Kimura Disease with Parotid Swelling and Cervical Lymphadenopathy: A Case Report and Literature Review

Dam, V Sha Kri Eh; Mohamad, Sakinah; Mohamad, Irfan

doi:10.5222/mmj.2020.84594

Cited by 3 publications

(2 citation statements)

References 12 publications

(19 reference statements)

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“…Local or systemic steroids can significantly reduce the mass and control the lesions, lymphadenopathy and nephrotic syndrome (17). Oral prednisolone has a high degree of individualization, and administered in different doses, durations and gradual reduction schemes according to the size of the primary or recurrent lesions (18)(19)(20). Even so, the mass also has recurrence after glucocorticoid reduction (about 45.8%) (21).…”

Section: Discussionmentioning

confidence: 99%

Case Report: A Rare Case of Nasal Forehead Mass in Kimura's Disease

Cao

2021

Front. Surg.

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Background: Kimura's disease is a rheumatic immune disease and head and neck lymph nodes are often involved. A mass occurring in the nasal forehead is rare. Good prognosis after surgical resection by glucocorticoid therapy is more rare.Case Summary: We report the rare case of a nasal forehead mass in a 45-year-old male patient with Kimura's disease. The patient underwent resection of the mass in October 2018 in a local hospital and the postoperative pathology was unclear. He then underwent a second resection in our department in December 2019 mainly because growth of the mass was affecting his appearance. Postoperative pathology confirmed that the patient had Kimura's disease, and he accepted systemic treatment with prednisone. We followed the patient for 10 months after surgery. He is now recovering well and continues to be closely monitored during follow-up.Conclusion: It is rare that the painless mass in the nasal forehead is diagnosed as a Kimura's disease.After completely resection of the mass and systemic treatment with prednisone, the patient had a good outcome. We provide experience for the treatment of Kimura's disease in nasal forehead.

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Section: Discussionmentioning

confidence: 99%

Case Report: A Rare Case of Nasal Forehead Mass in Kimura's Disease

Cao

2021

Front. Surg.

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“…Sometimes it also involves extracutaneous sites, such as salivary glands, lymph nodes, skin, and kidneys. It is endemic to Asia and tends to affect young men aged 20–40 years, with some sporadic cases in non-Asians [ 1 ]. Two characteristic laboratory examinations are peripheral eosinophilia and elevated serum immunoglobulin E (IgE) [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Kimura disease with Allergic Bronchopulmonary Aspergillosis: a case report

Fan

Chen

et al. 2022

Allergy Asthma Clin Immunol

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Background Kimura disease (KD) is a rare chronic idiopathic condition of unknown etiology that is prevalent in Asian males. It often causes subcutaneous lumps and enlarged lymph nodes, especially in head and neck region. But KD is also a systemic disease that can involve multiple organs, such as the kidneys and skin. Case presentation We report a 62-year-old Chinese man who presented with paroxysmal cough, enlarged inguinal lymph nodes, recurrent skin itching, and elevated IgE antibodies specific to A. fumigatus. After a comprehensive review, the final diagnosis for this patient was KD with Allergic Bronchopulmonary Aspergillosis (ABPA). Conclusions The age of onset and the location of the lump involved were not characteristic for the illness. This case report described the patient’s diagnosis and treatment process. This case report serves to arouse the attention of multidisciplinary team to explore the potential relationship between KD and ABPA. It will contribute to preventing the misdiagnosis and missed diagnosis of KD.

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Kimura's disease

Matchin¹,

Matz²

2023

Kazan Med J

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The analysis of published clinical observations on the diagnosis and treatment of patients with Kimura's disease, which is a rather rare chronic inflammatory disease of human soft tissues of unknown etiology, is presented. The onset of Kimura's illness is hardly noticeable. The disease proceeds sluggishly, with a varied clinical picture, most often with the formation of single or multiple subcutaneous nodules or tubercles and swelling in the head and neck on one or both sides. Other localizations of lesions are also described: limbs, orbit, eyelids, palate, pharynx, armpit, chest, inguinal region. The affected areas gradually increase in size over many months or years. Other clinical manifestations of Kimura's disease are presented in the form of edema of the extraocular muscle, juvenile temporal arteritis, sleep apnea in cases of damage to the larynx, and life-threatening coronary artery spasm in children. There are reports of other rare systemic clinical signs of Kimura's disease in the form of pruritus, eczema and rash. The disease is often associated with regional lymphadenopathy and/or salivary gland involvement, eosinophilia, and an increase in serum immunoglobulin E from 800 to 35,000 IU/mL. The disease may be accompanied by kidney damage in the form of glomerulonephritis and nephrotic syndrome. Most reported cases of Kimura's disease occur in young Asian men in their 20s and 30s, sporadically the disease is diagnosed in Europeans, North Americans, Caucasians, and Africans. Diagnosis of Kimura's disease is often clinically difficult. It is primarily based on excisional biopsy of the lesion or regional lymph nodes, and the histopathological findings are consistent regardless of the location of the lesion. Morphologically, Kimura's disease is characterized by the presence in biopsy specimens of such histological features as reactive follicular hyperplasia with prominent follicles surrounded by fibrous tissue. Interfollicular infiltrates are rich in plasma cells and eosinophils, which form diffuse eosinophilic microabscesses associated with granulomatous inflammation. The vessels are numerous, with an increase in postcapillary venules. At the same time, the blood vessels remain thin-walled, with cuboidal endothelial cells. Treatment issues are highlighted, and differences between Kimura's disease and angiolymphoid hyperplasia with eosinophilia are presented.

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Kimura Disease with Parotid Swelling and Cervical Lymphadenopathy: A Case Report and Literature Review

Cited by 3 publications

References 12 publications

Case Report: A Rare Case of Nasal Forehead Mass in Kimura's Disease

Case Report: A Rare Case of Nasal Forehead Mass in Kimura's Disease

Kimura disease with Allergic Bronchopulmonary Aspergillosis: a case report

Kimura's disease

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