Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles

Niño-Martínez, Nereyda; Orozco, Marco Felipe Salas; Martínez-Castañón, Gabriel Alejandro; Méndez, Fernando Torres; Ruíz, Facundo

doi:10.3390/ijms20112808

Cited by 222 publications

(147 citation statements)

References 88 publications

Supporting

Mentioning

139

Contrasting

Order By: Relevance

“…It was difficult to discern the morphologies of individual cells in optical microscope images of Gram-stained cells. However, morphological changes were observed in the S. aureus cells, indicating that the AgNPs had higher potency against Gram-positive bacteria, in agreement with previous reports [52,53].…”

Section: Optical Microscopysupporting

confidence: 92%

Extracellular Synthesis and Characterization of Silver Nanoparticles—Antibacterial Activity against Multidrug-Resistant Bacterial Strains

et al. 2020

View full text Add to dashboard Cite

Herein, we report the use of a cell-free extract for the extracellular synthesis of silver nanoparticles (AgNPs) and their potential to address the growing threat of multidrug-resistant (MDR) pathogenic bacteria. The reproducibility of AgNP synthesis was good and AgNP formation kinetics were monitored as a function of various reaction factors via ultraviolet-visible absorption spectroscopy. This green method was dependent on the alkaline pH of the reaction mixture. With the addition of dilute sodium hydroxide, well-dispersed AgNPs could be produced in large quantities via the classical nucleation and growth route. The new biosynthetic route enabled the production of AgNPs within a narrow size range of 4 to 17 nm. The AgNPs were characterized using various techniques and their antibacterial activity against MDR pathogenic bacteria was evaluated. Field-emission scanning electron microscopic imaging revealed prominent morphological changes in Staphylococcus aureus cells due to mechanical damage, which led to cell death. Escherichia coli cells showed signs of contraction and intracellular fluid discharge as a consequence of disrupted cell membrane function. This new biologically-assisted extracellular strategy is potentially useful for the decontamination of surfaces and is expected to contribute to the development of new products containing AgNPs.

show abstract

Section: Optical Microscopysupporting

confidence: 92%

Extracellular Synthesis and Characterization of Silver Nanoparticles—Antibacterial Activity against Multidrug-Resistant Bacterial Strains

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Diverse effects of nanoparticles of different metal oxides with the same oxidation state, i.e. ZnO and CuO, on Staphylococcus aureus and Enterococcus hirae[80][81]. In addition, the toxicity of n-Cr 2O3 has been corroborated by the findings ofRamesh et al (2012) [82], who employed the disk diffusion test method to illustrate the antibacterial effects of Cr2O3 nanoparticles.…”

mentioning

confidence: 82%

“…Zjawisko to polega na zmianie naturalnego SFT VOL. 54 ISSUE 2, 2019, PP [70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87][88]. have been attributable to the very small sizes of molecules and their increased reactivity due to the large area of the n-TiO2 particle.…”

