Behavior and brain neurotransmitters: Correlations in different strains of mice

Krehbiel, Dwight; Bartel, Bonnie; Dirks, Marvin; Wiens, Wayne

doi:10.1016/s0163-1047(86)90872-1

Cited by 12 publications

(5 citation statements)

References 24 publications

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“…The awarding of the Nobel Prize in 1936 to Sir Henry Dale and Otto Loewi for their work on acetylcholine’s role in parasympathetic nervous system neurotransmission challenged the initial notion that neurons communicate through direct electrical transmission and set the foundation for the construction of a chemical-based novel for neurological function [ 45 ]. Early studies that show the correlation between animal behaviour [ 46 , 47 ] and the levels of brain chemicals, alongside observations that specific classes of drugs mimic the effects of chemical neurotransmission systems, further supported this proposition [ 48 ]. The development of methods to detect chemical release from neuronal axon terminals and evidence from neurophysiological measurements eventually confirmed the role of neurotransmitters in neurological function.…”

Section: Function Of Neuropeptides In the Neurological Systemmentioning

confidence: 99%

Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases

Yeo

Cunliffe

et al. 2022

Biomedicines

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Despite recent leaps in modern medicine, progress in the treatment of neurological diseases remains slow. The near impermeable blood-brain barrier (BBB) that prevents the entry of therapeutics into the brain, and the complexity of neurological processes, limits the specificity of potential therapeutics. Moreover, a lack of etiological understanding and the irreversible nature of neurological conditions have resulted in low tolerability and high failure rates towards existing small molecule-based treatments. Neuropeptides, which are small proteinaceous molecules produced by the body, either in the nervous system or the peripheral organs, modulate neurological function. Although peptide-based therapeutics originated from the treatment of metabolic diseases in the 1920s, the adoption and development of peptide drugs for neurological conditions are relatively recent. In this review, we examine the natural roles of neuropeptides in the modulation of neurological function and the development of neurological disorders. Furthermore, we highlight the potential of these proteinaceous molecules in filling gaps in current therapeutics.

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Section: Function Of Neuropeptides In the Neurological Systemmentioning

confidence: 99%

Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases

Yeo

Cunliffe

et al. 2022

Biomedicines

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“…[ 1 , 2 , 3 , 4 ] Individual neurons transmit information using chemical and electrical signals, and are organized in groups or circuits involved in different functions. [ 3 , 5 , 6 ] The electrochemical interactions of neuronal ensembles result in electrical activity emerging from the brain, which can show synchrony across populations in the form of brain rhythms and waves that propagate [ 7 , 8 , 9 ] or asynchronous discharges, depending on the brain state. [ 10 ] Different brain states (slow wave sleep, REM, wakefulness, anesthesia, etc.)…”

Section: Introductionmentioning

confidence: 99%

“…All perceptions, memories, and behaviors are based on the communication between the billions of neurons that constitute the brain. [1][2][3][4] Individual neurons transmit information using chemical and electrical signals, and are organized in groups or circuits involved in different functions. [3,5,6] The electrochemical interactions of neuronal ensembles result in electrical activity emerging from the brain, which can show synchrony across populations in the form of brain rhythms and waves that propagate [7][8][9] or asynchronous discharges, depending on the brain state.…”

Section: Introductionmentioning

confidence: 99%

Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist

et al. 2021

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The ability to control neural activity is essential for research not only in basic neuroscience, as spatiotemporal control of activity is a fundamental experimental tool, but also in clinical neurology for therapeutic brain interventions. Transcranial-magnetic, ultrasound, and alternating/direct current (AC/DC) stimulation are some available means of spatiotemporal controlled neuromodulation. There is also light-mediated control, such as optogenetics, which has revolutionized neuroscience research, yet its clinical translation is hampered by the need for gene manipulation. As a drug-based light-mediated control, the effect of a photoswitchable muscarinic agonist (Phthalimide-Azo-Iper (PAI)) on a brain network is evaluated in this study. First, the conditions to manipulate M2 muscarinic receptors with light in the experimental setup are determined. Next, physiological synchronous emergent cortical activity consisting of slow oscillations-as in slow wave sleep-is transformed into a higher frequency pattern in the cerebral cortex, both in vitro and in vivo, as a consequence of PAI activation with light. These results open the way to study cholinergic neuromodulation and to control spatiotemporal patterns of activity in different brain states, their transitions, and their links to cognition and behavior. The approach can be applied to different organisms and does not require genetic manipulation, which would make it translational to humans.

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“…All behaviors, thoughts, and emotions are rooted in the communication between the billions of neurons that constitute the brain. [1][2][3] Individual neurons transmit information using chemical and electrical signals, and are organized in groups or "circuits" that carry out a certain function. [3][4][5] The electro-chemical interactions of these groups of neurons produce synchronized electrical activity in the brain, called "brain waves" due to their periodic and propagating properties.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Individual neurons transmit information using chemical and electrical signals, and are organized in groups or "circuits" that carry out a certain function. [3][4][5] The electro-chemical interactions of these groups of neurons produce synchronized electrical activity in the brain, called "brain waves" due to their periodic and propagating properties. [6][7][8] They can be recorded by electroencephalography (EEG), and local field potential (LFP) measurements.…”

Section: Introductionmentioning

confidence: 99%

Control of brain state transitions with light

Almudena

Riefolo

Matera

et al. 2019

Preprint

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Human behavior is driven by specific neuronal activity and can be directly associated to characteristic brain states. The oscillatory activity of neurons contains information about the mental state of an individual, and the transition between different brain states is controlled by the neuromodulatory action of acetylcholine on nicotinic and muscarinic receptors. Manipulating brain waves bears high therapeutic interest in several neurological disorders, and can be achieved by transcranial direct current and magnetic stimulation techniques, and by optogenetics, although the clinical translation of the latter is hampered by the need of gene therapy. Here, we directly modulate brain waves with light using a photoswitchable muscarinic agonist. Synchronous slow wave activity can be disrupted in isolated cortical slices and in anesthetized mice. These results open the way to study the spatiotemporal distribution and the pharmacology of brain states, their transitions, and their links to cognition and behavior, in a diversity of wildtype organisms.

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Behavior and brain neurotransmitters: Correlations in different strains of mice

Cited by 12 publications

References 24 publications

Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases

Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases

Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist

Control of brain state transitions with light

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