Kikuchi-Fujimoto lymphadenitis: role of parvovirus B-19, Epstein-Barr virus, human herpesvirus 6, and human herpesvirus 8

Rosado, Flavia; Tang, Yi‐Wei; Hasserjian, Robert P.; McClain, Colt M.; Wang, Beverly; Mosse, Claudio A.

doi:10.1016/j.humpath.2012.05.016

Cited by 53 publications

(51 citation statements)

References 22 publications

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“…However, no study in the literature has definitively proven a causal relationship between a virus and KFD or identified viral particles ultrastructurally. 1,3,17,18 Other infectious agents studied include Brucella, Bartonella henselae, Yersinia enterocolitica, Toxoplasma gondii, Entamoeba histolytica, and Mycobacterium szulgai. 3,18 It has been postulated that KFD represents an exuberant T-cell-mediated immune response to a variety of antigens in genetically susceptible people.…”

Section: Epidemiologymentioning

confidence: 99%

Kikuchi-Fujimoto Disease: A Review

Perry¹,

Choi

2018

Archives of Pathology &Amp; Laboratory Medicine

167

216

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Kikuchi-Fujimoto disease (KFD) is a rare entity characterized by subacute necrotizing lymphadenopathy and frequently associated with fever. Young adults of Asian ancestry are most commonly affected, but it has been reported worldwide. Despite many studies in the literature, the cause of KFD remains uncertain. Histologically, KFD is characterized by paracortical lymph node expansion with patchy, well-circumscribed areas of necrosis showing abundant karyorrhectic nuclear debris and absence of neutrophils and eosinophils. Three evolving histologic patterns—proliferative, necrotizing, and xanthomatous—have been recognized. By immunohistochemistry, histiocytes in KFD are positive for myeloperoxidase. There is a marked predominance of T cells in the lesions (with mostly CD8-positive cells) with very few B cells. The differential diagnosis of KFD includes infectious lymphadenitis, autoimmune lymphadenopathy (primarily systemic lupus erythematosus), and lymphoma. Clinicians and pathologists are poorly familiar with this entity, which frequently causes significant diagnostic challenges.

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Section: Epidemiologymentioning

confidence: 99%

Kikuchi-Fujimoto Disease: A Review

Perry¹,

Choi

2018

Archives of Pathology &Amp; Laboratory Medicine

167

216

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“…Viruses such as EBV, and human herpesvirus 6 and 8 have been shown to be associated with KFD based on serological studies,1 but none of these viruses have been shown to be causative, and the incidence of these viruses detected in patients with KFD are similar to control participants 9…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto disease presenting after consumption of ‘Miracle Mineral Solution’ (sodium chlorite)

Loh

Shafi

2014

BMJ Case Reports

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We present a case report of a 41-year-old woman of Malay ethnicity who presented with an 11-day history of fever and left-sided lymphadenopathy after consuming ‘Miracle Mineral Solution’ (sodium chlorite solution) for the first time. A diagnosis of Kikuchi-Fujimoto disease was established via lymph node biopsy after other differentials were excluded. The aetiology of Kikuchi-Fujimoto disease remains controversial, but viral, autoimmune and physicochemical causes have been suggested as possibilities. In this case, we hypothesise that oxidative injury from sodium chlorite initiated an inflammatory response, which triggered the onset of Kikuchi-Fujimoto disease.

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“…It is believed to be due to excessive immune response of histiocytes to infectious agents like the Epstein-Barr virus, cytomegalovirus, herpes virus and HIV [6]. Several authors have reported an association between KFD and autoimmune diseases, particularly SLE [7].…”

Section: Discussionmentioning

confidence: 99%

Kikuchi- Fujimoto Disease: A Rare Cause of Lymphadenopathy

Anuradha¹,

Vanlalmalsawmdawngliana²,

Khurana³

2017

JCR

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Background: Kikuchi-Fujimoto disease (KFD) also known as histiocytic necrotizing lymphadenitis is a rare and self-limiting cause of fever with lymphadenitis. It usually affects females of the reproductive age group with a predominant involvement of cervical lymph nodes. Case Report: We report a case of young boy with Kikuchi-Fujimoto disease who presented with prolonged fever and painless cervical lymphadenopathy. Conclusion: Due to numerous causes of lymphadenopathy, patients are likely to be misdiagnosed with another disease. A high clinical suspicion with histopathological confirmation is essential for early and accurate diagnosis of KFD, which is usually a self-limited condition.

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Kikuchi-Fujimoto lymphadenitis: role of parvovirus B-19, Epstein-Barr virus, human herpesvirus 6, and human herpesvirus 8

Cited by 53 publications

References 22 publications

Kikuchi-Fujimoto Disease: A Review

Kikuchi-Fujimoto Disease: A Review

Kikuchi-Fujimoto disease presenting after consumption of ‘Miracle Mineral Solution’ (sodium chlorite)

Kikuchi- Fujimoto Disease: A Rare Cause of Lymphadenopathy

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