Kinetics and Mechanism of Bacterial Disinfection by Chlorine Dioxide

Abstract

Survival data are presented for a fecal strain of Escherichia coli exposed to three concentrations of chlorine dioxide at four temperatures. Chick's first-order reaction equation is generalized to a pseudo n th-order model. Nonlinear least squares curve-fitting of the survival data to the n th order model was performed on an analogue computer. The data were observed to follow fractional order kinetics with respect to survival concentration, with an apparent activation energy of 12,000 cal/mole. Initial experiments support the thesis that the mechanism of chlorine dioxide kill occurs via disruption of protein synthesis.

The effects of biocides on the growth of aerophytic green algae (Chlorella sp.) isolated from a cave environment

“…Depending on the chlorine dioxide concentration and the length of exposure, a 7-30% reduction of microorganisms can occur within 1 h [58]. It was found [59] that a 0.25 mg/L solution of chlorine dioxide inactivated a strain of E. coli in less than 60 s at pH 6.5. The same concentration, under the same conditions, inactivated a strain of E. coli in 25 s at pH 8.5 [58].…”

Combination of aerosolized acetic acid and chlorine dioxide‐releasing film to inactivate Salmonella enterica and its effect on quality of tomatoes and Romaine lettuce

“…The inactivation of microorganisms by ClO 2 is due to a disruption of protein synthesis (Benarde, Snow, Olivieri, & Davidson, 1967) and loss of permeability control with nonspecific oxidative damage to the outer membrane, leading to the destruction of the trans-membrane ionic gradient (Berg, Roberts, & Matin, 1986). ClO 2 as a strong oxidizing agent also reacts with plant cells and can result in cellular leakage and tissue damage.…”

Can chlorine dioxide prevent the spreading of coronavirus or other viral infections? Medical hypotheses

“…Regarding the wet atmosphere we can assume that the viruses are also wet, or even that they can be found in small water droplets containing 0.025 ppm (m/m) ClO 2 . We have no direct data for the inactivating time of viruses in such a solution, but we have an estimated 15 ± 5 s killing time value for an E. coli bacterium in a 0.25 ppm (m/m) ClO 2 solution [2]. It is reasonable to assume that the killing time would be 10 times longer in a 10 times more dilute solution, i.e., 150 s 5 2.5 min.…”