Kinetic characteristics of monoamine oxidase and serum cholinesterase in several related rat strains

Bellin, Judith S.; Sorrentino, Joseph

doi:10.1007/bf00485998

Cited by 6 publications

(3 citation statements)

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“…However, differences of this order are likely to be within the physiological range of flux rates within any one rat, and indeed greater differences in 5-HT turnover have been reported in rats nominally of the same strain from different suppliers (Miller, Cox & Maickel, 1968, Tonge & Leonard, 1971. It had been predicted by others that 5-HT might be catabolised more rapidly in the brain of FH rats, since their brain MAO activity towards 5-HT as substrate was higher (Bellin & Sorrentino, 1974). Finally the results with reserpine indicate that the relative size of the reserpine releasable pool is similar in the FH and SD rats.…”

Section: Resultsmentioning

confidence: 99%

“…A small increase in turnover on the 5-HT and kynurenine pathways is suggested, but any relationship of this to the anecdotal behavioural differences (e.g. unusual docility -Bellin & Sorrentino, 1974) between FH and normal rats remain to be established. I thank Dr M. Brozovic (Epidemiology and Medical Care) for pointing out the possibility that brain 5-HT might be abnormal in Fawn-hooded rats.…”

Section: Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Brain Tryptophan Metabolism on the 5‐hydroxytryptamine and Kynurenine Pathways in a Strain of Rats With a Deficiency in Platelet 5‐ht

Joseph

1978

British J Pharmacology

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Brain 5‐hydroxytryptamine (5‐HT) metabolism has been compared in albino (Sprague‐Dawley; SD) and in Fawn‐Hooded (FH) rats, which have an inherited platelet 5‐HT deficiency. It was confirmed that blood 5‐HT levels in the FH rats were about one quarter of those in the SD rats. Brain 5‐HT and 5‐HIAA were however higher in FH rats on a per gram basis; there was no difference between the strains on a per brain basis, because of the smaller brain weights of the FH rats. Brain and plasma tryptophan were not significantly different in the two strains. Plasma kynur‐enine was higher in the FH rats, and brain kynurenine was also higher either on a per gram or on a per brain basis. The reserpine‐releasable brain 5‐HT was the same proportion of total brain 5‐HT in the two strains. Experiments with pargyline suggested that the turnover of 5‐HT was somewhat higher in the FH rats on a per gram basis, but not significantly so on a per brain basis. It is concluded that although brain tryptophan metabolism may be somewhat accelerated along both the 5‐HT and kynurenine pathways in the FH rats there is no gross deficiency in the binding of 5‐HT in their brains analogous to that found in their platelets.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%