Níveis de PCR são maiores em pacientes com síndrome coronariana aguda e supradesnivelamento do segmento ST do que em pacientes sem supradesnivelamento do segmento ST

Habib, Syed Shahid; Kurdi, Mohammad Ibrahim; Aseri, Zohair Al; Owais, Suriya M.

doi:10.1590/s0066-782x2010005000161

Cited by 27 publications

(17 citation statements)

References 23 publications

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“…Specific to our study design, serum levels of CRP, MMP-9 and MPO have shown significant elevations during the first 48 hours after a myocardial infarction. 49–52 In our study, serum and salivary levels of CRP demonstrated changes in concentrations in serum after the ablation procedure. Serum CRP levels rose significantly and progressively suggestive of the myocardial infarction 49 and ongoing inflammation that occurs post-ablation.…”

Section: Discussionsupporting

confidence: 56%

“…49–52 In our study, serum and salivary levels of CRP demonstrated changes in concentrations in serum after the ablation procedure. Serum CRP levels rose significantly and progressively suggestive of the myocardial infarction 49 and ongoing inflammation that occurs post-ablation. Salivary CRP levels also rose significantly post-ablation, however the increase in concentrations observed were less than those that occurred in serum.…”

Section: Discussionsupporting

confidence: 56%

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Salivary biomarkers associated with myocardial necrosis: results from an alcohol septal ablation model

Foley

Sneed

Steinhubl

et al. 2012

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Objective To determine if salivary biomarkers demonstrate utility for identifying aspects of myocardial necrosis. Methods Twenty-one patients undergoing alcohol septal ablation (ASA) for treatment of hypertrophic cardiomyopathy provided serum and unstimulated whole saliva at baseline and incremental time points post-ASA. Samples were analyzed for seven biomarkers related to myocardial damage, inflammation and tissue remodeling using immunosorbent assays. Levels were compared to baseline and levels observed in 97 healthy controls. Results Biomarkers of myocardial damage and inflammation (i.e., troponin I, creatine kinase-MB, myoglobin, C-reactive protein) rose in serum 2 to 812-fold after ASA (p<0.01). Significant elevations of 2 to 3.5-fold were observed with C-reactive protein and troponin I in saliva (p<0.02). Significant correlations between levels in serum and saliva were observed for C-reactive protein, matrix metalloproteinase-9, and myeloperoxidase (p < 0.001). Conclusions Select salivary biomarkers reflect changes that occur during, and subsequent to, myocardial necrosis caused by ASA.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionsupporting

confidence: 56%

Salivary biomarkers associated with myocardial necrosis: results from an alcohol septal ablation model

Foley

Sneed

Steinhubl

et al. 2012

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…Other studies found no difference in these and other platelet markers (e.g. mean platelet volume, platelet count) [38,39]. However, of the biochemical and physiological mechanisms associated with ambient PM exposure, only thrombus formation and vasoconstriction occur on such a rapid time scale.…”

Section: Discussionmentioning

confidence: 87%

Ambient fine particulate air pollution triggers ST-elevation myocardial infarction, but not non-ST elevation myocardial infarction: a case-crossover study

