Kidney salvage using the fibrinogen- and thrombin-coated sponge TachoSil&lt;SUP&gt;®&lt;/SUP&gt; during nephron-sparing surgery for the resection of large renal tumours

Attar, Kaka Hama; Namasivayam, Jaya; Green, James; Peters, John

doi:10.1308/147870808x303001

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…A product that has been currently used and has shown effectiveness, safety and biocompatibility sponge is composed of fibrinogen and thrombin (Tachosil ® ). Some studies in the literature have supported its use [19,20].…”

Section: Discussionmentioning

confidence: 99%

Biopolymer Sponge for High Grade Renal Trauma: An Experimental Study in Rabbits

Tavares¹,

Vilar²,

Aguiar³

et al. 2014

OJU

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Introduction: Acute blunt or open renal trauma sometimes requires conservative measure which involves the use of specific materials in order to adequately restore renal parenchima. The purpose of this study is to analyze the effects of the sugar cane biopolymer sponge in an experimental model of renal trauma in rabbits. Methods: Experimental prospective study was paired with twelve New Zealand rabbits. After induction of renal trauma bilateral high-grade (grade 4-collecting system, according to AAST), the sugar cane biopolymer sponge was used for homeostasis and reconstruction of the right renal parenchyma (experimental group). The same procedure was performed in the left kidney, but using the Surgifoam ® sponge (Control Group). The animals were sacrificed after four weeks. Histological analysis was performed and the results were compared after statistically being evaluated. Results: Comparing the experimental group with the control, there was more inflammatory reaction and premature adhesions in the first one. Concerning the influence on efficacy and biocompatibility of the biopolymer, no serious complications like massive bleeding, haematoma, fistula or urinary stone formation were found in both groups. Conclusion: The sugar cane biopolymer sponge demonstrated good efficacy in relation to hemostatic control and reconstruction of the renal parenchyma without major complications. Future studies may direct its routine use in urologic practice.

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Section: Discussionmentioning

confidence: 99%

Biopolymer Sponge for High Grade Renal Trauma: An Experimental Study in Rabbits

Tavares¹,

Vilar²,

Aguiar³

et al. 2014

OJU

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“…Tagliabue et al [19] used TachoSil® in patients suffering from severe clotting disturbances in order to perform successful splenectomy and nephrectomy. Some other uses of the coated patch have also been reported: hepatic surgery (liver resection, liver transplantation), urologic surgery (kidney tumor resection, repair of recurrent vesicovaginal fistula), cardiovascular surgery (reduction of postoperative pericardial effusions after aortic tube grafts, in addition to stitches to facilitate mechanical and biologic suture in aortic arch aneurysm repair), digestive surgery (gastrointestinal anastomoses), and neurosurgery (management of cerebrospinal fluid leak after surgical removal of pituitary adenomas) [20][21][22][23][24][25][26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Efficiency of TachoSil® to prevent postsurgical adhesion development on laparoscopic rat model

Nohuz¹,

Darcha

Moreno³

et al. 2009

Gynecol Surg

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The aim of this study was to evaluate the effectiveness of a fibrinogen and thrombin-coated hemostatic sponge (TachoSil®) in the prevention of postsurgical adhesions in a laparoscopic rat model and its histological effects on uterine and peritoneal parenchyma. Design was a prospective randomized blinded study. Setting was in International Laparoscopic Surgery Centre, ClermontFerrand, France. There were 100 sexually mature female Sprague-Dawley rats weighing 240 to 300 g and aged 6-8 weeks. A standardized severe surgical injury induced by scissors and 40-W bipolar coagulation in the rat uterine horn, corpus, and peritoneum was performed to induce adhesion formation. After trauma, group 1 (n=50) received no treatment and group 2 rats (n=50) received TachoSil® applied on injured areas. Twelve weeks after the procedure, repeat laparoscopy was performed and adhesions were scored according to their extent and severity. A hysterectomy and a peritoneal biopsy in the injured area were achieved by laparotomy in order to investigate on a possible earlier effect of TachoSil® on the uterine and peritoneal parenchyma in 49 rats of each group. TachoSil® group adhesion scores showed a significant decrease on the three injured areas: peritoneum (12.96 vs. 21.66), uterine horn (7.22 vs. 15.20), and uterine corpus (5.88 vs. 34.52). TachoSil® group also demonstrated a major decline of uterine fibrosis and inflammation. This study revealed that TachoSil®, an absorbable biomaterial, can reduce postoperative adhesions after laparoscopic surgery on a rat model. TachoSil® also prevents thermo-induced injuries on uterine parenchyma (less fibrosis and less inflammation).

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“…When possible, the kidney is folded together over thrombin-soaked gel foam and approximated with interrupted horizontal mattress sutures. TachoSil may be used to further reinforce the suture line [51]. Just as in UWTs, adrenalectomy is performed only when adrenal preservation does not appear to be technically feasible or would not accomplish oncologic control.…”

Section: Surgical Technique For Nss In Bwtsmentioning

confidence: 99%