Kheri (Acacia chundra, family: Mimosaceae) gum: Characterization
using analytical, mathematical and pharmaceutical approaches

Malviya, Rishabha; Sharma, Pramod Kumar; Dubey, Susheel Kumar

doi:10.17219/pim/76515

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…The polymer was soluble in hot water, swell to form a gel in cold water and insoluble in methanol, ethanol, benzene and acetone. Studies conducted on Artocarpus integer gum performed by Farooq et al and Malviya et al have also shown the same result and hence support this result [ 45 , 46 ].…”

Section: Resultssupporting

confidence: 73%

“…The viscosity of fluid decreases with an increase in temperature. The viscosity of liquid depends upon the strength of the attractive forces between the molecules that directly depends on their composition, shape, size and kinetic energy of the molecules, which directly depend on the temperature [ 46 ]. This is because when the temperature of the system is raised; energy is added effectively which gives the molecules of the liquid the required energy to overcome the intermolecular force.…”

Section: Resultsmentioning

confidence: 99%

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Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

et al. 2021

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Polymers from natural sources are widely used as excipients in the formulation of pharmaceutical dosage forms. The objective of this study was to extract and further characterize the tamarind gum polysaccharide (TGP) obtained from Tamarindus indica as an excipient for biomedical applications. Double distilled water was used as a solvent for the extraction of gum while Ethyl alcohol was used as an antisolvent for the precipitation. The results of the Hausner ratio, Carr’s index and angle of repose were found to be 0.94, 6.25, and 0.14, respectively, which revealed that the powder is free-flowing with good flowability. The gum was investigated for purity by carrying out chemical tests for different phytochemical constituents and only carbohydrates were found to be present. The swelling index was found to be 87 ± 1%, which shows that TGP has good water intake capacity. The pH of the 1% gum solution was found to be neutral, approximately 6.70 ± 0.01. The ash values such as total ash, sulphated ash, acid insoluble ash, and water-soluble ash were found to be 14.00 ± 1.00%, 13.00 ± 0.05%, 14.04 ± 0.57% and 7.29 ± 0.06%, respectively. The IR spectra confirmed the presence of alcohol, amines, ketones, anhydrides groups. The contact angle was <90°, indicating favorable wetting and good spreading of liquid over the surface The scanning electron micrograph (SEM) revealed that the particle is spherical in shape and irregular. DSC analysis shows a sharp exothermic peak at 350 °C that shows its crystalline nature. The results of the evaluated properties showed that TGP has acceptable properties and can be used as a excipient to formulate dosage forms for biomedical applications.

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Section: Resultssupporting

confidence: 73%

Section: Resultsmentioning

confidence: 99%

Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

et al. 2021

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“…Microwave-assisted free radical polymerization was carried out to synthesize KGP-g-Am. [10][11][12][13] Briefly, the polysaccharide and acrylamide solutions were prepared by dissolving KGP (1 g) and acrylamide (6 g) in 30 and 25 mL of water, respectively. Acrylamide solution was poured into the polysaccharide and stirred at 200 rpm for 1 h. CAN solution was prepared in water (Table 1).…”

Section: Methodsmentioning

confidence: 99%

“…It is also known as hydrocolloids. 10 Kheri plant is widely found in the Gujarat and Rajasthan regions of India. It is used as a substitute for Acacia gum.…”

Section: Introductionmentioning

confidence: 99%

Stabilization of Etoricoxib Nanosuspension Using Acacia chundra Gum and Copolymers: Preparation, Characterization, and In Vitro Cytotoxic Study

Malviya

Awasthi

Sharma

et al. 2021

ASSAY and Drug Development Technologies

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Present communication deals with the stabilization of etoricoxib nanosuspension using Acacia chundra gum and its acrylamidegrafted and carboxymethylated copolymers. Acrylamide grafting and carboxymethylation of A. chundra gum were carried out and synthesized copolymers were characterized. Ultrasound-assisted solvent-antisolvent method was utilized to co-precipitate the stabilizers over etoricoxib nanoprecipitates. A 3 2 full factorial design was used to evaluate the effect of independent variables, that is, the concentration of drug and stabilizer over the dependent variables, that is, particle size (PS), and entrapment efficiency (EE%) of nanoparticles. The effect of process parameters over super saturation, nucleation, and PS were studied and the role of mixing and ultrasound radiation was correlated. FTIR, DSC, and 1 H NMR analysis showed a significant difference between the copolymers. The application of stabilizers leads to the synthesis of small, spherical, no aggregated, and composite nanoparticles. PS growth analysis after 45 days showed no sign of ''Ostwald repining'' and aggregation. Optimized formulations prepared using A. chundra gum (formulation K9), acrylamidegrafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t 80 % in 190, 270, and 170 min, respectively. Cytotoxic studies showed that the formulation A8 had better control over cell growth than the pure drug against MCF-7 cell line. The results indicated that the A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.

