Martín-Luengo, Cándido

doi:10.1016/s1885-5857(06)60792-5

Cited by 22 publications

(18 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This suggests that it might be influenced by the degree of early myocardial tissue necrosis. Therefore, this variation in CRP kinetics should be taken into consideration when designing future studies 12 . …”

Section: Body Mass Index (Bmi) Systolic Blood Pressure (Sbp) Diastomentioning

confidence: 99%

Níveis de PCR são maiores em pacientes com síndrome coronariana aguda e supradesnivelamento do segmento ST do que em pacientes sem supradesnivelamento do segmento ST

Habib¹,

Kurdi²,

Aseri³

et al. 2011

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

show abstract

Section: Body Mass Index (Bmi) Systolic Blood Pressure (Sbp) Diastomentioning

confidence: 99%

Níveis de PCR são maiores em pacientes com síndrome coronariana aguda e supradesnivelamento do segmento ST do que em pacientes sem supradesnivelamento do segmento ST

Habib¹,

Kurdi²,

Aseri³

et al. 2011

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

show abstract

“…Earlier studies suggested that CRP levels in STEMI patients reached their peak values between 36 and 42 h after admission [10]. The degree of inflammation marked by CRP was associated with the degree of myocardial necrosis.…”

Section: Temporal Course Of Hs-crpmentioning

confidence: 90%

“…Furthermore, in this study they seem to correspond with the kinetics of NT-proBNP, which might still implicate a potential association between inflammation and HF. The ability to evaluate hs-CRP levels and to detect subtle differences over time in such a number of patients is of additional value to previous studies [10].…”

Section: Temporal Course Of Hs-crpmentioning

confidence: 99%

“…In the setting of an AMI elevated CRP levels on admission are associated with impaired myocardial reperfusion as depicted by lower Thrombolysis in Myocardial Infarction (TIMI) flow grades [6][7][8][9]. A clear difference in CRP patterns between different forms of acute coronary syndrome (ACS) was previously described in the early days after admission [10]. Currently, sparse data is available about time course of CRP levels and its association with reperfusion success after AMI.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

High-sensitivity C-reactive protein and long term reperfusion success of primary percutaneous intervention in ST-elevation myocardial infarction

Groot

Karper

Lipšic

et al. 2017

International Journal of Cardiology

View full text Add to dashboard Cite

show abstract

“…CRP is one of the most important acute-phase reactant, induced by tissue injury and mediated by hepatic production [30]. Previous studies could find a relation between hs-CRP measured at 48 h after infarction and IS [31], whereas admission levels of hs-CRP did not correlate with IS [10], probably due to the delayed CRP release [32]. In line with those previous data, no significant association between admission hs-CRP and IS was found in the present analysis.…”

Section: Predictive Value Of Biomarkersmentioning

confidence: 96%

Biomarker assessment for early infarct size estimation in ST-elevation myocardial infarction

Tiller

Reindl

Holzknecht

et al. 2019

European Journal of Internal Medicine

View full text Add to dashboard Cite

Background: High-sensitivity cardiac troponin T (hs-cTnT) represents the biomarker of choice for infarct size (IS) estimation in patients with acute ST-elevation myocardial infarction (STEMI). However, admission values of hs-cTnT are only weakly associated with IS. The aim of this study was to investigate the incremental value of different biomarkers measured on admission for IS estimation in STEMI patients. Methods: In this prospective observational study, we included 161 consecutive STEMI patients treated with primary percutaneous coronary intervention (pPCI). The following biomarkers were assessed on admission: hs-cTnT, N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) and neutrophil/lymphocyte ratio (NLR). IS was determined by cardiac magnetic resonance (CMR) imaging 3 (Interquartile range [IQR] 2 to 4) days after the index event. Results: Patients with large IS (> 19% of left ventricular myocardium) showed significantly higher levels of admission hs-cTnT (399.6 vs. 53.4 ng/L, p < .001), NT-pro-BNP (140 vs. 86 ng/L, p = .008) and NLR (6.4 vs. 4.1, p < .001). The combination of hs-cTnT, NT-pro-BNP and NLR on admission resulted in a significantly higher area under the curve (0.78; 95% CI 0.704 to 0.838, (p = .01)) for the prediction of large IS than admission hs-cTnT alone (0.69; 95% CI 0.619 to 0.767). Conclusions: In STEMI patients undergoing pPCI, a comprehensive biomarker approach on admission including hs-cTnT, NT-pro-BNP and NLR was significantly better for immediate infarct severity estimation as compared to hs-cTnT alone.

show abstract

Kinetics of C-Reactive Protein Release in Different Forms of Acute Coronary Syndrome

Cited by 22 publications

References 29 publications

Níveis de PCR são maiores em pacientes com síndrome coronariana aguda e supradesnivelamento do segmento ST do que em pacientes sem supradesnivelamento do segmento ST

Níveis de PCR são maiores em pacientes com síndrome coronariana aguda e supradesnivelamento do segmento ST do que em pacientes sem supradesnivelamento do segmento ST

High-sensitivity C-reactive protein and long term reperfusion success of primary percutaneous intervention in ST-elevation myocardial infarction

Biomarker assessment for early infarct size estimation in ST-elevation myocardial infarction

Contact Info

Product

Resources

About