Dynamic mechanical thermal analysis of hypromellose 2910 free films

Cespi, Marco; Bonacucina, Giulia; Mencarelli, Giovanna; Casettari, Luca; Palmieri, G

doi:10.1016/j.ejpb.2011.05.008

Cited by 29 publications

(9 citation statements)

References 30 publications

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“…Flow curve of the Sepifilm dispersions is reported in Fig. 1, overlapped with the flow curves determined in a previous work for several grades of hypromellose 2910 water dispersion [9]. Surprisingly, the Sepifilm flow curve is perfectly superimposed with the flow curves of hypromellose 2910 6 cps (indicated as Methocel E6 Data for pure hypromellose are from Cespi et al [9].…”

Section: Rheological Analysis Of Water Dispersionssupporting

confidence: 71%

“…The obtained results show a negative correlation between the amount of Sepisperse and the film time-dependency, which can be attributed either to the reduction of the plasticizer or the increase of the pigments, or probably to both factors. However, even if the time-dependency variation between the different formulations were easily detected by DMA, it appears modest in absolute terms, at least in the frequency range analysed, and numerically comparable to the variation observed in free films of pure HPMC with different molecular weights [9].…”

Section: Characterization Of Polymeric Filmssupporting

confidence: 50%

“…Although a wide literature is available concerning hypromellose water dispersion behaviour [2][3][4][5][6][7][8] and films characterization [9][10][11][12][13][14], there is a complete lack of information concerning the "ready to use" products. Moreover, it is also difficult to extrapolate information from the current knowledge on hypromellose based systems, since the qualitative and quantitative composition of the formulated products is often unknown for patent reasons.…”

Section: Introductionmentioning

confidence: 99%

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Rheological and thermo-mechanical properties of Sepifilm–Sepisperse water dispersions and films

2013

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Section: Rheological Analysis Of Water Dispersionssupporting

confidence: 71%

Section: Characterization Of Polymeric Filmssupporting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

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Rheological and thermo-mechanical properties of Sepifilm–Sepisperse water dispersions and films

2013

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“…A further concern is that if the drug is formulated at a super-saturated concentration, relative to its solubility in the polymer, it is likely to phase separate by crystallising during storage. Crystallisation could potentially change the mechanical properties of the film, alter the dissolution rate, change the mouth feel and/or taste of the product and possibly alter the in-vivo fate of the drug (Cespi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Ink-jet printing versus solvent casting to prepare oral films: Effect on mechanical properties and physical stability

Buanz

Belaunde

Soutari

et al. 2015

International Journal of Pharmaceutics

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The aim of this work was to compare and contrast the mechanical properties and physical stabilities of oral films prepared with either thermal ink-jet printing (TIJP) or solvent casting (SC). Clonidine hydrochloride was selected as a model drug because of its low therapeutic dose and films were prepared using cellulose polymers. Mechanical testing showed that the printed films had Young's moduli and tensile strength values similar to the free film, while casted films were significantly more brittle. The drug also appeared to crystallize out of casted films during stress testing whereas printed films remained unchanged. The dissolution behavior of printed and cast films were similar, because of the rapid disintegration of the polymer. The conclusion is that printing resulted in a better film than casting because the drug resided on the film, rather than in the film where it could exert a plasticizing effect.

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“…The calculated values of Ea were of the same magnitude of those reported in the literature for water dispersions of hydrocolloids (Lee & Brant, ; Marcotte, Taherian Hoshahili, & Ramaswamy, ). Interestingly, the values of Ea are almost double when determined for water dispersions of hydrocolloids in presence of high amount of cosolute (Nickerson, Paulson, & Speers, ) and of an order of magnitude higher for casted dry hydrocolloids (film), when the parameters were calculated using the glass transition as the reference temperature (Bisharat et al., ; Cespi, Bonacucina, Mencarelli, Casettari, & Palmieri, ; Lazaridou & Biliaderis, ; Soares, Lima, Oliveira, Pires, & Soldi, ).…”

Section: Resultsmentioning

confidence: 99%

Linear Viscoelastic Properties of Selected Polysaccharide Gums as Function of Concentration, pH, and Temperature

Fagioli

Pavoni

Logrippo

et al. 2018

Journal of Food Science

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Hydrocolloids have been intensively investigated due to their ability to modify the rheology of the system where they are employed. They find application as thickening and gelling agents in many food, cosmetic, and pharmaceutical preparations, due to their biocompatibility and biodegradability. The present study aims to provide an exhaustive and comprehensive viscoelastic characterization of a series of hydrocolloid formulations, as function of concentration, pH, and temperature. Glucomannan, xanthan gum, tara gum, guar gum, konjac gum, and gellan gum have been analyzed at two concentrations (0.5% w/w and 1.5% w/w), using three different pH conditions (pH 1.2, 5.5, and 6.8). Their viscoelastic properties have been monitored measuring the main rheological parameters, namely, storage modulus G′ and loss modulus G′′ as function of frequency, time, and temperature. The results obtained show a clear dependence of the linear viscoelastic properties of the systems on concentration and pH, while the temperature was not a critical factor. Glucomannan, xanthan gum, tara gum, and guar gum samples prepared in phosphate buffer (pH 6.8) at the final concentration of 1.5% (w/w) have been selected as the most promising systems for further investigations, exploring the possibility of combinations to improve the rheological properties. Practical Application Glucomannan, xanthan gum, tara gum, guar gum, konjac gum, and gellan gum have been chosen among the most common thickening agents derived from plants to perform a systematic investigation of the influence of pH, concentration, and temperature on the rheological properties of their water dispersions. The data obtained may be useful for further application of these hydrogels in the nutraceutical field as thickeners, texture modifiers, emulsifiers, stabilizers, and gelling agents.

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Dynamic mechanical thermal analysis of hypromellose 2910 free films

Cited by 29 publications

References 30 publications

Rheological and thermo-mechanical properties of Sepifilm–Sepisperse water dispersions and films

Rheological and thermo-mechanical properties of Sepifilm–Sepisperse water dispersions and films

Ink-jet printing versus solvent casting to prepare oral films: Effect on mechanical properties and physical stability

Linear Viscoelastic Properties of Selected Polysaccharide Gums as Function of Concentration, pH, and Temperature

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