Khat (Catha edulis) upregulates lipolytic genes in white adipose tissue of male obese mice (C57BL/6J)

Alshagga, Mustafa Ahmed; Mohamed, Zahurin; Seyedan, Atefehalsadat; Ebling, F. J.; Alshawsh, Mohammed Abdullah

doi:10.1016/j.jep.2020.113187

Cited by 11 publications

(10 citation statements)

References 38 publications

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“…Moreover, the bibliometric results noticed other properties of Catha edulis. High dose Catha edulis extract, cathinone, blocked the body weight gain of male mice on an obesity genic diet through upregulating lipolytic genes activity in white adipose tissue ( Alshagga et al, 2020 ). Cathine in Catha edulis acted as an effective weight loss agent for adjunct treatment of obesity with significant weight loss in overweight and obese patients ( Hauner et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Progress and Research Trends on Catha edulis (Vahl) Endl. (Catha edulis): A Review and Bibliometric Analysis

Liu

et al. 2021

Front. Pharmacol.

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Catha edulis (Vahl) Endl., known as Catha edulis or Khat is a traditional and regional plant for chewing, smoking and drinking, that has posed a worldwide public health problem due to its recent emerging abused consumption. In the face of the massive use of Catha edulis, we reviewed related publications to analyze the progress and research trends through bibliometric methods. After screening, a total of 514 scientific publications published from 1997 to 2020 were included by systematic retrieval from the Web of Science (WoS) database. According to further scientometric analysis, the annual number of publications output kept rising in most of the years. Ethiopia and the United States of America (USA) have been devoting significant contributions to the field. Though the research emphasis had been the chemical composition and pharmacological and toxicological effects for several years, the hot spots were transferred; the mechanism investigations of Catha edulis have been the focus in recent years, which might be continued in the future. Furthermore, co-operations of multi-disciplinary researchers are needed to minimize abuse harms and maximize the medicinal benefits of Catha edulis to human beings.

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Section: Discussionmentioning

confidence: 99%

Progress and Research Trends on Catha edulis (Vahl) Endl. (Catha edulis): A Review and Bibliometric Analysis

Liu

et al. 2021

Front. Pharmacol.

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“…Another study showed significant reducing effects of khat on TC, LDL-C, and HDL-C levels and elevated effect on TG levels in rabbits [57]. A more recent study on mice reported the decreased levels of TC and LDL-C in the group of mice treated with pure cathinone only rather than khat treated groups [58]. Those authors also concluded the unaffected levels of TC, LDL-C, and HDL-C after treatment with khat extracts for 8 weeks.…”

Section: Animals and In Vitro Studies It Has Been Demonstratedmentioning

confidence: 96%

“…Those authors also concluded the unaffected levels of TC, LDL-C, and HDL-C after treatment with khat extracts for 8 weeks. In addition, the hypotriglyceridemic effect of khat on mice was also observed [58]. One preliminary in vitro study estimated the reducing effects of khat extracts on TC and TG [59].…”

Section: Animals and In Vitro Studies It Has Been Demonstratedmentioning

confidence: 97%

Khat Chewing and Lipid Profile in Human and Experimental Animals

Al-Duais

Al-Awthan

2021

BioMed Research International

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Background. Catha edulis, also known as khat or qat, is a plant that grows in East Africa and southern Arabia. Several millions of people chew the leaves and twigs of khat plant for their central stimulating amphetamine-like effects. Khat chewing is becoming more common in Europe and the United States, owing to worldwide migration. Objective. This review examines the khat ingredients, global prevalence, and legal status as well as its effects on lipid profile. Methodology. A literature search was performed using PubMed, Scopus, and Google Scholar to collect information within articles published up to April 2021 with the goal of identifying relevant studies. The proposed mechanisms of cathinone effects on total cholesterol and triglyceride were also discussed. Conclusion. The khat chewing habit is considered as a serious economic and health issue that needs specialized programs to assist those people to quit or reducing this habit.

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“…In addition to cathinone and cathine, khat also contains other psychoactive components, particularly norephedrine, which has similar effects, although to a milder degree [9,10]. These naturally occurring psychoactive substances are reported to cause excitement, euphoria, increased alertness, and augmented restiveness [7,8,11]. According to prevalent traditional beliefs, Khat was reported to reduce appetite, obesity, and body weight [7,12,13].…”

Section: Introductionmentioning

confidence: 99%

“…These naturally occurring psychoactive substances are reported to cause excitement, euphoria, increased alertness, and augmented restiveness [7,8,11]. According to prevalent traditional beliefs, Khat was reported to reduce appetite, obesity, and body weight [7,12,13]. It is well known that amphetamine has appetite-suppressing properties, which may partially explain the low body mass index and malnutrition associated with amphetamine addiction.…”

Section: Introductionmentioning

confidence: 99%

Insights into the Anorexic Potential of Khat: An Integrated in vivo, ex vivo, and in silico Investigation

Jerah,

Taha,

Farasani

et al. 2024

Preprint

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Chewing khat (Catha edulis) releases cathine and cathinone, which may reduce appetite through an unknown mechanism. This study investigated the peripheral and central effects of fresh leaves and buds of C. edulis water extract (CEWE) on appetite and body weight, using in vivo, ex vivo, and in silico models. Rats of both sexes were used for three different experiments. Serotonin receptors were studied using isolated rat fundus samples and molecular docking. Significant differences in body weight were observed in the CEWE-treated groups compared with the controls over eight weeks. However, plasma leptin and ghrelin levels did not change significantly. The expression of the ghrelin and leptin genes was also unaffected, but the expression of the 5-HT gene decreased with CEWE treatment. CEWE antagonizes 5-HT receptors in isolated rat fundus samples. In silico docking indicated that the khat ligands inhibited 5-HT2C receptors. Cathine and cathinone levels in rat plasma were measured. These findings suggest that the appetite-suppressing role of khat can be attributed to its antagonistic effect on 5-HT receptors. Further research is needed to fully understand the mechanism of action of the khat extract. These findings provide a basis for future studies to validate and expand on these discoveries.

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Khat (Catha edulis) upregulates lipolytic genes in white adipose tissue of male obese mice (C57BL/6J)

Cited by 11 publications

References 38 publications

Progress and Research Trends on Catha edulis (Vahl) Endl. (Catha edulis): A Review and Bibliometric Analysis

Progress and Research Trends on Catha edulis (Vahl) Endl. (Catha edulis): A Review and Bibliometric Analysis

Khat Chewing and Lipid Profile in Human and Experimental Animals

Insights into the Anorexic Potential of Khat: An Integrated in vivo, ex vivo, and in silico Investigation

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