Kimchi methanol extracts attenuate hepatic steatosis induced by high cholesterol diet in low-density lipoprotein receptor knockout mice through inhibition of endoplasmic reticulum stress

Woo, Minji; Noh, Jeong Sook; Song, Yeong Ok

doi:10.1016/j.jff.2017.02.032

Cited by 14 publications

(26 citation statements)

References 46 publications

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“…The individual kimchi bioactive compounds that were previously identified by our team to be present in KME [ 15 ] were purchased from Sigma-Aldrich (St. Louis, MO, USA); namely, HDMPPA (CDS011403), quercetin (Q4951, purity ≥ 95%), ascorbic acid (A5960, purity ≥ 99%), and capsaicin (M2028, purity ≥ 95%). The KME was prepared for the present study as described below.…”

Section: Methodsmentioning

confidence: 99%

“…These effects of kimchi might be attributed to the antioxidative activity of its component bioactive compounds [ 14 ]. In our previous study, several bioactive compounds were identified from the kimchi methanol extract (KME); namely, ascorbic acid, capsaicin, 3-(4′-hydroxyl-3′,5′-dimethoxyphenyl)propionic acid (HDMPPA), and quercetin, at 280, 270, 40, and 20 mg/kg-KME, respectively [ 15 ]. Capsaicin, ascorbic acid, and HDMPPA are monophenol compounds, whereas quercetin is a polyphenol compound.…”

Section: Introductionmentioning

confidence: 99%

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Bioactive Compounds in Kimchi Improve the Cognitive and Memory Functions Impaired by Amyloid Beta

2018

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This study investigated the abilities of kimchi and its bioactive compounds to ameliorate amyloid beta (Aβ)-induced memory and cognitive impairments. Mice were given a single intracerebroventricular injection of Aβ25-35, followed by a daily oral administration of capsaicin (10 mg·kg-bw–1), 3-(4′-hydroxyl-3′,5′-dimethoxyphenyl)propionic acid (50 mg/kg bw), quercetin (50 mg/kg bw), ascorbic acid (50 mg/kg bw), or kimchi methanol extract (KME; 200 mg/kg bw) for 2 weeks (n = 7 per group). Carboxymethylcellulose was used as a vehicle for the normal and control groups. Behavioral task tests showed that the learning and memory abilities were significantly waned by the injected Aβ25-35, but these cognitive deficits were recovered by the administrated KME and kimchi bioactive compounds (p < 0.05). The reactive oxygen species, peroxynitrite, and thiobarbituric acid reactive substances levels were lower, and the glutathione level was higher, in the KME and bioactive compound groups than in the control group (p < 0.05). In the KME and bioactive compound groups, the protein expression levels of antioxidant enzymes (nuclear factor (erythroid-derived 2)-like 2-regulated superoxide dismutase-1 and glutathione peroxidase) were increased, whereas those of inflammation-related enzymes (nuclear factor-kappaB -regulated inducible nitric oxide synthase and cyclooxygenase-2) were decreased (p < 0.05). Thus, the antioxidative and anti-inflammatory properties of bioactive compounds-rich kimchi might help to attenuate the symptoms of Alzheimer’s disease.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds in Kimchi Improve the Cognitive and Memory Functions Impaired by Amyloid Beta

2018

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“…Furthermore, aortic apoptosis and plaque necrosis were tapered in mice (Ldlr -/- and Apoe -/- ) lacking the CHOP gene [ 4 31 ]. It is evident that antioxidants or natural products with antioxidative property like kimchi [ 7 11 ] would diminish ER stress in the aorta, which might retard the development of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…Mice fed HCD for 8 weeks together with oral administration of KME or distilled water. The dose of KME was 200 mg·kg-bw −1 ·day −1 , which we had previously exhibited health benefits in mice [ 11 ]. The body weight was measured weekly and food intake was monitored daily.…”

Section: Methodsmentioning

confidence: 99%

“…Health promoting effects of kimchi might be attributed to bioactive compounds present in kimchi. Our team previously identified ascorbic acid, capsaicin, 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid (HDMPPA), quercitrin, and quercetin in kimchi methanol extracts (KME), which amounts were 280, 270, 40, 30, and 20 µg/g-KME, respectively [ 11 ]. Lipid lowering and antioxidative effects of quercetin [ 12 ], capsaicin [ 13 ], ascorbic acid [ 14 ], and HDMPPA [ 15 16 ] have been cited.…”

