Kinetics and Mechanism of Non-Isothermal Decomposition of Some Cross-Linked Metal-Alginate Complexes Especially Trivalent Metal -Alginate Complexes

Tirkistani, Fahd A.; Hassan, Refat M.

doi:10.13005/ojc/280235

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…7, No. 2;2015 of electrical conductivity by the temperature increment, at early stage was recognized to the development of coordinated molecules of water in the amorphous phase by dehydration processes or formation of free-radical substrates in the studied complex (Tirkistani& Hassan, 2012).…”

Section: Resultsmentioning

confidence: 91%

Electrical Conductivity and Chemical Equilibria of Coordination Biopolymeric Cerium (IV)-Alginate Complex with Correlation between the Structure and Complex Stability

Zaafarany¹,

Altass²,

Al‐Fahemi³

et al. 2015

IJC

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In this research study, the cross-linked cerium (IV)-alginate complex, as coordination biopolymeric compound in the granules form, was prepared. It has been indicated from the x-ray diffraction patterns that the nature of alginate complex is amorphous. Additionally, it has been revealed from the infrared absorption spectra that cerium (IV) chelates the alginate macromolecular chains in the complex. The study has displayed that the range of  s OCO-is 1424 cm -1 and the range of  a s OCO-is 1605 cm -1. This indicates that a complexation type between the cation Ce 4+ and both carboxylate and hydroxyl functional groups of alginate macromolecule is usually takes place. The study has also measured the electrical conductivity () of coordination biopolymeric cerium (IV)-alginate complex, as function of temperature. It has been indicated from the measured value of the electrical conductivity, i.e., 1.04 x10-9 Siemens at 20 o C that the conductance of the complex lies in the range of semiconductors. The research has profoundly discussed with evaluation of the thermodynamic parameters. Afterwards, appropriate conduction mechanism based on the electrical conductivity and chemical equilibrium has also been suggested and discussed in terms of the complex stability in correlation with its coordination geometry.

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Section: Resultsmentioning

confidence: 91%

Electrical Conductivity and Chemical Equilibria of Coordination Biopolymeric Cerium (IV)-Alginate Complex with Correlation between the Structure and Complex Stability

Zaafarany¹,

Altass²,

Al‐Fahemi³

et al. 2015

IJC

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“…Using entropy as a guiding tool for drug development has been recently come into focus [63]. The entropy could be calculated based on the following equation Equation (10) [64]:…”

Section: Kinetics Of the Ambroxol Hydrochloride Pure And In The Mixturementioning

confidence: 99%

Thermo-Analytical and Compatibility Study with Mechanistic Explanation of Degradation Kinetics of Ambroxol Hydrochloride Tablets under Non-Isothermal Conditions

et al. 2021

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Ambroxol hydrochloride (AMB), used as a broncho secretolytic and an expectorant drug, is a semi-synthetic derivative of vasicine obtained from the Indian shrub Adhatoda vasica. It is a metabolic product of bromhexine. The paper provides comprehensive and detailed research on ambroxol hydrochloride, gives information on thermal stability, the mechanism of AMB degradation, and data of practical interest for optimization of formulation that contains AMB as an active compound. Investigation on pure AMB and in commercial formulation Flavamed® tablet (FT), which contains AMB as an active compound, was performed systematically using thermal and spectroscopic methods, along with a sophisticated and practical statistical approach. AMB proved to be a heat-stable and humidity-sensitive drug. For its successful formulation, special attention should be addressed to excipients since it was found that polyvinyl pyrrolidone and Mg stearate affect the thermal stability of AMB. At the same time, lactose monohydrate contributes to faster degradation of AMB and change in decomposition mechanism. It was found that the n-th order kinetic model mechanistically best describes the decomposition process of pure AMB and in Flavamed® tablets.

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“…On the other hand, the kinetics of non-isothermal decomposition of some coordination biopolymer trivalent-metal alginate cross-linked complexes such as Al (III), Cr (III), Fe (III), Ce (III) and La (III) has been investigated using a Mettler TA 3000 thermal analyzer in static air and were reported elsewhere [32,33]. The TG curves showed three stages of weight-loss, whereas the DTG curves indicated the presence of a series of thermal peaks associated with the TG curves.…”

Section: (As(oh) (Co 3 )mentioning

confidence: 99%

Temperature-Dependence of Electrical Conductivity for Some Natural Coordination Polymeric Biomaterials Especially Some Cross-Linked Trivalent Metal-Alginate Complexes with Correlation between the Coordination Geometry and Complex Stability

Zaafarany¹

2015

J Adv Chem Eng

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The electrical conductivity (ơ) of cross-linked arsenic (III) -alginate complex as a coordination polymeric biomaterial in the form of circular discs have been measured as a function of temperature. The measured values of the electrical conductivity were found to be in the range of semiconductors. The change of electrical conductivity as a function of temperature was found to be of considerable complexity (Arrhenius plot of ln ơ vs. 1/T ). The appearance of a parabola zone at the early stages was explained by the release of waters of crystalline, whereas the sharp increase in ơ values observed at the elevated temperatures was interpreted by the degradation process of the complex to give rise to the metal oxide as final product. The X-ray diffraction patterns indicated that the metalalginate complex is amorphous in nature. Infrared absorption spectra revealed a sort of complexation between the trivalent metal cations and the functional carboxylate and hydroxyl groups of alginate macromolecule. A suitable conduction mechanism in terms of the complex stability in relation to the coordination geometry is suggested and discussed. Journal of Advanced Chemical Engineering

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Kinetics and Mechanism of Non-Isothermal Decomposition of Some Cross-Linked Metal-Alginate Complexes Especially Trivalent Metal -Alginate Complexes

Cited by 5 publications

References 2 publications

Electrical Conductivity and Chemical Equilibria of Coordination Biopolymeric Cerium (IV)-Alginate Complex with Correlation between the Structure and Complex Stability

Electrical Conductivity and Chemical Equilibria of Coordination Biopolymeric Cerium (IV)-Alginate Complex with Correlation between the Structure and Complex Stability

Thermo-Analytical and Compatibility Study with Mechanistic Explanation of Degradation Kinetics of Ambroxol Hydrochloride Tablets under Non-Isothermal Conditions

Temperature-Dependence of Electrical Conductivity for Some Natural Coordination Polymeric Biomaterials Especially Some Cross-Linked Trivalent Metal-Alginate Complexes with Correlation between the Coordination Geometry and Complex Stability

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