Ki-67 expression in early prostate cancer and associated pathological lesions.

Abstract

Aim-To assess cell proliferation in early prostate cancer and associated pathological lesions. Methods-Using the Ki-67 antibody, the cell proliferation index was measured in early stage prostatic carcinoma in 37 incidental tumours diagnosed at transurethral prostatectomy (TURP) and in 20 low volume cancers treated by radical prostatectomy. Proliferation indexes have also been measured in areas of normal peripheral zone, transition zone hyperplasia, atrophic appearing lobules, and high grade prostatic intraepithelial neoplasia in the radical prostatectomy cases. Results-In the TURP series the proliferation index correlated with grade and stage. Logistic regression analysis, however, showed that Gleason grade was the most reliable predictor of biopsy proven residual disease and clinical progression. In the radical series transition zone carcinoma the proliferation index was half that of peripheral zone carcinoma. The atrophic lobules also showed a high proliferation index of the same order as seen in the peripheral zone carcinoma. Normal peripheral zone showed the lowest proliferation index and in hyperplastic transition zone it was also less than the other areas.Conclusions-There is only limited support for the correlation of proliferation index with grade in early stage prostatic carcinoma. The findings do not suggest that proliferation index adds to the prognostic information given by grade and stage in pTl disease. The significant difference in proliferation index in transition zone and peripheral zone carcinomas supports the morphological distinction of these tumour types and is consistent with differences in biological behaviour. The high proliferation index in lobules considered morphologically atrophic is reminiscent of previous observations in which carcinoma was spatially associated with atrophy. (7 Clin Pathol 1996;49:741-748)

Utility of tissue microarrays MIB-1 for profiling prognostic biomarkers in clinically localized prostate cancer

“…Other authors demonstrated that positive expression of MIB-1 was correlated with higher rates of recurrence (7) . Feneley et al (15) observed that patients with adenocarcinoma showed rates of Ki-67 higher, with a significantly lower activity in tumors of the transition zone compared with the peripheral zone, which agrees with the less aggressive tumor of the first. The intraepithelial neoplasia showed value of Ki-67 intermediate between benign lesion and adenocarcinoma, showing the progression of proliferation with the change of prostatic parenchyma.…”

Ki-67 and outcome in clinically localised prostate cancer: analysis of conservatively treated prostate cancer patients from the Trans-Atlantic Prostate Group study

“…It has been investigated on TURP material (Feneley et al, 1996), biopsy material (Szende et al, 1999;Cowen et al, 2002;Ojea et al, 2004) and radical prostatectomy series (Bettencourt et al, 1996;Moul, 1999;Zudaire Bergera et al, 2000;Inoue et al, 2005) in large screening programmes (Laurila et al, 2009) and after radiation therapy . Some of these show that Ki-67 is an independent predictor of outcome on multivariate analysis .…”

Intermediate Cells in Human Prostate Epithelium Are Enriched in Proliferative Inflammatory Atrophy

“…[15][16][17][18] As glandular atrophy is often associated with chronic inflammation, the term proliferative inflammatory atrophy (PIA) was proposed for these lesions. 18 In that study, there was evidence that the atrophic luminal cells had an intermediate phenotype in that many cells expressed bcl-2 (normally a basal cell marker, in the prostate), and virtually all of the cells expressed high levels of keratins 8/18, as shown by staining with the CAM 5.2 monoclonal antibody.…”