Kidney injury molecule-1: potential biomarker of acute kidney injury and disease severity in patients with COVID-19

Vogel, Manuel J.; Mustroph, Julian; Staudner, Stephan T; Leininger, Simon; Hubauer, Ute; Wallner, Stefan; Meindl, Christine; Hanses, Frank; Zimmermann, Markus; Maier, Lars S.; Jungbauer, Carsten; Hupf, Julian

doi:10.1007/s40620-021-01079-x

Cited by 18 publications

(15 citation statements)

References 36 publications

(56 reference statements)

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“…Elevated KIM-1 levels correlated with a decline in eGFR in a study including 4750 patients followed for more than 10 years 150 . Manuel J et al also found KIM-1 in patients with COVID-19 might provide additional value in recognizing AKI at an early stage of disease in a cohort of 80 patients with COVID-19 151 . However, AKI is serious when the concentration of KIM-1 in blood or urine increased.…”

Section: Kim-1mentioning

confidence: 95%

Emerging early diagnostic methods for acute kidney injury

Xiao¹,

Huang²,

Yang³

et al. 2022

Theranostics

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Many factors such as trauma and COVID-19 cause acute kidney injury (AKI). Late AKI have a very high incidence and mortality rate. Early diagnosis of AKI provides a critical therapeutic time window for AKI treatment to prevent progression to chronic renal failure. However, the current clinical detection based on creatinine and urine output isn't effective in diagnosing early AKI. In recent years, the early diagnosis of AKI has made great progress with the advancement of information technology, nanotechnology, and biomedicine. These emerging methods are mainly divided into two aspects: First, predicting AKI through models construct by machine learning; Second, early diagnosis of AKI through detection of newly-discovered early biomarkers. Currently, these methods have shown great potential and become an attractive tool for the early diagnosis of AKI. Therefore, it is very important to discuss and summarize these methods for the early diagnosis of AKI. In this review, we first systematically summarize the application of machine learning in AKI prediction algorithms and specific scenarios. In addition, we introduce the key role of early biomarkers in the progress of AKI, and then comprehensively summarize the application of emerging detection technologies for early AKI. Finally, we discuss current challenges and prospects of machine learning and biomarker detection. The review is expected to provide new insights for early diagnosis of AKI, and provided important inspiration for the design of early diagnosis of other major diseases.

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Section: Kim-1mentioning

confidence: 95%

Emerging early diagnostic methods for acute kidney injury

Xiao¹,

Huang²,

Yang³

et al. 2022

Theranostics

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show abstract

“…Hyperkalemia has been observed in 23% of patients with COVID-19 AKI and is often associated with metabolic acidosis [ 44 , 45 ]. Although urinary kidney injury molecule 1 (uKIM-1) was shown to be a predictor of mortality in COVID-19 AKI [ 46 ] and damage at the level of the podocyte and renal tubule is important [ 24 ], multiple factors may be associated with damage at the same site, making it difficult at this time to separate the cytopathic component of the virus from other pre-existing and associated morbid conditions.…”

Section: Clinical and Biochemical Manifestations Of Covid-19 Akimentioning

confidence: 99%

Acute Kidney Injury in COVID-19 Patients: Pathogenesis, Clinical Characteristics, Therapy, and Mortality

2022

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Coronavirus disease 2019 (COVID-19) is a disease caused by infection with the SARS-CoV-2 virus and has represented one of the greatest challenges humanity has faced in recent years. The virus can infect a large number of organs, including the lungs and upper respiratory tract, brain, liver, kidneys, and intestines, among many others. Although the greatest damage occurs in the lungs, the kidneys are not exempt, and acute kidney injury (AKI) can occur in patients with COVID-19. Indeed, AKI is one of the most frequent and serious organic complications of COVID-19. The incidence of COVID-19 AKI varies widely, and the exact mechanisms of how the virus damages the kidney are still unknown. For this reason, the purpose of this review was to assess current findings on the pathogenesis, clinical features, therapy, and mortality of COVID-19 AKI.

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“…Moreover, KIM-1 is also identified as a hepatitis A virus cell receptor 1 (HAVCR-1) that is expressed by on the surface of different epithelial cells and facilitates cellular entry of several viruses, including Ebola virus, dengue virus, West Nile virus, and hepatitis A virus, via the IgV domain [ 115 ]. A recent report suggested that KIM-1 was not only a biomarker for COVID-19-associated acute kidney injury (AKI) [ 116 ] but also a potential receptor for SARS-CoV-2. [ 7 ] SARS-CoV-2 was reported to directly infect the renal tubules by ACE2 and induced AKI, which is one of the most prevalent complications among hospitalized COVID-19 patients [ 117 ].…”

Section: Kim-1 and H 2 Smentioning

confidence: 99%

The Antiviral Roles of Hydrogen Sulfide by Blocking the Interaction between SARS‐CoV‐2 and Its Potential Cell Surface Receptors

Dai

Teng

Jin

et al. 2021

Oxidative Medicine and Cellular Longevity

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The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is posing a great threat to the global economy and public health security. Together with the acknowledged angiotensin-converting enzyme 2, glucose-regulated protein 78, transferrin receptor, AXL, kidney injury molecule-1, and neuropilin 1 are also identified as potential receptors to mediate SARS-CoV-2 infection. Therefore, how to inhibit or delay the binding of SARS-CoV-2 with the abovementioned receptors is a key step for the prevention and treatment of COVID-19. As the third gasotransmitter, hydrogen sulfide (H2S) plays an important role in many physiological and pathophysiological processes. Recently, survivors were reported to have significantly higher H2S levels in COVID-19 patients, and mortality was significantly greater among patients with decreased H2S levels. Considering that the beneficial role of H2S against COVID-19 and COVID-19-induced comorbidities and multiorgan damage has been well-examined and reported in some excellent reviews, this review will discuss the recent findings on the potential receptors of SARS-CoV-2 and how H2S modulates the above receptors, in turn blocking SARS-CoV-2 entry into host cells.

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Kidney injury molecule-1: potential biomarker of acute kidney injury and disease severity in patients with COVID-19

Cited by 18 publications

References 36 publications

Emerging early diagnostic methods for acute kidney injury

Emerging early diagnostic methods for acute kidney injury

Acute Kidney Injury in COVID-19 Patients: Pathogenesis, Clinical Characteristics, Therapy, and Mortality

The Antiviral Roles of Hydrogen Sulfide by Blocking the Interaction between SARS‐CoV‐2 and Its Potential Cell Surface Receptors

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