Kinetics and mechanism of interaction of hexaaquachromium(III) with l-Dopa in aqueous medium: comparative antiparkinsonian studies

Baral, D K; Rout, Sudhanshu Sekhar; Behera, J. N.; Chandra, Sudam; Mohanty, P.

doi:10.1007/s11243-011-9460-8

Cited by 8 publications

(6 citation statements)

References 20 publications

(14 reference statements)

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“…19 Additionally, Holten-Andersen et al and Baral et al have proposed that ferric and chromium (III) complexes of L-Dopa could form through the coordination of amino/carboxyl groups and phenolic hydroxyls, respectively. 17,20 It seems that L-Dopa could interact via phenolic hydroxyls or/and amino/carboxyl groups competitively. In order to explain the mechanism of adsorption of L-Dopa and subsequent conjunction with collagen and antigen on the Si 3 N 4 substrate at atomic level, classical molecular dynamics simulation was conducted to investigate the adsorption pattern of L-Dopa.…”

Section: Molecular Models and Molecular Dynamics Simulationsmentioning

confidence: 99%

Unlabeled multi tumor marker detection system based on bioinitiated light addressable potentiometric sensor

Jia

Gao

et al. 2012

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Multi biomarkers' assays are of great significance in clinical diagnosis. A label-free multi tumor markers' parallel detection system was proposed based on a light addressable potentiometric sensor (LAPS). Arrayed LAPS chips with basic structure of Si(3)N(4)-SiO(2)-Si were prepared on silicon wafers, and the label-free parallel detection system for this component was developed with user friendly controlling interfaces. Then the l-3,4-dihydroxyphenyl-alanine (L-Dopa) hydrochloric solution was used to initiate the surface of LAPS. The L-Dopa immobilization state was investigated by the theoretical calculation. L-Dopa initiated LAPS' chip was biofunctionalized respectively by the antigens and antibodies of four tumor markers, α-fetoprotein (AFP), carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9) and Ferritin. Then unlabeled antibodies and antigens of these four biomarkers were detected by the proposed detection systems. Furthermore physical and measuring principles in this system were described, and qualitative understanding for experimental data were given. The measured response ranges were compared with their clinical cutoff values, and sensitivities were calculated by OriginLab. The results indicate that this bioinitiated LAPS based label-free detection system may offer a new choice for the realization of unlabeled multi tumor markers' clinical assay.

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Section: Molecular Models and Molecular Dynamics Simulationsmentioning

confidence: 99%

Unlabeled multi tumor marker detection system based on bioinitiated light addressable potentiometric sensor

Jia

Gao

et al. 2012

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“…But a Lineweaver and Burk plot of 1/ k obs versus 1/[CH 2 =CHX] at each temperature produced a straight line ( R 2 ≈ 0.99) with a positive slope and positive intercept (Fig. ), indicating the existence of a Michaelis–Menten type of intermediate complex between iridium(IV) and CH 2 =HX in a fast preequilibrium step .…”

Section: Resultsmentioning

confidence: 98%

Mechanistic Investigation of the Oxidative Cleavage of the Carbon–Carbon Double Bond in α,β‐Unsaturated Compounds by Hexachloroiridate(IV) in Acetate Buffer

Pal¹

2013

Int J of Chemical Kinetics

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The hexachloroiridate(IV) oxidation of α,β‐unsaturated compounds such as acrylic acid, acrylamide, and acrylonitrile (CH2=CHX; X = –COOH, –CONH2, and –CN) was carried out in NaOAc‐AcOH buffer medium. The reaction follows complex kinetics, being first order in [IrIV] and complex order in [CH2=CHX]. H+ ion has no effect on the reaction rate in the pH range 3.42–4.63. The pseudo–first‐order rate constant decreases with a decrease in the dielectric constant and with a decrease of ionic strength of the medium. The oxidation rate follows the sequence: acrylonitrile > acrylamide > acrylic acid. A mechanism is proposed involving the formation of an unstable intermediate complex between the substrate and the oxidant which is transformed to the radical cation in a slow rate‐determining step with the concomitant reduction of Ir(IV) to Ir(III). The radical cation subsequently decomposes to the aldehyde that appears as the ultimate product of the carbon–carbon double bond cleavage. The major product of oxidation was identified as HCHO by 1H NMR. Activation parameters for the slow rate‐determining step and thermodynamic parameters associated with the equilibrium step of the proposed mechanism have been evaluated. The enthalpy of activation is linearly related to the entropy of activation, and this linear relationship confirms that the oxidation of all the α,β‐unsaturated compounds follows a common mechanism.

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“…We have made the detailed studies of the complex forming properties of L-dopa with Cr(III) and subsequently, the bonding conditions relating to the complexes formed and stability of the complex was also reported [9].…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Characterization and Antioxidant Activity of Potassium Cis-Diaqua-Bis (Oxalato) Chromate (Iii) With Levodopa and Carbidopa

Rout

Pattanaik

Chandra

et al. 2018

Int J Pharm Pharm Sci

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Objective: These studies focus on the interaction between two clinically active antiparkinsonian drugs L-dopa (L) and carbidopa (C) with the cis-[Cr(C2O4)2(H2O)2] - Methods:The resulting synthesized complexes were characterized by UV-VIS and FTIR spectroscopy. Evaluation of antioxidant activities of this cis-[Cr(C and evaluation of the synthesized product from a coordination chemistry aspect with respect to the possibility of its antioxidant activity and its therapeutic application in the treatment of Parkinson disease. Results:The results of spectral analysis of the synthesized products indicate that complexes have a Cr(III) ion coordinated via the carboxylic and amino group. In the reduction of radical DPPH -carbidopa(MC) and standard butylated hydroxytoluene (BHT) were carried out by using 1,1-diphenyl-1-picrylhydrazyl free radical (DPPH), 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cations and hydrogen peroxide method.· and the formation of radical monocation ABTS ·+ the ability to scavenge radical was measured in these experiments by the discoloration of the solution. However, in hydrogen peroxide method, the increased in absorbance showing its scavenging potential. The scavenging capacity of the test compounds and standard on the DPPH, ABTS ·+ , H2O2 decreased in the order BHT>ML>MC>C>L which were 98.4, 96.4, 86.4, 68.3, 49.7% for DPPH, BHT>ML>L>MC>C which were 99.3, 96.9, 96.3,66.6, 53.4% for ABTS ·+ , BHT>ML>MC>L>C which were 68.8%, 52.4%, 49.6%, 43.1% and 37.7% for H2O2 Conclusion:The experimental findings showed that cis-[Cr(C at the concentration of 50 µg/ml, respectively.

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Kinetics and mechanism of interaction of hexaaquachromium(III) with l-Dopa in aqueous medium: comparative antiparkinsonian studies

Cited by 8 publications

References 20 publications

Unlabeled multi tumor marker detection system based on bioinitiated light addressable potentiometric sensor

Unlabeled multi tumor marker detection system based on bioinitiated light addressable potentiometric sensor

Mechanistic Investigation of the Oxidative Cleavage of the Carbon–Carbon Double Bond in α,β‐Unsaturated Compounds by Hexachloroiridate(IV) in Acetate Buffer

Synthesis, Characterization and Antioxidant Activity of Potassium Cis-Diaqua-Bis (Oxalato) Chromate (Iii) With Levodopa and Carbidopa

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