Kif18A is involved in human breast carcinogenesis

Zhang, Chunpeng; Zhu, Changjun; Chen, Hongyan; Li, Linwei; Guo, Liping; Jiang, Wei; Lu, Shih Hsin

doi:10.1093/carcin/bgq134

Cited by 111 publications

(110 citation statements)

References 38 publications

Supporting

Mentioning

105

Contrasting

Order By: Relevance

“…The results revealed that KIF18A protein expression was significantly higher in breast cancer tissues than in normal breast tissues (21). This suggests that breast cancer cells may take advantage of KIF18A overexpression to control mitotic chromosome alignment and increase their rate of repetitive cell division.…”

Section: Kif18a Expression Ratio ------------------------------------mentioning

confidence: 92%

See 1 more Smart Citation

Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer

et al. 2016

View full text Add to dashboard Cite

Abstract. Recently, kinesin motor proteins have been focused on as targets for cancer therapy. Kinesins are microtubule-based motor proteins that mediate diverse functions within the cell, including the transport of vesicles, organelles, chromosomes and protein complexes, as well as the movement of microtubules. In the current study, the expression of kinesin family member 18A (KIF18A), a member of kinesin superfamily, was investigated in breast cancer using immunohistochemistry, and its effect on breast cancer prognosis was examined. KIF18A expression level was significantly associated with lymph node metastasis (P=0.047). In patients with high levels of KIF18A expression, survival was significantly poorer compared to patients with low levels of KIF18A expression (disease-free survival, P=0.030). Multivariate analysis revealed that venous invasion (hazard ratio, 9.22; 95% confidence interval, 3.90-23.66; P<0.001) and KIF18A expression (hazard ratio, 3.20; 95% confidence interval, 1.34-6.09; P=0.010) were independent predictive factors for lymph node metastasis. KIF18A may be a useful predictive marker for lymph node metastasis in breast cancer, which could facilitate curative adjuvant treatment.

show abstract

Section: Kif18a Expression Ratio ------------------------------------mentioning

confidence: 92%

“…It has been reported that KIF18A is involved in breast, colorectal and hepatocellular cancers, and cholangiocarcinoma (21)(22)(23)(24). However, there is essentially no information regarding the clinical relevance of KIF18A in breast cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Transfection and Generation of Stable Cell Lines-Transfection and establishment of stable cell lines were performed as described previously (24).…”

Section: Methodsmentioning

confidence: 99%

Involvement of S100A14 Protein in Cell Invasion by Affecting Expression and Function of Matrix Metalloproteinase (MMP)-2 via p53-dependent Transcriptional Regulation

Chen

Yuan

Zhang

et al. 2012

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

Background:The role of S100A14 in tumorigenesis and the underlying mechanisms have not been fully understood. Results: S100A14 affects cell invasiveness by regulating MMP2 transcription in a p53-dependent manner. Conclusion: S100A14 acts as either an inducer or an inhibitor of cell invasion depending on the p53 status of cells. Significance: These studies significantly increase our understanding of how S100A14 regulates cell invasiveness.

show abstract

“…Western blot analyses were performed as previously described (20). Antibodies used were anti-S100A14 (gifts of Dr. Iver Petersen, University Hospital Charite, Berlin, and Dr. Youyong L€ u, Beijing Cancer Hospital and Institute, Beijing) and anti-b-actin (A5316, Sigma).…”

Section: Western Blot Analysismentioning

confidence: 99%

S100A14: Novel Modulator of Terminal Differentiation in Esophageal Cancer

Chen

Sunkel

et al. 2013

Molecular Cancer Research

Self Cite

View full text Add to dashboard Cite

Aberrant keratinocyte differentiation is a key mechanism in the initiation of cancer. Because activities regulating differentiation exhibit altered or reduced capacity in esophageal cancer cells, it is vital to pinpoint those genes that control epidermal proliferation and terminal differentiation to better understand esophageal carcinogenesis. S100A14 is a member of the S100 calcium-binding protein family and has been suggested to be involved in cell proliferation, apoptosis, and invasion. The present study used immunohistochemistry analysis of S100A14 in clinical specimens of esophageal squamous cell carcinoma (ESCC) to show that decreased S100A14 is strongly correlated with poor differentiation. Furthermore, both mRNA and protein expression of S100A14 was drastically increased upon 12-O-tetra-decanoylphorbol-13-acetate (TPA) and calcium-induced esophageal cancer cell differentiation. Overexpression of S100A14 resulted in a G 1 -phase cell cycle arrest and promoted calcium-inhibited cell growth. Conversely, decreasing S100A14 expression significantly promoted G 1 -S transition and prevented the morphologic changes associated with calcium-induced cell differentiation. Molecular investigation demonstrated that S100A14 altered the calcium-induced expression of late markers of differentiation, with the most prominent effect on involucrin (IVL) and filaggrin (FLG). Finally, it was determined that S100A14 is transcriptionally regulated by JunB and that S100A14 and JunB status significantly correlated in ESCC tissue. In summary, these data demonstrate that S100A14 is transcriptionally regulated by JunB and involved in ESCC cell differentiation.

show abstract

Kif18A is involved in human breast carcinogenesis

Cited by 111 publications

References 38 publications

Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer

Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer

Involvement of S100A14 Protein in Cell Invasion by Affecting Expression and Function of Matrix Metalloproteinase (MMP)-2 via p53-dependent Transcriptional Regulation

S100A14: Novel Modulator of Terminal Differentiation in Esophageal Cancer

Contact Info

Product

Resources

About