Kinetic tremor and cerebellar ataxia as initial manifestations of Kikuchi–Fujimoto's disease

Moon, Jusun; Kim, Gwang Il; Koo, Young-Ho; Kim, Hyun‐Sook; Kim, Wonchan; Kim, Ok-Su; Oh, Seung-Hun

doi:10.1016/j.jns.2008.10.021

Cited by 26 publications

(24 citation statements)

References 5 publications

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“…KFD has various extranodal manifestations, including skin lesions, gastrointestinal symptoms or splenomegaly [1]. Neurological complications, including aseptic meningitis, mononeuritis multiplex or acute cerebellar ataxia, are not common [2], and a meta-analysis of 244 KFD cases in 181 published case reports demonstrated 11% of incidence of neurological involvements [3]. The most common neurological complication is aseptic meningitis, which is observed in 2.8-9.8% of KFD cases [4,5].…”

Section: Introductionmentioning

confidence: 99%

Recurrent aseptic meningitis in association with Kikuchi-Fujimoto disease: case report and literature review

et al. 2012

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BackgroundKikuchi Fujimoto disease (KFD), or histiocytic necrotising lymphadenitis, is a benign and self-limiting condition characterised by primarily affecting the cervical lymph nodes. Recurrent aseptic meningitis in association with KFD is extremely rare and remains a diagnostic challenge.Case presentationWe report a 28-year-old man who presented 7 episodes of aseptic meningitis associated with KFD over the course of 7 years. Histopathological findings of enlarged lymph nodes led to the diagnosis of KFD. The patient’s headache and lymphadenopathy spontaneously resolved without any sequelae.ConclusionsA diagnosis of KFD should be considered when enlarged cervical lymph nodes are observed in patients with recurrent aseptic meningitis. A long-term prognosis remains uncertain, and careful follow-up is preferred.

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Section: Introductionmentioning

confidence: 99%

Recurrent aseptic meningitis in association with Kikuchi-Fujimoto disease: case report and literature review

et al. 2012

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“…The nodes are firm, smooth, mobile and about 1–2 cm in size and patients may often experience pain associated with nodal enlargement. Neurological symptoms such as ataxia, tremors and aseptic meningitis have also been described in some patients 6,7. Anemia, leukopenia, elevated immunoglobulin levels, and elevated erythrocyte sedimentation rate can be seen in the laboratory studies 1.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi's Disease: A Rare Cause of Fever and Lymphadenopathy

Vivekanandarajah

Krishnarasa

Hurford

et al. 2012

Clin Med�Insights�Pathol

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Kikuchi’s disease is a benign condition that occurs in women. A young woman presented to the hospital with fevers and cervical lymphadenopathy. Infectious work-up was negative except for streptococcus pharyngitis. Imaging studies revealed the presence of diffuse cervical and axillary lymphadenopathy. The fevers persisted and she underwent excisional cervical lymph node biopsy that revealed histiocytic necrotizing lymphadenitis corresponding to a benign diagnosis of Kikuchi’s disease. Three months later, the patient was afebrile and there was complete resolution of the cervical lymphadenopathy.

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“…Cerebellar ataxia, diplopia and slowing of ideation are commonly observed 8. In one case, epileptic manifestations have been associated with confusion 9…”

Section: Discussionmentioning

confidence: 99%

Encephalitis and CSF increased level of interferon- in Kikuchi-Fujimoto disease

et al. 2012

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Neurological manifestations have been reported in Kikuchi-Fujimoto disease (KFD). Characteristics of brain lesions are not defined. In addition, no biological indexes are known to help clinicians along the diagnosis process. The authors describe encephalitis associated with KFD. Brain MRI, positron emission tomography (PET) scan and a large biological assessment including interferon α (INF-α) level measurement in cerebrospinal fluid (CSF) were performed. A 39-year-old man with chronic headaches developed diplopia, slow ideation and behavioural disturbances. MRI showed brain lesions particularly in the pontine region and internal temporal lobes with enhancement of the perivacular space and the walls of the lateral ventricle. The IFN-α level was increased in the CSF without viral infection. Cervical and mediastinal adenitis were evident as a hypermetabolic focus on a PET scan, and biopsy confirmed the diagnosis of KFD. The encephalitis spontaneously remitted. The authors characterised brain lesions especially related to KFD in association with increased of IFN-α level in the CSF.

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Kinetic tremor and cerebellar ataxia as initial manifestations of Kikuchi–Fujimoto's disease

Cited by 26 publications

References 5 publications

Recurrent aseptic meningitis in association with Kikuchi-Fujimoto disease: case report and literature review

Recurrent aseptic meningitis in association with Kikuchi-Fujimoto disease: case report and literature review

Kikuchi's Disease: A Rare Cause of Fever and Lymphadenopathy

Encephalitis and CSF increased level of interferon- in Kikuchi-Fujimoto disease

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