An overview of the genetics of psychopathology

Petersen, Dennis R.; Collins, Allan C.; Miles, Rebecca G.

doi:10.1007/bf01065737

Cited by 2 publications

(1 citation statement)

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“…Mostly, hereditary factors are determinants of these differences. Identifying patients that carry these factors is very challenging to estimate their effect on the metabolic capacity following that adjust the therapeutic range of drugs doses accordingly (Swen et al, 2011, Mulder et al, 2021, van den Oord et al, 2007, Petersen et al, 1982. By identifying these patients, adverse drug reactions reduced and the response to treatment is improved.…”

Section: Introductionmentioning

confidence: 99%

Investigation of CYP3A4*22 polymorphism effects on the depressed treatment by citalopram and sertraline

Mohammadi

Beh-Pajooh

Ahmadimanesh

et al. 2022

Preprint

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Drug response variability due to interpersonal genetic differences is a new and vital research interest. Many single nucleotide polymorphisms (SNPs) have been characterized for CYP3A4 (alleles *1–*22). PCR-RFLP method performed to check CYP3A4*22 polymorphism as an important allele in drug metabolism. 45 Blood samples were collected from the Iranian population with the depressive disorder. Hamilton Depression Rating Scale (HAM-D) used for evaluate the severity of depression before and after 100 days of treatment. Among the individuals, 40 (91.2%) patients showed wild type (CC) and 5 (91.2%) patients were heterozygous (CT) for the CYP3A4*22 allele. Comparing the rate of decrease in HAM-D score between two genotypic groups in CYP3A4*22 showed a significant difference (p < 0.03). This comparison demonstrated that patients with heterozygote genotype of CYP3A4*22 have improved by SSRIs lower than wild-type of patients. It can be concluded that CYP3A4*22 genotype and dose adjustment can help improve drug treatment.

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Section: Introductionmentioning

confidence: 99%