Kimura Disease: CT and MR Imaging Findings

Park, S. W.; Kim, Hyung Jin; Sung, Ki-Bum; Lee, J. H.; Park, I. S.

doi:10.3174/ajnr.a2854

Cited by 68 publications

(83 citation statements)

References 17 publications

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“…Parka et al evaluated CT and MR imaging findings of KD in 28 patients, and they found a total of 52 non-nodal lesions in the head and neck. The parotid and periparotid area were the most frequent location of KD (69%), while the cheek area involvement was only 11.5% [6].…”

Section: Discussionmentioning

confidence: 99%

“…The lesions are commonly found in soft tissues, the major salivary glands with lymphnodes being frequently involved. Peripheral blood eosinophilia (10% -70%) and an elevated serum IgE level (800 -35,000 IU/ml) are seen [1,2,6]. Parka et al evaluated CT and MR imaging findings of KD in 28 patients, and they found a total of 52 non-nodal lesions in the head and neck.…”

Section: Discussionmentioning

confidence: 99%

“…SMAS is defined as one continuous and organized fibrous network in the face connecting the facial muscles with the dermis, and consists of a three-dimensional architecture of collagen fibers, elastic fibers, fat cells, and muscle fiber [5,14]. The lesions of KD tend to infiltrate into surrounding fat tissue [4,6], therefore, diffuse loss of T1-weighted normal hyperintensities of fat suggests that the lesions grow and infiltrate as if they replace the normal fat tissue. Malignant tumors in this area such as mu-coepidermoid carcinoma of accessory parotid gland tend to break SMAS and grow into deep space of the face [15].…”

Section: Discussionmentioning

confidence: 99%

“…However, complete resection is difficult because of infiltrative nature of the disease, and recurrence is common [2,7]. Other therapeutic options include irradiation therapy with or without systemic corticosteroids, cytotoxic agents, cyclosporine, and pentoxifylline [6,7]. Although this entity is a benign condition, the clinical course is often slowly progressive.…”

Section: Discussionmentioning

confidence: 99%

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MR imaging of cheek lesions of Kimura’s disease: Focusing on the signal abnormalities and the relationship with superficial musculoaponeurotic systems

Ukisu¹,

Kawahara²,

Hashizume³

et al. 2013

MRI

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Background and Purpose: Kimura's Disease (KD) is a rare benign chronic eosinophlic inflammatory disorder, characterized by angiolymphoid proliferation with peripheral eosinophilia and elevated serum immunoglobulin E. Most lesions occur in the head and neck regions. To the best of our knowledge, the relationship between subcutaneous cheek lesion of KD and the surrounding structures including superficial musculoaponeurotic systems (SMAS) has never been reported. The purpose of this study was to describe MR imaging findings of cheek subcutaneous lesion of KD and adjacent SMAS. Materials and Methods: Seven cheek subcutaneous lesions of 5 patients histopathologically proved KD were evaluated. We retrospectively evaluated the MR imaging findings of subcutaneous lesions for signal intensity in each imaging sequence, the border of the lesions, and appearance of SMAS. Results: All cheek lesions were displacing normal fat tissue. These lesions showed ill-defined border (7/7), slightly high signal intensity on T1-weighted images (7/7), and intermediate (1/7) or high signal intensity (6/7) on T2-weighted images. Cheek lesions were enhanced by intravenous injection of gadolinium to signal intensity close to that of fat tissue (3/4), and in one case, the avid enhancement of the mass was seen (1/4). All lesions attached to the outer surface of SMAS, however, only one out of 7 lesions distributed below the SMAS without tearing of the layers. SMAS below the lesion showed high signal intensity on T2-weighted images in two lesions (2/7). Conclusion: KD should be included in the differential diagnosis when a cheek mass presents with non-specific signal intensities and irregular border, which attaches to but does not interrupt SMAS on MR imaging.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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MR imaging of cheek lesions of Kimura’s disease: Focusing on the signal abnormalities and the relationship with superficial musculoaponeurotic systems

Ukisu¹,

Kawahara²,

Hashizume³

et al. 2013

MRI

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“…One of the largest case series to date notes the characteristic findings to be multiple ill-defined, enhancing lesions around the parotid gland, with associated lymphadenopathy [16]. Lymphoid nodules with discrete germinal centers can occupy an area extending from the reticular dermis to the fascia and muscle.…”

Section: Discussionmentioning

confidence: 99%

Kimura’s Disease—A Rare Cause of Head and Neck Swelling

Rao¹,

Kumar²

2014

IJOHNS

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Kimura's disease (KD) is a chronic inflammatory disorder with unknown etiology, most commonly manifesting as painless unilateral cervical lymphadenopathy or subcutaneous masses in the head or neck region. The disease is characterized by a triad of painless subcutaneous masses in the head or neck region, blood and tissue eosinophilia, and markedly elevated serum immunoglobulin E levels. Kimura's disease is an unusual vascular tumor that typically occurs at 20 to 30 years of age. There has been no documented case of malignant transformation; however, recurrence rates after excision may be as high as 25%. Surgery and medical therapy are useful for treatment. We present a 14 years old male developed a unilateral cervical mass associated with KD. It was a recurrence of disease. As a complete excisional resection of the mass already done 1 year back at some other centre, we decided to give medical treatment for Kimura's disease.

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A Painless Retroauricular Mass

Itamura

Swanson

2020

JAMA Otolaryngol Head Neck Surg

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Kimura Disease: CT and MR Imaging Findings

Cited by 68 publications

References 17 publications

MR imaging of cheek lesions of Kimura’s disease: Focusing on the signal abnormalities and the relationship with superficial musculoaponeurotic systems

MR imaging of cheek lesions of Kimura’s disease: Focusing on the signal abnormalities and the relationship with superficial musculoaponeurotic systems

Kimura’s Disease—A Rare Cause of Head and Neck Swelling

A Painless Retroauricular Mass

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