Kinetic, metabolic and macromolecular response of bacteria to chronic nanoparticle exposure in continuous culture

Faghihzadeh, Fatemeh; Anaya, Nelson M.; Astudillo‐Castro, Carolina; Oyanedel-Craver, Vinka

doi:10.1039/c8en00325d

Cited by 25 publications

(34 citation statements)

References 48 publications

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“…Studies utilizing similar delayed exposure protocols have also yielded a decrease in the stationary phase when S. oneidensis MR-1 was exposed to chromium(VI) and E. coli to silver nanoparticles (AgNPs). 31,32 Previous work has shown that NMC toxicity to S. oneidensis MR-1 is related to its dissolution and release of ions, particularity nickel and cobalt, into the growth media. 12 Although some of these metals are micronutrients, metal homeostasis of the organism is disturbed at higher concentrations of nickel and copper, which could cause oxidative stress, the replacement of the native metal cofactor of some proteins, or the binding of metals with critical functional groups on proteins or nucleic acids.…”

Section: Resultsmentioning

confidence: 99%

Chronic exposure to complex metal oxide nanoparticles elicits rapid resistance in Shewanella oneidensis MR-1

et al. 2019

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Section: Resultsmentioning

confidence: 99%

Chronic exposure to complex metal oxide nanoparticles elicits rapid resistance in Shewanella oneidensis MR-1

et al. 2019

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“…Faghihzadeh et al showed that acute and chronic exposure to AgNPs causes genetic and phenotypic changes in E. coli, which ultimately leads to resistance [ 81 ]. One of the changes observed by the authors was a modification of composition and amount of EPS secreted by E. coli .…”

Section: Interactions Involved In Biofilm Resistance To the Nanopamentioning

confidence: 99%

“…One of the changes observed by the authors was a modification of composition and amount of EPS secreted by E. coli . Specifically, through up-regulation of capsular polysaccharide regulon gene ( cpsB gene), the amount of biofilm polysaccharides was increased after exposure to AgNPs [ 81 ]. Additionally, the ATP-dependent efflux of silver was also increased due to overexpression of copper transporter gene ( copA gene).…”

Section: Interactions Involved In Biofilm Resistance To the Nanopamentioning

confidence: 99%

Interactions of Gold and Silver Nanoparticles with Bacterial Biofilms: Molecular Interactions behind Inhibition and Resistance

Joshi

Singh

Mijaković

2020

IJMS

166

113

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Many bacteria have the capability to form a three-dimensional, strongly adherent network called ‘biofilm’. Biofilms provide adherence, resourcing nutrients and offer protection to bacterial cells. They are involved in pathogenesis, disease progression and resistance to almost all classical antibiotics. The need for new antimicrobial therapies has led to exploring applications of gold and silver nanoparticles against bacterial biofilms. These nanoparticles and their respective ions exert antimicrobial action by damaging the biofilm structure, biofilm components and hampering bacterial metabolism via various mechanisms. While exerting the antimicrobial activity, these nanoparticles approach the biofilm, penetrate it, migrate internally and interact with key components of biofilm such as polysaccharides, proteins, nucleic acids and lipids via electrostatic, hydrophobic, hydrogen-bonding, Van der Waals and ionic interactions. Few bacterial biofilms also show resistance to these nanoparticles through similar interactions. The nature of these interactions and overall antimicrobial effect depend on the physicochemical properties of biofilm and nanoparticles. Hence, study of these interactions and participating molecular players is of prime importance, with which one can modulate properties of nanoparticles to get maximal antibacterial effects against a wide spectrum of bacterial pathogens. This article provides a comprehensive review of research specifically directed to understand the molecular interactions of gold and silver nanoparticles with various bacterial biofilms.

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“…These ECS were able to modify the size and zeta potential of the nanoparticles by causing their agglomeration. In addition, the composition of the ECS depended on the growth conditions used [17]. On the other hand, the interaction of the nanoparticles in pathophysiological environments leads to the formation of biomolecule coronas (similar to the ECS) around the nanoparticles that prevent their contact with the pathogens and decrease their bactericidal activity [18].…”

Section: Defense Mechanisms Against Different Sizes Of Metal and Mmentioning

confidence: 99%

Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles

Niño-Martínez

Orozco

Martínez-Castañón

et al. 2019

IJMS

222

139

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The increase in bacterial resistance to one or several antibiotics has become a global health problem. Recently, nanomaterials have become a tool against multidrug-resistant bacteria. The metal and metal oxide nanoparticles are one of the most studied nanomaterials against multidrug-resistant bacteria. Several in vitro studies report that metal nanoparticles have antimicrobial properties against a broad spectrum of bacterial species. However, until recently, the bacterial resistance mechanisms to the bactericidal action of the nanoparticles had not been investigated. Some of the recently reported resistance mechanisms include electrostatic repulsion, ion efflux pumps, expression of extracellular matrices, and the adaptation of biofilms and mutations. The objective of this review is to summarize the recent findings regarding the mechanisms used by bacteria to counteract the antimicrobial effects of nanoparticles.

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Kinetic, metabolic and macromolecular response of bacteria to chronic nanoparticle exposure in continuous culture

Abstract: Effect of specific growth rates on metabolic and macromolecular response of bacteria to chronic antimicrobial nanoparticle exposure are studied.

Cited by 25 publications

References 48 publications

Chronic exposure to complex metal oxide nanoparticles elicits rapid resistance in Shewanella oneidensis MR-1

Chronic exposure to complex metal oxide nanoparticles elicits rapid resistance in Shewanella oneidensis MR-1

Interactions of Gold and Silver Nanoparticles with Bacterial Biofilms: Molecular Interactions behind Inhibition and Resistance

Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles

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