Smectite clays occur in subduction zone fault cores at shallow depth (approximately 1 km; e.g., Japan Trench) and landslide décollements (e.g., Vajont, Italy, 1963). The availability of pore fluids affects the likelihood that seismic slip propagates from deeper to shallow fault depths or that a landslide accelerates to its final collapse. To investigate the deformation processes active during seismic faulting we performed friction experiments with a rotary machine on 2-mm-thick smectite-rich gouge layers (70/30 wt % Ca-montmorillonite/opal) sheared at 5-MPa normal stress, at slip rates of 0.001, 0.01, 0.1, and 1.3 m/s, and total displacement of 3 m. Experiments were performed on predried gouges under vacuum, under room humidity and under partly saturated conditions. The fault shear strength measured in the experiments was included in a one-dimensional numerical model incorporating frictional heating, thermal, and thermochemical pressurization. Quantitative X-ray powder diffraction and scanning electron microscopy investigations were performed on pristine and deformed smectite-rich gouges. Under dry conditions, cataclasis and amorphization dominated at slip rates of 0.001-0.1 m/s, whereas grain size sensitive flow and, under vacuum, frictional melting occurred at fast slip rates (1.3 m/s). Under partly saturated conditions, frictional slip in a smectite foliation occurred in combination with pressurization of water by shear-enhanced compaction and, for V = 0.01-1.3 m/s, with thermal pressurization. Pseudotachylytes, the only reliable microstructural markers for seismic slip, formed only with large frictional power (>2 MW/m 2 ), which could be achieved at shallow depth with high slip rates, or, at depth, with high shear stress in dehydrated smectites.