“…Table 3 shows most tumor cell lines (thyroid carcinoma cells ML-1 and ONCO-DG1, gastric carcinoma cells SGC-7901, U251 glioma cells, MDA-MB-231 breast cancer cells and BL6-10 melanoma cells) under SMG present the phenomenon of increased apoptosis [25, 36, 41, 44, 45, 47], but decreased apoptosis in MIP-101 poorly differentiated colorectal carcinoma ceils [19] and absence of obvious apoptosis in squamous cell carcinoma of the cervix (SCC) and ML-1 thyroid cancer are also observed [26, 109]. Cell cycle arrest, abnormal expression of apoptosis-related proteins (increased P21, P53, Fas and Bax; decreased the Bcl-2), tumor suppressor genes ( PTEN and P53 up-regulation) is often found in cancer cell lines [20, 25, 36, 41, 43, 45] (MDA-MB-231 and MCF-7 breast cancer cells, ML-1 and ONCO-DG1 thyroid carcinoma cells, DLD-1 colorectal cancer cells and U251 glioma cells) with increased apoptosis.…”