Kinetic aspects of the solubilization of non-ionic monoalkyl amphiphile-cholesterol vesicles by octylglucoside

Bilayer Stability and Impermeability of Nonionic Surfactant Vesicles Sterically Stabilized by PEG–Cholesterol Conjugates

“…Longer storage duration induces an aggregation process. Indeed, as already found for NSV (12), while QELS MD are increasing with time, the HPLC-GEC elution profiles indicate preservation or slight decrease of the vesicle unit size (Table 1) proving the absence of vesicle fusion which would have led to a shift of the HPLC-GEC peaks toward the elution region of large particles. Whether it concerns DCP containing NSV or M-PEG-Chol based vesicles, the instability process is very progressive and likely affects a minority of vesicles over 3 months.…”

“…6. As previously described for the NSV-OG system (11,12), linear relationships are obtained and describe, at each break point, the partition of OG between the aqueous continuum and the aggregates according to the following equation:…”

“…Total OG concentration as a function of total lipid concentration that slow structural rearrangements of the lipids may occur at break points D (᭝, ᭡) and C (᭺, q) of the solubilization curves for within the vesicle membrane and contribute to the lowering bility, whether it is connected to such rearrangements or not, a The solubilization experiments were performed at an OG addition rate of 0.14 mmol/min. b Interpolated at 0.14 mmol/min from Seras et al (12).…”

“…Over the fortnight period following vesicle preparation, In the case of OG addition to NSV, the breaks in the variation of the sample turbidity indicate successive solubilipermeability coefficients (P) can be estimated, since particle size stability is verified and permeation rate constants ( k, zation stages (11)(12)(13)(14). In the vesicular domain delimited by point D, the insertion of OG molecules in the lipid bilayer Fig.…”

“…Comparison with conventional hydrophilic polymer chains has proved to be efficient in NSV stabilized by the negatively charged compound DCP their stabilization and has promoted them to potential long-has been systematically performed to define the optimum circulating drug carriers resistant to the reticuloendothelial level of PEG coating at which the physico-chemical propersystem (1)(2)(3)(4)(5)(6)(7)(8). In a previous study, we have been interested ties, previously explored for NSV (11)(12)(13)(14)(15), can be restored in such steric stabilization of nonionic surfactant vesicles or even improved. (NSV) based on a synthetic polyglycerol monoalkyl compound, diglycerol hexadecyl ether (C 16 G 2 ), and cholesterol.…”