Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt–Koyanagi–Harada syndrome in Japanese individuals

Levinson, Ralph D.; Okada, Annabelle A.; Ashouri, Elham; Keino, Hiroshi; Rajalingam, Raja

doi:10.1016/j.humimm.2009.11.001

Cited by 25 publications

(23 citation statements)

References 29 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results suggested that out of 14 activating and inhibitory KIR genes investigated, two activating genes, KIR2DS1 and KIR2DS5 seem to increase the risk of developing tuberculosis. Similar studies in Japanese cohort and Mestizo patients from southern California revealed that these two activating genes increased the risk of Vogt-Koyanagi-Harada syndrome [29,30]. KIR2DS1 can recognize Group 2 HLA-C, which consists of HLA-Cw2, -Cw4, -Cw5, -Cw6, and related alleles [31].…”

Section: Discussionmentioning

confidence: 63%

Killer cell immunoglobulin like receptor gene association with tuberculosis

Pydi¹,

Sunder²,

Venkatasubramanian³

et al. 2013

Human Immunology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 63%

Killer cell immunoglobulin like receptor gene association with tuberculosis

Pydi¹,

Sunder²,

Venkatasubramanian³

et al. 2013

Human Immunology

View full text Add to dashboard Cite

“…Figure 4 illustrates the KIR genotyping raw data for a set of 26 samples (S-1 to S-26) that we recently published [ 39 ]. We use this data set as an exemplar to describe data analysis methods (hereafter called the exemplar data set).…”

Section: Record the Results In A Microsoft Excel Spreadsheet Indicatingmentioning

confidence: 99%

“…This chapter describes the stepby-step protocol of PCR-SSP typing method for KIR genotyping. Moreover, using our previously published data set [ 39 ], we describe the basic rules to verify the accuracy of genotyping results and approaches for the data analysis.…”

Section: Introductionmentioning

confidence: 99%

Gene-Specific PCR Typing of Killer Cell Immunoglobulin-Like Receptors

Rajalingam

Ashouri

2013

Methods in Molecular Biology

Self Cite

View full text Add to dashboard Cite

By interacting with specifi c HLA class I molecules, the killer cell immunoglobulin-like receptors (KIR) regulate the effector function of natural killer (NK) cells and subsets of CD8 T cells. The KIR receptors and HLA class I ligands are encoded by unlinked polymorphic gene families located on different human chromosomes, 19 and 6, respectively. The number and type of KIR genes are substantially variable between individuals, which may contribute to human diversity in responding to infection, malignancy and allogeneic transplants. PCR typing using sequence-specifi c primers (PCR-SSP) is the most commonly used method to determine KIR gene content. This chapter describes a step-by-step protocol for PCR-SSP typing to identify the presence and absence of all 16 known KIR genes. Moreover, the chapter provides the basic rules to verify the accuracy of KIR genotyping results and explains specifi c methods for the data analysis.

show abstract

“…Polymorphisms of the cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene have been associated with susceptibility to VKH disease in the Chinese population [22]. Other work suggests that an activating KIR phenotype may predispose to the disease [53].…”

Section: Vogt-koyanagi-harada Diseasementioning

confidence: 99%

Intraocular Inflammation and Systemic Immune-Mediated Diseases

Smith¹,

Rosenbaum²

2011

CIR

View full text Add to dashboard Cite

Certain forms of uveitis, or intraocular inflammation, occur in association with systemic immune-mediated diseases. The specific location of the inflammation within the eye is often helpful in diagnosing an associated systemic disease, but it also provides clues to the pathogenic mechanisms of the ocular and systemic pathology. In this review we consider the most common uveitis-systemic disease associations. We describe clinical aspects of these diseases and discuss current concepts in relation to the pathogenesis of the ocular inflammation. By clarifying the basic mechanisms operating in these conditions, it may be possible to design disease-specific therapies to manage the ocular inflammation, as well as the associated systemic disease.

show abstract

Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt–Koyanagi–Harada syndrome in Japanese individuals

Cited by 25 publications

References 29 publications

Killer cell immunoglobulin like receptor gene association with tuberculosis

Killer cell immunoglobulin like receptor gene association with tuberculosis

Gene-Specific PCR Typing of Killer Cell Immunoglobulin-Like Receptors

Intraocular Inflammation and Systemic Immune-Mediated Diseases

Contact Info

Product

Resources

About