Kinetic examination of the mechanical transition of polymethyl methacrylate films prepared from aqueous dispersions

Dynamic mechanical thermal analysis of hypromellose 2910 free films

“…Although DMA is an essential approach in many scientific areas involving materials characterisation, it is still largely underused in the pharmaceutical field. Up to now, DMA has been used in the analysis of film viscoelasticity and temperature-induced transitions [13][14][15][16], in the characterisation of the mechanical properties of pellets [17,18] or in the measurement of glass transition temperatures of powdered materials [19,20].…”

Experimental investigation of the effect of particle cohesion on the flow dynamics in a spheronizer

“…Its value is known to decrease with an increase of the temperature until it reaches a stable value that depends on the polymer properties . For the PEA/PMMA copolymer, the elastic modulus stabilizes at 6 × 10 6 Pa around 35°C and remains around this value as the temperature is increased to 60°C . The contact area and contact time are also affected by the pressure applied on the polymer layer during a collision.…”

“…. The contact time was calculated while taking into account the change with temperature of the elastic modulus of the PEA/PMMA copolymer . Different values of the shear rate from 0.01 to 200 s −1 were used to calculate the mean normal collision velocity, which are representative of the values considered in Refs .…”