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“…Subsequently, the concoction was subjected to rigorous agitation at 10-minute intervals for a duration of 60 minutes, followed by a 24-hour incubation period at ambient temperature. Following a 24-hour period, the quantity of powder was assessed for volume and subsequently utilized to determine the swelling index [11]. The formula 2 is used to determine the sweeling index.…”

Section: Loss On Dryingmentioning

confidence: 99%

Investigation of Physicochemical Properties, Phytochemical Constituents, Fluorescence Behavior, Extraction Methods, and TLC/HPTLC Analysis of Leaves From Amaranthus Cruentus: A Comprehensive Study

2023

ecb

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The aim of the study to investigate the Physicochemical analysis, Fluorescence analysis, Extraction, Phytochemical screening, Thin-layer chromatography (TLC) and High Performance thin-layer chromatography (HPTLC) of leaves of Amaranthus cruentus (A. cruentus). Physicochemical analysis, including the determination of various parameters such as loss on drying, swelling index, foaming index, total ash, acid-insoluble ash, water-soluble ash, extractive value, and fluorescence analysis was conducted on the powdered leaves. To extract the bioactive compounds, a Continuous hot Soxhlet apparatus was employed using solvents with increasing polarity, namely petroleum ether, chloroform, and ethyl acetate. Phytochemical screening was then performed on these extracts to identify the presence of various phytoconstituents. Thinlayer chromatography (TLC) and High-performance thin layer chromatography (HPTLC) were carried out exclusively on the ethyl acetate extract. The solvent system used for TLC and HPTLC was a mixture of toluene and ethyl acetate in a ratio of 7:3. HPTLC was performed with two marker compounds, Gallic acid, and Rutin, as these were the predominant phytoconstituents identified in the ethyl acetate extract. For the quantitative HPTLC analysis, a precoated silica gel 60 F254 plate was utilized, and UV detection was conducted at a wavelength of 254nm. This allowed for the precise determination of the amounts of Gallic acid and Rutin present in the ethyl acetate extract. The Physicochemical evaluation of powder indicated value of loss on drying was found 5.1%, swelling index value was 0.23%, the foaming index less than 100, total ash value was 11.86%, acid-insoluble ash value was 2.56%, water soluble ash value was 3.33% and pet. ether extractive value was 1.45%, chloroform extractive value was 1.21% and ethyl-acetate extractive value was 1.36%. In UV and visible light, many fluorescent colors were seen during fluorescence analysis. Pet. ether extraction value was 3.04%, chloroform extraction value was 3.41% and ethyl acetate extraction value was 3.64%. The preliminary phytochemical analysis of various extracts revealed the presence of alkaloids, carbohydrates, glycosides, amino acids, proteins, steroids, tannins and phenolics, saponins, flavonoids, fats, and oils. Additionally, TLC was performed on the ethyl acetate extract, resulting in the identification of seven unknown phytoconstituents. To further investigate the presence of specific compounds, HPTLC technique was employed. This technique enabled the detection and quantification of gallic acid and rutin. The Rf (retention factor) values obtained for gallic acid and rutin were 0.05 and 0.88, respectively. The amounts of gallic acid and rutin were determined to be 958.69 µg/100 mg and 107.65 µg/100 mg, respectively. These findings provide valuable insights into the composition and quantity of these compounds in the analyzed extract. The present physicochemical parameters, fluorescence, extraction, phytochemical, TLC and HPTLC study results could help in standar...

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Kheri (Acacia chundra, family: Mimosaceae) gum: Characterization using analytical, mathematical and pharmaceutical approaches

Abstract: Background. Natural polymers have been used in medical, pharmaceutical, cosmetic and food industry. They should be characterized before their possible applications in different industries.

Cited by 6 publications

References 7 publications

Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

Stabilization of Etoricoxib Nanosuspension Using Acacia chundra Gum and Copolymers: Preparation, Characterization, and In Vitro Cytotoxic Study

Investigation of Physicochemical Properties, Phytochemical Constituents, Fluorescence Behavior, Extraction Methods, and TLC/HPTLC Analysis of Leaves From Amaranthus Cruentus: A Comprehensive Study

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