Kidney Injury Molecule Levels in Type 2 Diabetes Mellitus

Aslan, Özgür; Demir, Metin; Köseoğlu, Mehmet

doi:10.1002/jcla.21976

Cited by 12 publications

(12 citation statements)

References 26 publications

(35 reference statements)

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“…Although our diabetic subject had different average age, duration of disease, race and socioeconomic status, the result had high consistency with other studies and also demonstrated that NGAL and KIM-1 appeared earlier in nephropathy. 15,16,27,28,31,[35][36][37][38][39] Sensitivity and specificity of urine NGAL and KIM-1 in early diagnostic diabetic nephropathy of our study were similar to other researches. 39,40 Kapoula et al had showed the pooled sensitivity and specificity among the different settings analyzed ranged from 0.42 (95% CI, 0.22-0.66) to 1.00 (95% CI, 0.99-1.00) and 0.72 (95% CI, 0.62-0.80) to 0.98 (95% CI, 0.50-1.00) in T2DM patients, respectively.…”

Section: Dovepresssupporting

confidence: 90%

<p>Evaluation of Urinary Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 as Diagnostic Markers for Early Nephropathy in Patients with Type 2 Diabetes Mellitus</p>

Quang¹,

Nguyet²,

Thao³

et al. 2020

DMSO

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The purpose of this study was evaluating the early diagnostic value of two specific tubular markers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) in diabetes nephropathy. Patients and Methods: Cross-sectional study was carried in three groups of patients from 10/2017 to 10/2018 in Military Hospital 103. Group I included 30 healthy peoples with estimated glomerular filtration rate (eGFR) >60 mL/min/1.73 m 2 and urine albumin creatinine ratio (uACR) <30 mg/g. Group II included 30 type 2 diabetic patients having uACR <30 mg/g, eGFR >60 mL/min/1.73 m 2. Group III included 30 type 2 diabetic patients having uACR >30 mg/g, eGFR >60 mL/min/1.73 m 2. Results: Urine KIM-1 and NGAL increased progressively from control group (57.29 ± 25.91 pg/mL; 25.71 ± 13.69 ng/mL) to the group of diabetic patients with uACR <30 mg/g (167.06 ± 44.01 pg/mL; 37.42 ± 10.89 ng/mL) and the group of diabetic patients with uACR ≥30 mg/g) (p < 0.05). There were moderate correlations between KIM-1 (r = 0.48, p < 0.05) and NGAL (r = 0.45, p < 0.05) with uACR. There was a mild correlation between KIM-1 and NGAL (r = 0.29, p < 0.05). KIM-1 and NGAL are the independent tests to detect diabetic nephropathy. The sensivity and specificity of KIM-1 with cutoff value of 174.95 pg/mL were 62.37% and 73.48%, respectively; the sensivity and specificity of NGAL with cutoff value of 35.2 ng/mL were 60.45% and 70.37%, respectively. Conclusion: KIM-1 and NGAL in urine are independent markers for early diagnostic diabetic nephropathy.

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Section: Dovepresssupporting

confidence: 90%

<p>Evaluation of Urinary Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 as Diagnostic Markers for Early Nephropathy in Patients with Type 2 Diabetes Mellitus</p>

Quang¹,

Nguyet²,

Thao³

et al. 2020

DMSO

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“…In previous studies on diabetic nephropathy, the relationship between albuminuria and uKIM-1 was not obvious. A weak positive correlation between ACR and uKIM-1 was found, but KIM-1 was increased even in patients with moderate albuminuria [13,25,26]. There is no evidence that in diabetic nephropathy albumin is toxic to proximal tubule cells.…”

Section: Discussionmentioning

confidence: 82%

Urinary Kidney Injury Molecule-1 but Not Urinary Neutrophil Gelatinase Associated Lipocalin Is Increased after Short Maximal Exercise

