Kinetic Degradation Study of Ipragliflozin Coupled with MS/MS Structural Elucidation

Metabolism and Chemical Degradation of New Antidiabetic Drugs: A Review of Analytical Approaches for Analysis of Glutides and Gliflozins

“…In the study of Elhassan et al [ 34 ], IPRA degradation was studied under different stress conditions, i.e., acidic, basic, photolytic, oxidative, and thermal. These forced degradation experiments showed extensive degradation of IPRA under acidic, basic, and oxidative conditions, while high stability of IPRA under thermal and photolytic conditions occurred.…”

“…The structural elucidation of the major degradation product (IPRA-D1) ( Figure 13 ) showed the detachment of benzothiophene, producing 2-[4-fluoro-3-(hydroxymethyl)phenyl]-6-(hydroxyl methyl)oxane-3,4,5-triol. In the mass spectrometer, the cleavage of the sugar part of the glycoside by McLafferty rearrangement took place, giving the 1-propene-1,3-diol moiety and 1-[4-fluoro-3-(hydroxymethyl)phenyl]propane-1,2,3-triol (IPRA-D2) ( Figure 13 ) [ 34 ]. As was shown above, the cleavage of the sugar part of the glycoside was also shown above for DAPA [ 48 ].…”

“…[33] IPRA UPLC-UV: Hypersil Gold UPLC C18 column from Thermo Fisher Scientific (Waltham, MA, USA) (3 × 50 mm, 1.9 µm) and isocratic elution with 25 mM potassium phosphate of pH 3, adjusted using H 3 PO 4 and ACN (50:50, v/v), 0.6 mL/min; UV 230 nm.Triple quadrupole-MS/MS: positive ion mode; capillary voltage 3 kV and the sampling cone voltage 20 V; the source temperature 120 • C, the desolvation temperature 400 • C, desolvation gas flow rate 600 L/h [34]. …”

Electrochemical Sensor for Meropenem Therapeutic Monitoring in Human Plasma Based on Carbon Nanotubes Modified Basal Pyrolytic Graphite Electrode

“…In recent years, several HPLC-MS/MS papers have been published for the determination of various β-lactam antibiotics in human fluids but HPLC-MS/MS is an expensive technique in terms of capital and analysis costs, has a high maintenance cost as compared to other analytical tools and requires a skilled and trained person. 13 The major deterrents against the widespread of TDM especially in limited-resources region are the cost and instruments availability. Therefore, development of POC diagnostics that are simple, rapid, with minimum sample preparation, short analysis time, low LOQ, and adequate high LOQ will be very beneficial in the clinical practice.…”