Kinetic spectrophotometric method for the determination of morphine in biological samples

Kinetic Spectrophotometry Method for the Determination of Morphine, Nalbuphine and Naltrexone Drugs in Bulk and Pharmaceutical Formulations

“…Statistical analysis of the results obtained by both the proposed method and reported methods. 18,36,45 revealed no significant difference in the performance of the two methods regarding accuracy and precision as revealed by t-test and F-test, respectively (Table 6). …”

“…17 Nevertheless, little trials had been reported for using spectrophotometry for morphine detection. 18 Nalbuphine (NAB) (-)-17-(cyclobutylmethyl)-4,5a-epoxymorphinan-3,6a,14-triol (Fig. 1b) is a semisynthetic narcotic agonist-antagonist of the phenanthrene series.…”

Kinetic Spectrophotometric Determination of Morphine in Pharmaceutical Samples

“…These include: spectrophotometry 5,6 , immuno chromatography 7 , potentiometry 8,9 , simultaneous voltammetric and amperometric 10 , gc-mass 1,11,26 , cyclicvoltametry and amperometry 12 , cyclicvoltametry 13,14 , sequential injection analysis 4 ,chemiluminescence 15 , kinetic potentiometric 9 , high performance liquid chromatography [16][17][18][19] , gas chromatography 20 , capillary electrophoresis 21 , ion mobility spectrometry 22,23 . These methods are efficient, but require expensive instrument and are expensive and many of them have needing time to complete the determination.…”

Electrocatalytic determination of morphine at the surface of a carbon paste electrode spiked with a hydroquinone derivative and carbon nanotubes

“…However, MS is an expensive technique, and fluorescence always needs critical derivatization reactions. Spectrophotometric detection systems, which are simple and inexpensive methods, can improve sensitivity but suffer from a limited linear range and/or a high limit of detection [18,19]. Preconcentration by solid-phase extraction (SPE) is another procedure to improve sensitivity in the analyses of complex matrix samples such as biological fluids in order to reduce the influence of interferences.…”

“…Preconcentration by solid-phase extraction (SPE) is another procedure to improve sensitivity in the analyses of complex matrix samples such as biological fluids in order to reduce the influence of interferences. This procedure, that has disadvantages such as being time-consuming and need of organic solvents, was used in different reported studies for morphine determination [9,12,13,15,19]. Electrochemical analysis, which is safe, rapid, simple, and low-cost, has become of growing importance in medicine and biotechnology, environmental monitoring, and different applications in industrial process control.…”