Wołyniec

Ratkowski²,

Urbański³

et al. 2017

Nephron

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Background and Aims: Urinary neutrophil gelatinase associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are markers of acute kidney injury. The albuminuria is a well-known abnormality after physical exercise. The aim of this study was to investigate changes in uNGAL and uKIM-1 after intensive exercise causing albuminuria. Methods: The study population consisted of 19 participants (10 males and 9 females). The mean age of participants was 35.74 years. All were fit amateur runners; the mean body mass index was 21.99 in females and 24.71 in males. The subjects underwent a graded treadmill exercise test (GXT) according to the Bruce protocol. Maximal oxygen consumption (VO₂max) was measured. Immediately before and after the test urine was collected. Urinary creatinine, albumin, NGAL, and KIM-1 were measured. Albumin to creatinine (ACR), KIM-1 to creatinine (KCR), and NGAL to creatinine (NCR) ratios were calculated. Results: The mean VO₂max was 53.68 in females and 59.54 mL/min/kg in males. Albuminuria and ACR were significantly higher after exercise. An increase in the ACR from 8.82 to 114.35 mg/g (p < 0.01) was observed. uKIM-1 increased significantly after exercise from 849.02 to 1,243.26 pg/mL (p < 0.05). KCR increased from 1,239.1 to 1,725.9 ng/g but without statistical significance (p = 0.07). There were no statistical changes in pre- and post-run uNGAL levels. There was no correlation between post-GXT albuminuria and uKIM-1. Conclusions: uKIM-1 is a very sensitive marker of kidney dysfunction. In our study, uKIM-1 increased significantly after a very short period of exercise. It is not clear if the increase in KIM-1 is caused by post-exercise albuminuria.

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“…A positive correlation exists between KIM-1 and MA as well as microalbumin/Creatinine ratio. [30] MA patients have significantly higher BP and duration of diabetes compared to normolabumin uric subjects. HDL-c was significantly lower in MA subjects while FPG, TGs, TC and VLDL-C were found to be marginally higher in microalbuminuric than normolabumin uric.…”

Section: Microalbuminuriamentioning

confidence: 84%

Kidney manifestations of diabetes mellitus – A Review

Swaminathan

Rajeswari²,

Mohideen³

2018

Int Jour of Biomed Res

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The prevalence of diabetes mellitus, especially T2DM is on the increase worldwide and in a developing country like India, as of date approximately 30 -40% are identified to have DM. Sedentary life style, obesity, increased BMI, insulin resistance, hyperlipidemia, delayed diagnosis, metabolic syndrome are some of the factors that lead to the development of DM. Extensive research have been conducted in this field and still more studies are being undertaken. The first organ affected in all uncontrolled DM patients is the kidney, followed by liver and cardiac. Kidney disease predominantly account for increased mortality among T2DM and is the main cause of CKD as well as DN. Treatment of CKD due to uncontrolled T2DM is still controversial because of the scarcity of evidence available. MA plays a significant role in screening pre and established DM. Increased levels of urate are identified as one of the metabolic disturbances in T2DM. This review article highlights the research findings during the last two decades on the manifestations of kidney disease in T2DM.

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Kidney Injury Molecule Levels in Type 2 Diabetes Mellitus

Abstract: In our study, KIM-1 levels were significantly different suggesting that urinary KIM-1 levels may be an early marker in patients with diabetic nephropathy. J. Clin. Lab. Anal. 00:1-6, 2016.

Cited by 12 publications

References 26 publications

<p>Evaluation of Urinary Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 as Diagnostic Markers for Early Nephropathy in Patients with Type 2 Diabetes Mellitus</p>

<p>Evaluation of Urinary Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 as Diagnostic Markers for Early Nephropathy in Patients with Type 2 Diabetes Mellitus</p>

Urinary Kidney Injury Molecule-1 but Not Urinary Neutrophil Gelatinase Associated Lipocalin Is Increased after Short Maximal Exercise

Kidney manifestations of diabetes mellitus – A Review

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