Progress and Research Trends on Catha edulis (Vahl) Endl. (Catha edulis): A Review and Bibliometric Analysis

Abstract

Catha edulis (Vahl) Endl., known as Catha edulis or Khat is a traditional and regional plant for chewing, smoking and drinking, that has posed a worldwide public health problem due to its recent emerging abused consumption. In the face of the massive use of Catha edulis, we reviewed related publications to analyze the progress and research trends through bibliometric methods. After screening, a total of 514 scientific publications published from 1997 to 2020 were included by systematic retrieval from the Web of Science (WoS) database. According to further scientometric analysis, the annual number of publications output kept rising in most of the years. Ethiopia and the United States of America (USA) have been devoting significant contributions to the field. Though the research emphasis had been the chemical composition and pharmacological and toxicological effects for several years, the hot spots were transferred; the mechanism investigations of Catha edulis have been the focus in recent years, which might be continued in the future. Furthermore, co-operations of multi-disciplinary researchers are needed to minimize abuse harms and maximize the medicinal benefits of Catha edulis to human beings.

Interpol Review of Drug Analysis 2019-2022

“…2020 Ethanolic extracts of young and mature leaves of three khat cultivars were subjected to GC-MS for hierarchical cluster analysis revealinig the existence of two major clusters where the extracts of young leaves were found to contain the maximum content of cathinone; however, methoxyamphetamine was found in only one extract of young leaves [ 328 ]; 2021 LC-MS/MS analysis of the concentration of cathinone and cathine from a seizure of fresh Khat leaves compared with two seizures of dried material [ 329 ]; systematic literature review of 514 scientific publications published from 1997 to 2020 to analyze research trends [ 330 ]; 2022 Khat use screening test [ 331 ].…”

Searching for coherence in a fragmented field: Temporal and keywords network analysis in political science

“…In addition to the adjustments described above for WKryx and applied to WK 2 , we also removed misleading keywords (multiple words glued together, words containing numbers, abbreviations, names of chemical compounds, or non-English language words, for example "iii" or "aa") by hand. This preprocessing step is widely used by bibliometric studies focused on keyword analysis (Rajasekharan et al, 2021;Ye et al, 2021;. Resulting network (WK 2 ryx) consisted of 115,378 writings and 25,355 keywords.…”

Khat chewing and its associated factors among pregnant women in Chiro district, eastern Ethiopia: a community-based study

“…Khat chewing is increasingly becoming a global public health threat ( 7 , 8 ). Advancing global market and increased production of the crop due to its ability to tolerate climate extremes have enhanced the accessibility and consumption of khat worldwide ( 8 , 9 ). The practice is widely prevalent in Eastern Africa and the Middle East ( 1 , 8 ).…”