et al. 2014

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BackgroundWe and others have shown that increases in particulate air pollutant (PM) concentrations in the previous hours and days have been associated with increased risks of myocardial infarction, but little is known about the relationships between air pollution and specific subsets of myocardial infarction, such as ST-elevation myocardial infarction (STEMI) and non ST-elevation myocardial infarction (NSTEMI).MethodsUsing data from acute coronary syndrome patients with STEMI (n = 338) and NSTEMI (n = 339) and case-crossover methods, we estimated the risk of STEMI and NSTEMI associated with increased ambient fine particle (<2.5 um) concentrations, ultrafine particle (10-100 nm) number concentrations, and accumulation mode particle (100-500 nm) number concentrations in the previous few hours and days.ResultsWe found a significant 18% increase in the risk of STEMI associated with each 7.1 μg/m3 increase in PM2.5 concentration in the previous hour prior to acute coronary syndrome onset, with smaller, non-significantly increased risks associated with increased fine particle concentrations in the previous 3, 12, and 24 hours. We found no pattern with NSTEMI. Estimates of the risk of STEMI associated with interquartile range increases in ultrafine particle and accumulation mode particle number concentrations in the previous 1 to 96 hours were all greater than 1.0, but not statistically significant. Patients with pre-existing hypertension had a significantly greater risk of STEMI associated with increased fine particle concentration in the previous hour than patients without hypertension.ConclusionsIncreased fine particle concentrations in the hour prior to acute coronary syndrome onset were associated with an increased risk of STEMI, but not NSTEMI. Patients with pre-existing hypertension and other cardiovascular disease appeared particularly susceptible. Further investigation into mechanisms by which PM can preferentially trigger STEMI over NSTEMI within this rapid time scale is needed.

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“…Therefore, the observed variation in CRP concentrations among the types of ACS might be at least partially attributed to the differences in the area of the infarcted myocardium. On the other hand, there are also reports demonstrating lack of significant differences in CRP concentrations at baseline among patients with ACS [24, 25]. It should be also acknowledged that elevated CRP concentration on admission is suggested to be a marker for anatomic complexity of culprit lesions [23, 24].…”

Section: Discussionmentioning

confidence: 99%

Value of C-Reactive Protein as a Risk Factor for Acute Coronary Syndrome: A Comparison with Apolipoprotein Concentrations and Lipid Profile

Krintus

Koziński

Stefańska

et al. 2012

Mediators of Inflammation

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Objective. To investigate whether assessment of C-reactive protein (CRP) and apolipoproteins, besides the traditional lipid profile, enhances the assessment process for the risk of acute coronary syndrome (ACS). Methods. The study group consisted of 220 consecutive patients admitted to hospital within the first 6 hours from the onset of chest pain. Patients were diagnosed with unstable angina (n = 96), non-ST-elevation myocardial infarction (NSTEMI; n = 57), or ST-elevation myocardial infarction (STEMI; n = 67). ACS patients were compared with 116 healthy volunteers in a case-control study. The serum was assayed on admission for CRP, apolipoproteins ApoAI and ApoB100, and lipid parameters. Results. The highest concentrations of CRP were found in NSTEMI and STEMI, with a median value four-fold higher in ACS patients than in controls (P < 0.0001). Only CRP significantly increased the probability of ACS development (adjusted odds ratio for a 1 mg/L increase 1.90; 95% confidence interval [CI] 1.34–2.89) and explained 90% of the variation for ACS development. Similarly, we demonstrated the highest diagnostic accuracy for CRP among all investigated markers (area under the curve 0.80; 95% CI 0.75–0.85). Conclusions. Our study indicates that CRP superiorly to apolipoproteins and lipid profile facilitates the risk stratification for ACS occurrence.

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Níveis de PCR são maiores em pacientes com síndrome coronariana aguda e supradesnivelamento do segmento ST do que em pacientes sem supradesnivelamento do segmento ST

Abstract: Background: There is intense interest in the use of high-sensitivity C-reactive protein (hsCRP) for risk assessment. Elevated hsCRP concentrations early in acute coronary syndrome (ACS), prior to the tissue necrosis, may be a surrogate marker for cardiovascular co-morbidities.

Cited by 27 publications

References 23 publications

Salivary biomarkers associated with myocardial necrosis: results from an alcohol septal ablation model

Salivary biomarkers associated with myocardial necrosis: results from an alcohol septal ablation model

Ambient fine particulate air pollution triggers ST-elevation myocardial infarction, but not non-ST elevation myocardial infarction: a case-crossover study

Value of C-Reactive Protein as a Risk Factor for Acute Coronary Syndrome: A Comparison with Apolipoprotein Concentrations and Lipid Profile

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