Fever of unknown origin (FUO) caused by Kikuchi's disease mimicking lymphoma

Cunha, Burke A.; Mickail, Nardeen; Durie, Nicole; Pherez, Francisco M.; Strollo, Stephanie

doi:10.1016/j.hrtlng.2009.01.002

Cited by 10 publications

(5 citation statements)

References 23 publications

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“…Although considered idiopathic, several causes have been suggested, including neoplasia and infection (HIV, human herpesvirus 8, cytomegalovirus, Giardia, and hepatitis C, among others). 73,74 Awareness of this rare disease is important because of its propensity to mimic malignant lymphoma clinically.…”

Section: Kikuchi-fujimoto Diseasementioning

confidence: 99%

Mimics of Cutaneous Lymphoma

Sarantopoulos

Palla

Said

et al. 2013

American Journal of Clinical Pathology

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The Society for Hematopathology and European Association for Haematopathology workshop, from October 27 to 29, 2011, in Los Angeles, CA, exhibited many exemplary skin biopsy specimens with interesting inflammatory changes mimicking features of cutaneous lymphoma. This article reviews features observed in cutaneous lymphoid hyperplasia, cutaneous drug reactions, lupus-associated panniculitis, pityriasis lichenoides, hypereosinophilic syndrome, histiocytic necrotizing lymphadenitis, traumatic ulcerative granuloma with stromal eosinophils, and pigmented purpuric dermatosis, as well as a brief review of the pertinent literature and discussion of submitted conference cases. For the pathologist, it is important to be aware of diagnostic pitfalls as well as the limitations of ancillary testing (eg, clonality studies). Finally, correlation with total clinical information, good communication with clinical colleagues, close clinical follow-up with rebiopsy, and prudent use of laboratory studies are vital and will likely offer the best path toward a correct diagnosis.

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Section: Kikuchi-fujimoto Diseasementioning

confidence: 99%

Mimics of Cutaneous Lymphoma

Sarantopoulos

Palla

Said

et al. 2013

American Journal of Clinical Pathology

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“…The differential diagnosis of cervical adenopathy is extensive (Table) [1][2][3][4][5][6][7][8][9]. The diagnostic approach to bilateral cervical adenopathy is guided by clues suggested by the history, physical examination and routine laboratory studies.…”

Section: Discussionmentioning

confidence: 99%

Rosai-Dorfman Disease: An unusual cause of fever of unknown origin (FUO) and anterior cervical adenopathy in a child

Cunha

Durie

Selbs

et al. 2015

J Pediatr Infect Dis

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In children, cervical adenopathy and fever is a common diagnostic dilemma. We present an unusual case of fever with anterior cervical adenopathy mimicking lymphoma that was diagnosed by as Rosai-Dorfman disease (RD) by lymph node biopsy. RD disease typically presents in childhood with cervical adenopathy. Less commonly, RD may involve extra-nodal sites as well, including the skin (the most common extranodal site), central nervous system (CNS), eye, liver, spleen, pancreas, or kidney. Lymph node biopsy is diagnostic and to differentiates RD disease from other causes of lymphadenopathy such as lymphoma.

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“…Corticosteroids for example prednisone, has been suggested in severe cases or widespread Kikuchi disease. In some critical and complicated conditions, hydroxychloroquine is also being prescribed [15][16][17][18][19].…”

Section: Diagnosismentioning

confidence: 99%

A Recent Case Reports on Unfamiliar Kikuchi-Fujimoto Disease

Kaur¹,

Wani²,

Yadav³

et al. 2019

Med Clin Rev

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Kikuchi-Fujimoto Disease (KFD) is also known as Histiocytic Necrotizing Lymphadenitis. It is very rare, noncancerous and self-limiting Auto-Immune disease but mostly suspected as cancer, tuberculosis and systemic lupus erythematosus. It has symptoms such as cervical lymphadenopathy (enlargement of lymph nodes), low fever, headache, fatigue, night sweats and muscles pain. It typically affects young females aged between 20-35 years and mostly affects Asian populations. The main identification of KFD is characterized by Fine Needle Aspiration Cytology by taking blood sample from the swollen lymph node. Diagnosis is also possible with Fine Needle Aspiration Biopsy. Treatment for this disease has not been established. Non-steroidal Anti-Inflammatory Drugs or steroids are in use to ease the tenderness of lymph node and fever.

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Fever of unknown origin (FUO) caused by Kikuchi's disease mimicking lymphoma

Cited by 10 publications

References 23 publications

Mimics of Cutaneous Lymphoma

Mimics of Cutaneous Lymphoma

Rosai-Dorfman Disease: An unusual cause of fever of unknown origin (FUO) and anterior cervical adenopathy in a child

A Recent Case Reports on Unfamiliar Kikuchi-Fujimoto Disease

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