Kinetics and molecular docking of vasicine from Adhatoda vasica : An acetylcholinesterase inhibitor for Alzheimer's disease

Ali, Sherin K.; Hamed, Ahmed R.; Soltan, Maha M.; El-Halawany, Ali M.; Hegazy, Usama M.; Hussein, Ahmed A.

doi:10.1016/j.sajb.2015.09.021

Cited by 25 publications

(14 citation statements)

References 19 publications

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“…The anti-thrombolytic activity is evaluated by withdrawing blood from the volunteers and allowed them to clot, and then the procedure was taken ahead by the modi ied Daginawala method (Uddin et al, 2013). Ali et al (2016), prepared methanol leaf extract by maceration and was puri ied with the HPLC method. This puri ied constituent was selected for docking studies and compared with tacrine acetylcholinesterase (Ali et al, 2016).…”

Section: Anti-tubercular Activitymentioning

confidence: 99%

“…Ali et al (2016), prepared methanol leaf extract by maceration and was puri ied with the HPLC method. This puri ied constituent was selected for docking studies and compared with tacrine acetylcholinesterase (Ali et al, 2016). Prasad et al (2011), prepared the n-hexane, methanol and water extracts of the Adhatoda vasica leaves and tested for the antibacterial and antifungal activities of the extracts in the fungal and bacterial strains.…”

Section: Anti-tubercular Activitymentioning

confidence: 99%

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An Updated Review: Adhatoda vasica

Fathima¹,

Joghee²,

Alex³

2020

ijrps

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The present review mainly focuses on the morphological and pharmacological activities of the Adhatoda vasica belonging to the family Acanthaceae, which is commonly referred to as Adosa or Adsogi. It also focuses on the evidence based therapeutic uses of A.vasica in various experimental models. This plant is found in all the ecosystem in India and other parts of the world as well. Because of its greater availability and multitude of pharmacological activities, the plant is being used in the treatment of numerous diseases. Extracts of various parts of the plants such as bark, root, leaf, flower, fruit and many a times, the whole plants are used in the management of pain, inflammation, asthma, cold, cough, diabetes, bronchitis, diarrhea, dysentery and other upper respiratory diseases and it is also used to heal wounds; is utilised as an insecticide, and also used as abortifacient. In asthma and acute stages of bronchitis, the extract of vasica offers an unflagging result by decreasing the thickness of the sputum. Because of the above mentioned reasons the plant has greater importance in the various systems of medicines such as Ayurveda, Siddha, and Unani. According to the texts, the plant has greater power on asthma, abortifacient and uterotonic. Numerous trials have been conducted to prove the effects of A.vasica on asthma which led to its inclusion in WHO manual. According to the present day studies the alkaloids such as vasicinone, vasicine, and oxyvasicine which are present in A.vasica are responsible for most of the activities. But extensive studies need to be conducted to understand the constituent responsible for abortifacient and uterotonic activity.

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Section: Anti-tubercular Activitymentioning

confidence: 99%

Section: Anti-tubercular Activitymentioning

confidence: 99%

An Updated Review: Adhatoda vasica

Fathima¹,

Joghee²,

Alex³

2020

ijrps

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“…Vasicine (VAS), an alkaloid belonging to the chemical class of pyrrolo 2,1-b quinazoline is isolated from Adhatoda vasica Nees (Acanthaceae) 17. It possesses diverse biological properties such as, acetylcholine esterase inhibition,18,19 anti-inflammatory and anti-microbial,20 anti-oxidant21,22 and abortifacient effects 23,24. Various studies reported the protective effect of antioxidant compounds against MI 25–27.…”

Section: Introductionmentioning

confidence: 99%

<p>Protective Effect Of Vasicine Against Myocardial Infarction In Rats Via Modulation Of Oxidative Stress, Inflammation, And The PI3K/Akt Pathway</p>

