Kidney Disease and Youth Onset Type 2 Diabetes: Considerations for the General Practitioner

Dart, Allison; Sellers, Elizabeth; Dean, Heather

doi:10.1155/2012/237360

Cited by 11 publications

(12 citation statements)

References 82 publications

(97 reference statements)

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“…[77,78] Unfortunately, hypertension in youth is frequently overlooked due to the complexity of the BP% calculation requirements, inappropriate cuff size use, and vague hypertensive symptoms. [79–81] Target systolic (SBP) and diastolic BP (DSP) should be less than the 95 percentile based on age, gender and height using the “Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents” tables.…”

Section: Early Detection Of Hypertension and Microalbuminuriamentioning

confidence: 99%

“…Blood pressure lowering and RAAS blockade are critical early interventions to delay or prevent progression of MA and preserve kidney function. [77,78,48,83–86] Other factors that are independently associated with increased MA risk include cigarette smoking, hyperlipidemia and genetic susceptibility. [4, 87] Although data for youth with T2D is limited, stable MA or regression to normoalbuminuria in up to half of affected adults and youth with T1D can occur with aggressive management of glycemia, hyperlipidemia and RAAS blockade therapy.…”

Section: Early Detection Of Hypertension and Microalbuminuriamentioning

confidence: 99%

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Nephropathy in Youth and Young Adults with Type 2 Diabetes

Solis‐Herrera

Triplitt

Lynch³

2014

Curr Diab Rep

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The occurrence and progression of nephropathy associated with early onset type 2 diabetes is a consequence of the ongoing epidemic of childhood obesity. Minimal evidence regarding treatment effectiveness of renovascular comorbidities in youth with early onset T2D is available, due to the relatively recent emergence of T2D in youth and young adults. Extrapolation of adult therapy guidelines is not an ideal approach to making therapeutic decisions in this population. Evolving management and intervention strategies are based on accumulating longitudinal data from cohorts of well characterized youth and young adults with T2D. The degree of similarity in histologic findings and disease specific characteristics of kidney disease in patients with early onset T2D and albuminuria compared to affected adults is not well characterized. Early aggressive therapies to minimize the impact of nephropathy are indicated as the evidence for best therapies in youth with T2D are further explored.

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Section: Early Detection Of Hypertension and Microalbuminuriamentioning

confidence: 99%

Section: Early Detection Of Hypertension and Microalbuminuriamentioning

confidence: 99%

Nephropathy in Youth and Young Adults with Type 2 Diabetes

Solis‐Herrera

Triplitt

Lynch³

2014

Curr Diab Rep

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“…Kidney failure caused by either type 1 or type 2 DM is uncommon during childhood. Children with T2DM are at higher risk for developing primary renal disease (e.g., IgA nephropathy, membranoproliferative glomerulonephritis) [70,71] and a four-fold increased risk for developing renal failure [72]. Children with T2DM also have a high risk of ESRD during early adulthood [73].…”

Section: Renal Injurymentioning

confidence: 99%

Pediatric type 2 diabetes mellitus complications: a systematic review of the literature

Jordan¹,

Jordan²

2012

J Diab Res Clin Met

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The incidence and prevalence of type 2 diabetes mellitus (T2DM) are increasing worldwide in the pediatric population. The increase has been attributed to obesity, lack of physical activity, improper diet, and family medical history. Type 2 diabetes mellitus has serious complications for children, including cardiovascular problems, dyslipidemia, hypertension, nonalcoholic fatty liver disease, pancreatic problems, pulmonary problems, and renal injury. Unfortunately, T2DM and its complications in the pediatric population remain largely understudied. As such, diabetes researchers, educators, and clinicians are forced to rely on information collected on adults with T2DM which may or may not be applicable to children with T2DM.

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“…1,2 Since diabetes complications are closely related to the duration of diabetes and intensity of glycemic control, 3 young adults with early onset diabetes have increased risk of diabetes complications (and co-morbidities) during their productive years. 4–6 Early detection and intervention implementation to prevent diabetes progression are keys to improving health outcomes and quality of life as well as saving health care costs in diabetes care. 1,2 …”

Section: Introductionmentioning

confidence: 99%

A Self-assessment Tool for Screening Young Adults at Risk of Type 2 Diabetes Using Strong Heart Family Study Data

et al. 2016

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Purpose The purpose of this study is to characterize risk factors associated with type 2 diabetes in young adults ages 18–29 in order to develop a non-invasive risk assessment tool for use with younger American populations. Methods The self-assessment tool was developed using the Strong Heart Family Study data. A total of 590 young American Indian adults aged 18–29 (males=242) with normoglycemia and not receiving diabetes treatment were included. Risk factors recommended by the American Diabetes Association were used to assess diabetes risk in these young adults. A logistic regression model was developed to calculate the predicted probability. The area under receiver operating characteristic curve (AUROC) was used to evaluate the model. Results The final model showed that parental history of diabetes, obesity level, alcohol consumption, and high fasting glucose even within normal range were significantly associated with onset of prediabetes or diabetes in 5 years. The AUROC value was 0.68 with original and validated data, indicating the risk assessment tool had reasonably good discrimination ability. Conclusions This new non-invasive screening tool, based on data from American Indian young adults, has potential to screen young adults’ early-onset diabetes risk. Future studies are warranted to test this risk assessment tool in other racial/ethnic young adults.

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Kidney Disease and Youth Onset Type 2 Diabetes: Considerations for the General Practitioner

Cited by 11 publications

References 82 publications

Nephropathy in Youth and Young Adults with Type 2 Diabetes

Nephropathy in Youth and Young Adults with Type 2 Diabetes

Pediatric type 2 diabetes mellitus complications: a systematic review of the literature

A Self-assessment Tool for Screening Young Adults at Risk of Type 2 Diabetes Using Strong Heart Family Study Data

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