Kinetic disposition of an aqueous formulation of alphacypermethrin applied to the dorsal mid-line of sheep with long wool and its effect on lice

Johnson, P. W.; Darwish, A.; Dixon, Rita D.; Steel, J.W.

doi:10.1016/s0020-7519(96)00135-x

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…Further support of lateral transport is given by Johnson et al (1996) where an aqueous formulation of α‐cypermethrin (50 mg/ml) was applied to dorsal midline from neck to tail of five sheep. Data for days 14 to 98 showed that a sample site 50 mm from dorsal midline consistently had the highest concentrations (5–30 times higher) of α‐cypermethrin (approximately 50–360 ppm) compared to the other two lower regions (<50 ppm).…”

Section: Chemical Residue Evidence Of Lateral Transportmentioning

confidence: 89%

“…Johnson et al (1995) conducted a study similar to the α‐cypermethrin study described above (Johnson et al, 1996); however, a xylene‐based or water‐based 14 C deltamethrin formulation (10 mg/ml per formulation) was applied to the dorsal midline of fine‐wool Merino sheep housed as a group in covered pens, and these sheep were shorn prior to application (Johnson et al, 1995). Instead of obtaining samples 50 mm from dorsal midline as the Johnson et al (1996) study, samples were obtained 10 mm from the midline. Deltamethrin concentrations in the blood were negligible, and there was 20–25 times more deltamethrin in the wool than the skin biopsy after 24 hr.…”

Section: Chemical Residue Evidence Of Lateral Transportmentioning

confidence: 99%

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Surface distribution of pyrethroids following topical application to veterinary species: Implications for lateral transport

Bäumer

Baynes

2020

Vet Pharm & Therapeutics

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Pyrethroids like permethrin have been used as topical formulations for their ectoparasiticidal effects since the 1970s. There are numerous efficacy studies in dogs and livestock animals that indicate a fast spread of pyrethroids after topical administration onto rather confined areas of the skin. Some studies correlate the efficacy against ticks, fleas or lice with concentrations of pyrethroids in hair and, less frequently, stratum corneum samples. It is often stated that lateral transport is responsible for the distribution of the pyrethroids over the body surface. With this review, we attempt to demonstrate evidence for lateral transport of pyrethroids after topical administration in dogs, cattle and sheep and to present data gaps that should be addressed in follow‐up studies.

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Section: Chemical Residue Evidence Of Lateral Transportmentioning

confidence: 89%

Section: Chemical Residue Evidence Of Lateral Transportmentioning

confidence: 99%

Surface distribution of pyrethroids following topical application to veterinary species: Implications for lateral transport

Bäumer

Baynes

2020

Vet Pharm & Therapeutics

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Animal Health Products

Reeves¹

2002

Encyclopedia of Agrochemicals

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A vast range of veterinary chemical products are used in the animal health sector. Those that control external parasites (ectoparasites) on domestic animals are known as ectoparasiticides and comprise two major groups—pesticides and systemic insecticides/acaricides. Ectoparasites of companion animals are a major cause of dermatologic problems in animals and act as vectors for various pathogens. Ectoparasites cause production losses in food‐producing animals that incur enormous costs to the livestock industry. The manifestations of ectoparasites on food‐producing animals include anemia; reduced production of meat, milk, and eggs; reduced quality and quantity of fleece; damage to hides (cattle grubs and cockle of sheep pelts from lice infestations); hypersensitivity reactions (to the itchmite Psorergates ovis of sheep); transmission of animal diseases (pinkeye of cattle, encephalitis of horses, anaplasmosis of cattle); and decreased resistance to other diseases. Presently, chemical treatment applied prophylactically, strategically, or tactically remains the main option for ectoparasite control.

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Pharmacology and Therapeutics

Page¹,

Hennessy²

2007

Diseases of Sheep

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Kinetic disposition of an aqueous formulation of alphacypermethrin applied to the dorsal mid-line of sheep with long wool and its effect on lice

Cited by 7 publications

References 13 publications

Surface distribution of pyrethroids following topical application to veterinary species: Implications for lateral transport

Surface distribution of pyrethroids following topical application to veterinary species: Implications for lateral transport

Animal Health Products

Pharmacology and Therapeutics

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