Section: Introductionmentioning

confidence: 99%

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Kimchi attenuates fatty streak formation in the aorta of low-density lipoprotein receptor knockout mice via inhibition of endoplasmic reticulum stress and apoptosis

et al. 2017

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BACKGROUND/OBJECTIVESEndoplasmic reticulum (ER) stress is positively associated with atherosclerosis via elevating macrophage cell death and plaque formation, in which oxidative stress plays a pivotal role. Antioxidative, lipid-lowering, and anti-atherogenic effects of kimchi, a Korean fermented vegetable, have been established, wherein capsaicin, ascorbic acid, quercetin, 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid, and lactic acids were identified. In this study, mechanisms of action of kimchi methanol extracts (KME) on fatty streak formation via suppression of ER stress and apoptosis in aorta were examined in low-density lipoprotein receptor knockout mice.MATERIALS AND METHODSMice fed a high cholesterol diet with an oral administration of KME (KME group, 200 mg·kg-bw−1·day−1) or distilled water (control group) for 8 weeks (n = 20 for group). Plasma lipid and oxidative stress levels were evaluated. Protein expression was measured by western blot assay. Fatty streak lesion size and the degree of apoptosis were examined in the aorta.RESULTSCompared to the control group, in the KME group, plasma lipids levels were decreased and oxidative stress was alleviated (P < 0.05). Protein expression levels of nuclear factor (erythroid-derived 2)-like 2-mediated antioxidants in aorta were increased whereas those for ER stress markers, glucose regulated protein 78, phospho-protein kinase RNA-like ER kinase, phospho-eukaryotic initiation factor 2 subunit α, X-box binding protein 1, and C/EBP homologous protein were decreased in the KME group (P < 0.05). Moreover, apoptosis was suppressed via downregulation of phospho-c-Jun N-terminal kinase, bcl-2-associated X protein, caspases-9, and -3 with a concomitant upregulation of anti-apoptotic protein, B-cell lymphoma 2 (P < 0.05). Fatty streak lesion size was reduced and the degree of apoptosis was less severe in the KME group (P < 0.05).CONCLUSIONSIn conclusion, antioxidant activity of KME might prevent fatty streak formation through, in part, inhibition of ER stress and apoptosis in aortic sinus where macrophages are harbored.

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Preventative activity of kimchi on high cholesterol diet-induced hepatic damage through regulation of lipid metabolism in LDL receptor knockout mice

Woo

Noh

Park

et al. 2017

Food Sci Biotechnol

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This study investigated the effect of kimchi on hepatic lipid metabolism and inflammatory response. Low-density lipoprotein receptor knockout mice fed high cholesterol diet (HCD) with an oral administration of kimchi methanol extracts (KME, 200 mg kg bw day) or distilled water for 8 weeks (n = 10 per group). Compared with the control group, plasma and hepatic lipid concentrations were lower in the kimchi group ( < 0.05), which was confirmed with hepatic histological examination by Oil Red O staining. Hepatic expressions for fatty acid synthesis were downregulated whereas those for beta-oxidation were upregulated in the kimchi group ( < 0.05). Hepatic expressions for cholesterol synthesis were decreased but those for cholesterol export was increased in the kimchi group ( < 0.05). Moreover, kimchi intake reduced expression for inflammatory cytokines ( < 0.05). Kimchi exerted beneficial effects on HCD-induced hepatic damage by suppressing lipid synthesis and inflammation, and facilitating fatty acid oxidation and cholesterol excretion.

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Kimchi methanol extracts attenuate hepatic steatosis induced by high cholesterol diet in low-density lipoprotein receptor knockout mice through inhibition of endoplasmic reticulum stress

Cited by 14 publications

References 46 publications

Bioactive Compounds in Kimchi Improve the Cognitive and Memory Functions Impaired by Amyloid Beta

Bioactive Compounds in Kimchi Improve the Cognitive and Memory Functions Impaired by Amyloid Beta

Kimchi attenuates fatty streak formation in the aorta of low-density lipoprotein receptor knockout mice via inhibition of endoplasmic reticulum stress and apoptosis

Preventative activity of kimchi on high cholesterol diet-induced hepatic damage through regulation of lipid metabolism in LDL receptor knockout mice

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