mentioning

confidence: 99%

Metal Nanoparticles in Surface Waters – a Risk to Aquatic Organisms

Tomczyk-Wydrych¹,

Rabajczyk

2019

SFT

View full text Add to dashboard Cite

Nanocząstki metali w wodach powierzchniowych -zagrożenie dla organizmów wodnychABSTRACT Purpose: The aim of this paper is to provide information on the risks posed by metal nanoparticles released into surface waters. Introduction: Currently, the use of nanoparticles of metal and metal oxides (NPMOs) is extremely popular in various industries, and in medicine and households. Nanoparticles and nanocompounds have become significant contributors to technological progress due to their physicochemical properties such as the melting point, electrical and thermal conductivity, catalytic activity, light absorption and scattering, as well as biocompatible and bactericidal properties. These functions cause their increased performance compared to their macro counterparts. However, it should be noted that the properties of nanocomponents can create new risks to the environment and consumers. Based on existing literature, a conclusion can be drawn that metal nanoparticles are a potential threat to plant and animal organisms, and humans. It is, therefore, necessary to intensify efforts to understand the mobility, reactivity and durability of nanocomponents in various environmental components, especially in the aquatic environment, and their toxicity to organisms. Methodology: This paper is a literature review. Conclusions:The increasing use of nanosubstances, in both commercial and industrial products, has caused an increasing concentration and diversity of these substances in aquatic ecosystems. Based on the analysis of literature reports, it can be concluded that the size of nanoparticles, their structure and arrangement, as well as surface properties, are subject to constant changes in the environment as a result of their interactions with other components, and of the balances shaped by a variety of geochemical and biological factors. Numerous studies conducted in recent years in the field of nanoecotoxicology have demonstrated the existence of a risk to aquatic organisms, which could lead to their impaired development and even death. Unfortunately, the lack of a standard technique for assessing the toxicity of nanoparticles in various biological systems, such as the reproductive, respiratory, nervous and gastrointestinal systems, and the developmental stages of aquatic organisms, makes it impossible to conduct such studies in a standardised fashion. Reports of the toxicity of metal and metal oxide nanoparticles in relation to various forms of living organisms warrant in-depth investigations into how these particles function in aqueous solutions and interact with standard substances. This is an open access article under the CC BY-SA 4.0 license (https://creativecommons.org/licenses/by-sa/4.0/). ABSTRAKTCel: Celem artykułu jest przedstawienie informacji na temat zagrożeń, jakie stanowią nanocząstki metali wprowadzane do wód powierzchniowych. Wprowadzenie: Obecnie wykorzystanie nanocząstek metali i tlenków metali (NPMOs) cieszy się ogromną popularnością w różnych gałęziach przemysłu, medycynie i gospodarstwach domowych. Nanocz...

show abstract

“…Metal/metal oxide NP have become widespread in medical antibacterial usage in recent years. They may inherently exhibit particularly toxic effects,37,38 that bacteria alas can develop resistance against 39–41. Meanwhile, progress in supramolecular chemistry for the design of biocompatible organic NP also for antibacterial treatment has displayed some successful results, especially with regard to cationic polymeric NP 42,43.…”

Section: Introductionmentioning

confidence: 99%

Evolving Technologies and Strategies for Combating Antibacterial Resistance in the Advent of the Postantibiotic Era

Karaman

Ercan

Bakay

et al. 2020

Adv Funct Materials

123

View full text Add to dashboard Cite

The threats posed by the impending "postantibiotic era" have put forward urgent challenges to be overcome by providing new diagnostic and therapeutic regimes for improved diagnosis and treatment of bacterial infections. Antibiotic resistance and incurable bacterial infections are especially important in a society faced with rapid demographic changes. With very few new antibiotics in the drug development pipeline, not being able to match the pace of antimicrobial resistance evolution, developments within other fields such as materials sciences and medical technologies are required to realize innovative antibacterial approaches. This progress report presents recent advances in especially nanotechnology-based approaches and their concomitant use with complementary antibacterial treatments. Synergistically improved antibacterial activity can be reached by considering novel, promising approaches such as photodynamic and photothermal therapy as well as cold atmospheric pressure treatments as complementary strategies to fight against antibacterial resistance. Moreover, this report describes how these novel technologies can be further improved especially by integration of nanomaterials into the currently applied single modal strategies against bacterial infections.

show abstract

Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles

Cited by 222 publications

References 88 publications

Extracellular Synthesis and Characterization of Silver Nanoparticles—Antibacterial Activity against Multidrug-Resistant Bacterial Strains

Extracellular Synthesis and Characterization of Silver Nanoparticles—Antibacterial Activity against Multidrug-Resistant Bacterial Strains

Metal Nanoparticles in Surface Waters – a Risk to Aquatic Organisms

Evolving Technologies and Strategies for Combating Antibacterial Resistance in the Advent of the Postantibiotic Era

Contact Info

Product

Resources

About