Kinetically controlled synthesis of monoglyceryl esters from chiral and prochiral acids methyl esters catalyzed by immobilized Rhizomucor miehei lipase

Kinetics and mechanism of regioselective monoacetylation of 3-aryloxy-1,2-propandiols using immobilized Candida antarctica lipase

“…Higher yield of enantioselective product is obtained in final 37 step when pure monoacetylated product is used as substrate. 38 Lipases are the most important group of biocatalysts in non-39 aqueous enzymology; they do not need cofactors for assisting the 40 reaction, are capable of differentiating the chiral centers and have 41 extensive substrate specificity [23][24][25][26][27][28][29][30][31][32]. Lipases are widely 42 present in different sources which include bacteria and fungi 43 and hence can be readily available for biotransformation of 44 interest.…”

Diesterification of 3‐[(β‐Cyclodextrinyl)succinamido]propane‐1,2‐diol Catalysed by Lipase: Diastereoselectivity or Tridimensional Substrate Specificity?

“…The two diastereoisomeric leucine derivatives 16 and 17 were subjected to lipase‐catalysed esterification under identical experimental conditions and quantification showed similar conversions (55–60 % conversion; Scheme ). This last experiment clearly demonstrated that lipozyme ® is not diastereoselective for these transesterification reactions, contrary to the results obtained with monoacylglycerol 17. If diastereoselectivity is not responsible for the difference in the conversion of 3‐[(β‐cyclodextrinyl)succinamido]propane‐1,2‐diol, it can be hypothesized that the difference is due to the spatial configurations of the R and S substrates.…”

“…For example, PS lipase from Amano was reported to give a higher diastereoisomeric excess ( de ) than AK lipase (62 % < de < 96 %) 16. Finally, Mucor miehei lipase, which was used in this study, successfully catalysed the synthesis of monoacylglycerol with a diastereoisomeric excess superior to 99 % 17. As shown in this report, this diastereoselectivity depends on the enzyme and substrate.…”

Transesterification of Palm Oil for the Production of Biodiesel

“…The extra cellular and the intracellular lipases are also able to catalyze the transesterification of triglycerides effectively (Andreina et al, 2011;Giovana et al, 2011;Ríos et al, 2011;Junmin et al, 2011;Shiva and Patrick, 2011).…”