Kikuchi's Disease: A Case Report and Review of the Literature

Abstract

Kikuchi 's disease is a necrotizing lymphadenitis that is prevalent in Asia and is being increasingly recognized in other areas of the world. It usually occurs in women in their late 20s or early 30s and manifests as a posterior cervical adenopathy. It resolves spontaneously, usually over a period of severa l weeks to 6 months. Its initial clinical appearance is commonly similar to that of a lymphoma, and it can be pathologically misdiagnosed as such. Kikuchi 's disease might be associated with systemic lupus erythematosus. We report a case of Kikuchi 's disease that occurred in a 36-year-old Asian woman. We discuss the clinicalfeatures, differential diagnosis, radiographic evaluation, and pathology of this case, and we review the literature in an effort to assist otolaryngologists in diagnosing this benign and uncommon entity.

Fever of unknown origin (FUO) caused by Kikuchi's disease mimicking lymphoma

“…Nearly all patients have a self-limited illness requiring no specific therapy (Table I). [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] …”

Adverse Antibiotic-Induced Eruptions Associated With Epstein Barr Virus Infection and Showing Kikuchi-Fujimoto Disease-Like Histology

“…[8][9][10]57 Kikuchi-Fujimoto disease (KFD), also called histiocytic necrotizing lymphadenitis, is an idiopathic, self-limiting lymphadenopathy associated with a high fever, occurring most often in young women. 8,[57][58][59][60][61] In the lymph nodes, paracortical necrosis surrounded by foamy histiocytes, immunoblasts, and abundant karyorrhexis are the characteristic features. Skin involvement can occur in 16 to 40% of affected patients.…”

Kikuchi’s disease: A rare cause of cervical lymphadenitis and fever

“…Malaise, fatigue, myalgias, and heterogenous skin lesions are common extralymphatic manifestations. Nausea, vomiting, weight loss, diarrhea, night sweats, hepatosplenomegaly, headache, myocarditis, ataxia, and aseptic meningitis are rare (1,2,6,7).…”

“…A granulocytopenia with a lymphocytosis (50% of patients) and elevated C-reactive protein may be seen as well (5). Kikuchi's disease is typically diagnosed by lymph node biopsy, but fine-needle aspiration may be a less invasive diagnostic tool (7). It is the histopathologic findings that allow a distinction from other causes of lymphadenitis (1).…”

“…Kikuchi's disease does not respond to antibiotics and patients generally remain symptomatic for up to 6 months, although some cases have lasted for years (6,7). Rapid improvement has been noted after excisional biopsy, suggesting that the removal of the abnormal tissue contributes to the recovery (3).…”