Jiang¹,

Zhang²,

Ding³

et al. 2019

DDDT

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BackgroundMyocardial infarction is the leading cause of damage to the heart and is classified as a major cause of death related to cardiovascular disease. In the present study, we intended to investigate the protective effect of vasicine (VAS) against myocardial infarction in rats, and its mechanism.MethodsMyocardial infarction was induced by isoproterenol (ISO, 100 mg/kg) at an interval of 24 h for 2 days. Different doses of VAS (2.5, 5, and 10 mg/kg body weight) were administered to the rats. The effect of VAS on oxidative stress markers such as, myocardial necrosis, myocardial ability and infarct volume, inflammatory cytokines, membrane-bound myocardial enzymes, and histopathological changes was investigated. Western blot analysis was also conducted to analyze the effect of VAS on autophagy (PI3K/Akt) and apoptosis (Bcl-2, Bax, and caspase-3). The number of apoptotic cells in the different groups was also identified using TUNEL.ResultsResults suggested that VAS causes reduction in myocardial necrosis by reduction of elevated LDH, CK-MB, and TnT levels. It also causes augmentation of left ventricular systolic pressure (LVSP) and myocardial contractility as determined in terms of +dp/dtmax and –dp/dtmax. Furthermore, VAS causes reduction of TNF-α and IL-6 levels. VAS also improved cardiac function via enhancing posterior wall thickness of the LV with concurrent increase in the mass of LV. In the present study, VAS caused activation of phosphorylated PI3K (p-PI3K) and phosphorylated Akt (p-Akt) in a dose-dependent manner. Furthermore, VAS suppressed apoptosis when tested on animals suffering from ISO-induced MI, by decreasing the expression of cleaved Caspase-3 and Bax while increasing the expression of Bcl-2.ConclusionIn conclusion, vasicine has a protective effect against MI in vivo, through inhibiting oxidative stress, inflammation and excessive autophagy, to suppress apoptosis via activation of the PI3K/Akt/mTOR signaling pathway.

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“…Plants provide complicated, mixed, and distinct nonnutrient elements which act as the main basis of drug discovery [ 1 ]. Plant extracts contain phytochemical constituents for miscellaneous medicinal activities which are bioactive in nature [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Antinociceptive and Antidiarrheal Activities of Hydromethanol and Petroleum Benzene Extract ofMicrocos paniculataBarks

Moushome

Akter

Aziz

2016

BioMed Research International

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Introduction. Microcos paniculata is traditionally used for treating diarrhea, wounds, cold, fever, hepatitis, dyspepsia, and heat stroke. Objective. To investigate the qualitative phytochemical constituents of hydromethanol (HMPB) and petroleum benzene extract of Microcos paniculata barks (PBMPB) and to evaluate their antinociceptive and antidiarrheal activities. Methods. Phytochemical constituents and antinociceptive and antidiarrheal activities were determined and evaluated by different tests such as Molisch's, Fehling's, Mayer's, Wagner's, Dragendorff's, frothing, FeCl3, alkali, Pew's, and Salkowski's test, general test of glycosides, Baljet and NH4OH test, formalin-induced paw licking, acetic acid-induced writhing, tail immersion, and hot plate tests, and castor oil and MgSO4 induced diarrheal tests. Results. These extracts revealed the presence of saponins, flavonoids, and triterpenoids and significantly (⁎ P < 0.05, versus control) reduced paw licking and abdominal writhing of mice. At 30 min after their administration, PBMPB revealed significant increase in latency (⁎ P < 0.05, versus control) in tail immersion test. In hot plate test, HMPB and PBMPB 200 mg/kg showed significant increase in response latency (⁎ P < 0.05, versus control) at 30 min after their administration. Moreover, both extracts significantly (⁎ P < 0.05, versus control) inhibited percentage of diarrhea in antidiarrheal models. Conclusion. Study results indicate that M. paniculata may provide a source of plant compounds with antinociceptive and antidiarrheal activities.

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Kinetics and molecular docking of vasicine from Adhatoda vasica : An acetylcholinesterase inhibitor for Alzheimer's disease

Cited by 25 publications

References 19 publications

An Updated Review: Adhatoda vasica

An Updated Review: Adhatoda vasica

<p>Protective Effect Of Vasicine Against Myocardial Infarction In Rats Via Modulation Of Oxidative Stress, Inflammation, And The PI3K/Akt Pathway</p>

Phytochemical Screening and Antinociceptive and Antidiarrheal Activities of Hydromethanol and Petroleum Benzene Extract ofMicrocos paniculataBarks

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