Kidney Stones and the Risk for Chronic Kidney Disease

Rule, Andrew D.; Bergstralh, Eric J.; Melton, L. Joseph; Li, Xujian; Weaver, Amy L.; Lieske, John C.

doi:10.2215/cjn.05811108

Cited by 330 publications

(267 citation statements)

References 39 publications

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“…In a cohort of cystinuric patients, PCr appeared to increase with age (19). HBP and diabetes mellitus are risk factors for CKD in the general population (23) as well as in patients with nephrolithiasis (11,14,25,26). However, in a small series of cystinuric patients, it was reported that age and HBP were not significant risk factors for CKD (15).…”

Section: Discussionmentioning

confidence: 97%

“…The association between CKD and stones has been debated in many studies. The incidence and prevalence of CKD is significantly higher in patients with nephrolithiasis (11). However, the risk of CKD depends on the type of stones.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of HBP among patients with nephrolithiasis varies from 19.4% to 71.7% (11,14,35). HBP is poorly studied in cystinuric patients.…”

Section: Discussionmentioning

confidence: 99%

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CKD and Its Risk Factors among Patients with Cystinuria

Prot-Bertoye¹,

Lebbah²,

Daudon³

et al. 2015

Clinical Journal of the American Society of Nephrology

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Background and objectives Cystinuria is an autosomal recessive disorder affecting renal cystine reabsorption; it causes 1% and 8% of stones in adults and children, respectively. This study aimed to determine epidemiologic and clinical characteristics as well as comorbidities among cystinuric patients, focusing on CKD and high BP.Design, setting, participants, & measurements This retrospective study was conducted in France, and involved 47 adult and pediatric nephrology and urology centers from April 2010 to January 2012. Data were collected from 442 cystinuric patients.Results Median age at onset of symptoms was 16.7 (minimum to maximum, 0.3-72.1) years and median diagnosis delay was 1.3 (0-45.7) years. Urinary alkalinization and cystine-binding thiol were prescribed for 88.8% and 52.2% of patients, respectively, and 81.8% had at least one urological procedure. Five patients (1.1%, n=4 men) had to be treated by dialysis at a median age of 35.0 years (11.8-70.7). Among the 314 patients aged $16 years, using the last available plasma creatinine, 22.5% had an eGFR$90 ml/min per 1.73 m 2 (calculated by the Modification of Diet in Renal Disease equation), whereas 50.6%, 15.6%, 7.6%, 2.9%, and 0.6% had an eGFR of 60-89, 45-59, 30-44, 15-29, and ,15, respectively. Among these 314 patients, 28.6% had high BP. In multivariate analysis, CKD was associated with age (odds ratio, 1.05 [95% confidence interval, 1.03 to 1.07]; P,0.001), hypertension (3.30 [1.54 to 7.10]; P=0.002), and severe damage of renal parenchyma defined as a past history of partial or total nephrectomy, a solitary congenital kidney, or at least one kidney with a size ,10 cm in patients aged $16 years (4.39 [2.00 to 9.62]; P,0.001), whereas hypertension was associated with age (1.06 [1.04 to 1.08]; P,0.001), male sex (2.3 [1.3 to 4.1]; P=0.003), and an eGFR,60 ml/min per 1.73 m 2 (2.7 [1.5 to 5.1]; P=0.001).Conclusions CKD and high BP occur frequently in patients with cystinuria and should be routinely screened.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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CKD and Its Risk Factors among Patients with Cystinuria

Prot-Bertoye¹,

Lebbah²,

Daudon³

et al. 2015

Clinical Journal of the American Society of Nephrology

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“…However, clinical interpretations have mentioned not only an altering frequency and composition of urinary calculi but also a swing in gender and age-related incidences. Con tributing risk factors for kidney stones are obesity, insulin resistance and gastrointestinal pathology, living in warmer climates, and certain dietary patterns and medications [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Nephrolithiasis - An updated Review in Relation to Diagnosis, Prevention and Treatment

