Kinetic aspects of the silver ion release from antimicrobial polyamide/silver nanocomposites

Damm, Cornelia; Münstedt, Helmut

doi:10.1007/s00339-008-4434-1

Cited by 164 publications

(123 citation statements)

References 18 publications

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“…Survey and high resolution spectra were acquired at a detection angle of 45 using the Ka line of a standard aluminum and magnesium x-ray source, respectively, operated at 300 W. The curve fittings for the survey and high resolution Ag3d peaks were determined by means of least-squares using a Shirley background subtraction. All peak positions were normalized to that of the C1s peak, which was taken to be at 284.4 eV.…”

Section: B Plasma Deposition Of Thin Filmmentioning

confidence: 99%

“…There is a general consensus that the antibacterial properties of silver-containing films are due to its ionic Ag þ form, which are released from elemental silver particles via oxidative dissolution. 44,45 E. coli was selected as the test organism for the antibacterial activity assessment since it is a common hospital pathogen and a source of HAIs.…”

Section: B Antibacterial Activity Evaluationmentioning

confidence: 99%

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On the long term antibacterial features of silver-doped diamondlike carbon coatings deposited via a hybrid plasma process

et al. 2014

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Environmental surfaces are increasingly recognized as important sources of transmission of hospital-acquired infections. The use of antibacterial surface coatings may constitute an effective solution to reduce the spread of contamination in healthcare settings, provided that they exhibit sufficient stability and a long-term antibacterial effect. In this study, silver-incorporated diamondlike carbon films (Ag-DLC) were prepared in a continuous, single-step plasma process using a hybrid, inductively coupled plasma reactor combined with a very-low-frequency sputtering setup. The average Ag concentration in the films, ranging from 0 to 2.4 at. %, was controlled by varying the sputtering bias on the silver target. The authors found that the activity of Escherichia coli was reduced by 2.5 orders of magnitude, compared with the control surface, after a 4-h contact with a 2.4 at. % Ag-DLC coating. The coatings displayed slow release kinetics, with a total silver ion release in the sub-ppb range after 4 h in solution, as measured by graphite furnace-atomic absorption spectroscopy. This was confirmed by Kirby–Bauer diffusion tests, which showed limited diffusion of biocidal silver with a localized antibacterial effect. As a slow and continuous release is mandatory to ensure a lasting antibacterial effect, the newly developed Ag-DLC coatings appears as promising materials for environmental hospital surfaces.

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Section: B Plasma Deposition Of Thin Filmmentioning

confidence: 99%

Section: B Antibacterial Activity Evaluationmentioning

confidence: 99%

On the long term antibacterial features of silver-doped diamondlike carbon coatings deposited via a hybrid plasma process

et al. 2014

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“…However, this study describes an acrylic resin containing silver nanoparticles that can be used to produce dentures with antifungal properties. Silver nanoparticles have been used for their antimicrobial effect in different biomedical applications, 14 also in modifying commercial acrylic resins but not in the formulation of an experimental acrylic for denture bases. Silver nanoparticles are also reported to be nontoxic to humans and very effective against bacteria, viruses, and other eukaryotic micro-organisms at very low concentrations and without side effects.…”

Section: Introductionmentioning

confidence: 99%

“…15 For example, different concentrations of silver nanoparticles added to Lucitone 550 denture resin demonstrated an antimicrobial effect. 16 Although the literature reports various studies related to silver nanocomposites with antimicrobial applications in the medical field, 14 very few studies concerning addition of silver nanoparticles to denture base resins have been published. 17 A pilot study demonstrated that silver nanoparticle-loaded chemically cured resins made with silver benzoate 0.2% and 0.5% (w/w) which were tested in vitro for antibacterial activity against Streptococcus mutans.…”

Section: Introductionmentioning

confidence: 99%

Cytocompatible antifungal acrylic resin containing silver nanoparticles for dentures

Acosta-Torres¹,

Mendieta²,

Núñez-Anita³

et al. 2012

IJN

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Background: Inhibition of Candida albicans on denture resins could play a significant role in preventing the development of denture stomatitis. The safety of a new dental material with antifungal properties was analyzed in this work. Methods: Poly(methyl methacrylate) [PMMA] discs and PMMA-silver nanoparticle discs were formulated, with the commercial acrylic resin, Nature-Cryl TM , used as a control. Silver nanoparticles were synthesized and characterized by ultraviolet-visible spectroscopy, dispersive Raman spectroscopy, and transmission electron microscopy. The antifungal effect was assessed using a luminescent microbial cell viability assay. Biocompatibility tests were carried out using NIH-3T3 mouse embryonic fibroblasts and a Jurkat human lymphocyte cell line. Cells were cultured for 24 or 72 hours in the presence or absence of the polymer formulations and analyzed using three different tests, ie, cellular viability by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and cell proliferation by enzyme-linked immunosorbent assay BrdU, and genomic DNA damage (Comet assay). Finally, the samples were evaluated mechanically, and the polymer-bearing silver nanoparticles were analyzed microscopically to evaluate dispersion of the nanoparticles. Results:The results show that PMMA-silver nanoparticle discs significantly reduce adherence of C. albicans and do not affect metabolism or proliferation. They also appear not to cause genotoxic damage to cells. Conclusion:The present work has developed a new biocompatible antifungal PMMA denture base material.

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“…It is known that the ion release from nanocomposites occurs by corrosion and dissolution [37], [38]. Therefore, elemental nanoparticles or particles with minimal oxidation are favored as they constitute ion sources with potentially higher capacity.…”

Section: Introductionmentioning

confidence: 99%

Water-based, surfactant-free cytocompatible nanoparticle-microgel-composite biomaterials – rational design by laser synthesis, processing into fiber pads and impact on cell proliferation

et al. 2017

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Abstract:This work highlights the laser-based aqueous synthesis and processing of nanocomposites, composed of zinc or iron nanoparticles embedded in a N-Vinylcaprolactam microgel matrix, with potential applicability as ion releasing fiber pads for wound healing. An in situ laser process for microgel synthesis is developed and optimized for high embedded nanoparticle yields, evaluating influences of laser repetition rate and monomer concentration. The impact of the nanoparticles on polymerization was increased by embedded zinc oxide nanoparticles, and reduced in the presence of iron oxide. Furthermore, TEM images verified that the nanoparticles were homogeneously embedded into the polymer matrix. The nanoparticle-loaded microgels were thermally stable up to 429°C, which ensures that the composites maintain their integrity after heat sterilization and during rapid prototyping by thermal polymer processing. The general suitability of the hydrogels as active biomaterial for wound healing was assessed in toxicity, cell proliferation and migration assays using human dermal fibroblasts and keratinocytes, where cytocompatibility was verified, while the proliferation was affected by the gel alone as well as the embedded nanoparticles. The hydrogels were processed to suit their use as a biomaterial for wound coverages via electrospinning resulting in a centimeter scale fully cytocompatible fiber pad with the nanoparticle-filled microgel capsules supported on the fiber's surface.

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Kinetic aspects of the silver ion release from antimicrobial polyamide/silver nanocomposites

Cited by 164 publications

References 18 publications

On the long term antibacterial features of silver-doped diamondlike carbon coatings deposited via a hybrid plasma process

On the long term antibacterial features of silver-doped diamondlike carbon coatings deposited via a hybrid plasma process

Cytocompatible antifungal acrylic resin containing silver nanoparticles for dentures

Water-based, surfactant-free cytocompatible nanoparticle-microgel-composite biomaterials – rational design by laser synthesis, processing into fiber pads and impact on cell proliferation

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