Kidney Disease and Epilepsy

Sazgar, Mona

doi:10.1016/j.jstrokecerebrovasdis.2021.105651

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…As reported, the recent reports from the WHO state that the renal diseases are the top 10th leading cause of death all over the world. The mortality due to the renal diseases have risen from 813,000 deaths in 2000 to 1.3 million deaths in 2019, posing serious to the human health [47].…”

Section: Evidence Of Copeptin In Modulating the Risk Of Renal Diseasesmentioning

confidence: 99%

RETRACTED ARTICLE: Review novel insights into the diagnostic and prognostic function of copeptin in daily clinical practice

Wang

et al. 2023

Mol Biol Rep

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As is shown in previous reports, arginine vasopressin (AVP), as one of the most important hormones within circulation in human beings, is of great clinically significance given that it could maintain the body fluid balance and vascular tone. However, the laboratory measurements AVP in daily clinical practice are shown to be difficult and with low accuracy. Concerning on this notion, it is unpractical to use the serum levels of AVP in diagnosing multiple diseases. On the other hand, another key serum biomarker, copeptin, is confirmed as the C-terminal of the AVP precursor which could be released in equal amounts with AVP, resultantly making it as a sensitive marker of arginine vasopressin release. Notably, emerging recent evidence has demonstrated the critical function of copeptin as a clinical indicator, especially in the diagnosis and prognosis of several diseases in diverse organs, such as cardiovascular disease, kidney disease, and pulmonary disease. In addition, copeptin was recently verified to play an important role in diagnosing multiple acute diseases when combined it with other gold standard serum biomarkers, indicating that copeptin could be recognized as a vital disease marker. Herein, in the current review, the functions of copeptin as a new predictive diagnostic and prognostic biomarker of various diseases, according to the most recent studies, are well summarized. Furthermore, the importance of using copeptin as a serum biomarker in diverse medical departments and the impact of this on improving healthcare service is also summarized in the current review.

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Section: Evidence Of Copeptin In Modulating the Risk Of Renal Diseasesmentioning

confidence: 99%

RETRACTED ARTICLE: Review novel insights into the diagnostic and prognostic function of copeptin in daily clinical practice

Wang

et al. 2023

Mol Biol Rep

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“…Not surprisingly, seizures were more common in our subgroup of patients with the poorest kidney function who required RRT. Approximately 10 % of patients with kidney failure and one-third of those with uremic encephalopathy develop seizures ( Sazgar, 2021 ). Although their incidence is unknown, seizures have been occasionally reported as the presenting symptom of COVID-19 infection ( Anand et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Use of remdesivir for COVID-19 pneumonia in patients with advanced kidney disease: A retrospective multicenter study

Stancampiano¹,

Jhawar²,

Alsafi³

et al. 2022

Clinical Infection in Practice

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“…Other areas for future research are briefly mentioned here. Kidney disease is associated with epilepsy 69 and end‐stage renal disease is associated with type 1 diabetes 70 . Inferences from these associations suggest that dysregulated Pi from impaired renal function might cause SERCA2a dysfunction related to sudden unexpected death in epilepsy (SUDEP), 71 and Pi‐induced SERCA2a dysfunction may be associated with dead‐in‐bed syndrome in type 1 diabetes 72 .…”

Section: Other Areas For Future Researchmentioning

confidence: 99%

Phosphate toxicity and SERCA2a dysfunction in sudden cardiac arrest

Brown

2023

The FASEB Journal

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Almost half of the people who die from sudden cardiac arrest have no detectable heart disease. Among children and young adults, the cause of approximately one-third of deaths from sudden cardiac arrest remains unexplained after thorough examination. Sudden cardiac arrest and related sudden cardiac death are attributed to dysfunctional cardiac ion-channels. The present perspective paper proposes a pathophysiological mechanism by which phosphate toxicity from cellular accumulation of dysregulated inorganic phosphate interferes with normal calcium handling in the heart, leading to sudden cardiac arrest. During cardiac muscle relaxation following contraction, SERCA2a pumps actively transport calcium ions into the sarcoplasmic reticulum, powered by ATP hydrolysis that produces ADP and inorganic phosphate end products. Reviewed evidence supports the proposal that end-product inhibition of SERCA2a occurs as increasing levels of inorganic phosphate drive up phosphate toxicity and bring cardiac function to a sudden and unexpected halt. The paper concludes that end-product inhibition from ATP hydrolysis is the mediating factor in the association of sudden cardiac arrest with phosphate toxicity. However, current technology lacks the ability to directly measure this pathophysiological mechanism in active myocardium, and further research is needed to confirm phosphate toxicity as a risk factor in individuals with sudden cardiac arrest. Moreover, phosphate toxicity may be reduced through modification of dietary phosphate intake, with potential for employing low-phosphate dietary interventions to reduce the risk of sudden cardiac arrest.

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Kidney Disease and Epilepsy

Cited by 7 publications

References 21 publications

RETRACTED ARTICLE: Review novel insights into the diagnostic and prognostic function of copeptin in daily clinical practice

RETRACTED ARTICLE: Review novel insights into the diagnostic and prognostic function of copeptin in daily clinical practice

Use of remdesivir for COVID-19 pneumonia in patients with advanced kidney disease: A retrospective multicenter study

Phosphate toxicity and SERCA2a dysfunction in sudden cardiac arrest

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