Kapoor¹,

Rb²,

Dadarwal³

2017

OAJTMR

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Nephrolithiasis or urinary stone disease is a common problem across the world. Ample of research is going on in expedition for extenuating this disease condition. The procedure of preparing stones in the kidney, bladder or urethra is called as Nephrolithiasis. Stones form twice as often in men as women. The characteristic of stones that impede the renal pelvis is unbearable, blinking pain that goes from the flank to the groin or to the genital area and inner thigh. Control diet, use of prescribed medicines, and proper nutrient use can assist in thwart the development of kidney stones. Obe¬sity surge the threat of kidney stones. However, diminish in weight could deterrence of kidney stones if taken with a high ani¬mal protein intake. A vigilant medical and dietary history, stone analysis, serologic tests, and urine analysis comprise the preliminary screening in patients who have been identified with stones. Computed tomography and multi detector computed tomography played vital role in exploration of choice for the characterization of urinary stone disease. The appearance of dual-energy CT has further armoured the pre-eminence of this modality over other imaging techniques in the management of nephrolithiasis. This review is an effort to revitalize the previous data available for nephrolithiasis, basically work on its diagnosis and healing and endow with comprehensive and up-to-date information on area under discussion. This article also put light on synthetic drugs and medicines accessible for the mitigation of nephrolithiasis in the internationally and also discuss a part mentioning risk factors and management of nephrolithiasis.

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“…The proportion of kidney stone disease associated with ESRD approximately 3.2%. 5 Very limited evidence suggests that there is a relationship between kidney stones and the development into CKD, 6 and the kidney stone is a risk factor of ESRD not be clear. 7 Relationship between kidney stone and kidney function loss show that there is absolute increase in renal adverse outcomes associated with kidney stones.…”

Section: Introductionmentioning

confidence: 99%

The Role of Glomerulosclerosis and Tubular Atrophy as Determining Factor for Reduced Kidney Function in Kidney Stone Disease

Oka

Widiana

2015

Bali Med J.

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Background: Kidney fibrosis including glomerulosclerosis (GS) and tubulointerstitial fibrosis (TIF) or tubular atrophy (TA) may be predictor of kidney dysfunction. Estimated glomerular filtration rate (eGFR) is a common laboratory examination to estimate the kidney function. The aim of this research is to determine relationship between histologic features namely glomerulosclerosis (GS) and tubular atrophy (TA), and estimated glomerular filtration rate (eGFR) in kidney stone disease. Methods: A cross-sectional study in a total of the 63 patients with kidney stone consisted of 25 (39.7 %) males and 38 (60.3 %) females, aged (51 ± 11 years), Blood urea nitrogen (BUN) 16 (8-62) mg/dl, serum creatinine 1.26 ( 0.47-6.76 ) mg/dl and eGFR 61.4 ± 32.1 ml/min. Histologic features showed GS index 6 (0-30) and TA index 892 ± 333. There was significant correlation between eGFR and GS index dan TA index(r -0,577; p=0.001 and 0,514;p = 0,001, consecutively). Multivariate regresion equations were eLFG = 67,21 -1.63 (GS index) and eLFG = 67,21 + 0,01 (TA index). Estimated GFR may be used as a marker of glomerulosclerosis and tubular atrophy in obstructive nephropathy of kidney stone patients.Keywords: kidney; fibrosis; filtration; glomerulosclerosis, tubular atrophy. INTRODUCTIONRenal fibrosis is a main feature of the microscopic anatomy of renal pathology, characterized by glomerulosclerosis (GS) and tubulointerstitial fibrosis or tubular atrophy (TA), with clinical manifestations of chronic kidney disease (CKD). This condition may progress to end-stage renal disease (ESRD) which required renal replacement therapy such as dialysis and kidney transplantation. The most common causes of CKD are glomerulonephritis, metabolic disease, obstructive nephropathy, interstitial nephritis and nephropathy diseases including cystic kidney disease.1 The incidence and prevalence of CKD in the world is on the rise, threatening to ESRD for the next decade, not all countries are able to overcome this problem. In the UK, the incidence and prevalence of ESRD approximately 10% and 60 %, in Europe an average 13 % and 70 %, and in the United States approximately 33 % and 140 %.

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Kidney Stones and the Risk for Chronic Kidney Disease

Cited by 330 publications

References 39 publications

CKD and Its Risk Factors among Patients with Cystinuria

CKD and Its Risk Factors among Patients with Cystinuria

Nephrolithiasis - An updated Review in Relation to Diagnosis, Prevention and Treatment

The Role of Glomerulosclerosis and Tubular Atrophy as Determining Factor for Reduced Kidney Function in Kidney Stone Disease

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