Key enzymes of degradation and angiogenesis as factors of tumor progression for squamous-cell cervical carcinoma

Solovyeva, N. I.; Timoshenko, O. S.; Kugaevskaya, E. V.; Andreeva, Yu Yu; Завалишина, Л Э

doi:10.1134/s1068162014060144

Cited by 6 publications

(7 citation statements)

References 24 publications

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“…Moreover, there is a close relationship between MET and MMPs [ 42 ]. In addition, it has been demonstrated that MMPs upregulate VEGF expression in endotheliocytes and tumor cells and promote interaction of VEGF and its receptors, inducing angiogenesis [ 43 ]. Therefore, there is a close relationship between MET, angiogenesis, and MMPs.…”

Section: Discussionmentioning

confidence: 99%

Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1α and autophagy in human osteosarcoma

et al. 2017

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Human osteosarcoma is considered a malignant tumor with poor prognosis that readily metastasizes. Tetrahydrocurcumin (THC) has been reported to have antitumor activity in numerous tumors. In addition, hypoxia-inducible factor-1α (HIF-1α) has been demonstrated to be associated with tumor metastasis by regulating epithelial-mesenchymal transition (EMT). However, the role of THC in osteosarcoma remains uncertain. Therefore, this study aimed to elucidate the potential mechanisms. We found that THC significantly reduced the growth of osteosarcoma cells and suppressed migration and invasion, as tested in a nude mouse lung metastasis model. Additionally, the mesenchymal-epithelial transition (MET) process was facilitated by THC. Mechanistically, our study showed that HIF-1α had a pivotal role in the antimetastatic effect of THC. Importantly, HIF-1α expression was downregulated by THC by inhibiting Akt/mTOR and p38 MAPK pathways. Moreover, THC exhibited a remarkable inhibitory effect on HIF-1α expression and angiogenesis under hypoxic conditions. Furthermore, THC activated autophagy and induced MET and suppressed angiogenesis in a HIF-1α-related manner. Taken together, our findings suggest that THC suppresses metastasis and invasion and this may be associated with HIF-1α and autophagy, which would potentially provide therapeutic strategies for human osteosarcoma.

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Section: Discussionmentioning

confidence: 99%

Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1α and autophagy in human osteosarcoma

et al. 2017

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“…MMP-2 and MMP-9 may be involved in the regulation of angiogenesis in tumor invasion and metastasis and may promote the release and migration of vascular endothelial cells from basement membrane (BM) by degradation of BM and ECM. MMP-2 can upregulate angiogenic cytokines through the following processes: (1) degradation of collagen IV, which exposes the binding sites of integrin α V β 3 and promotes the migration of endothelial cells [108]; (2) promoting the synthesis of VEGF and activating the inactive TGF- β ; (3) degradation of matrix components, release of basic FGF and VEGF combined with matrix components [109]; and (4) release of membrane-bound TNF- α and other cytokines that promote angiogenesis by the degradation of vascular BM. MMPs may also have adverse effects on tumor angiogenesis.…”

Section: Extracellular Proteinsmentioning

confidence: 99%

“…Table 3 shows most tumor cell lines (thyroid carcinoma cells ML-1 and ONCO-DG1, gastric carcinoma cells SGC-7901, U251 glioma cells, MDA-MB-231 breast cancer cells and BL6-10 melanoma cells) under SMG present the phenomenon of increased apoptosis [25, 36, 41, 44, 45, 47], but decreased apoptosis in MIP-101 poorly differentiated colorectal carcinoma ceils [19] and absence of obvious apoptosis in squamous cell carcinoma of the cervix (SCC) and ML-1 thyroid cancer are also observed [26, 109]. Cell cycle arrest, abnormal expression of apoptosis-related proteins (increased P21, P53, Fas and Bax; decreased the Bcl-2), tumor suppressor genes ( PTEN and P53 up-regulation) is often found in cancer cell lines [20, 25, 36, 41, 43, 45] (MDA-MB-231 and MCF-7 breast cancer cells, ML-1 and ONCO-DG1 thyroid carcinoma cells, DLD-1 colorectal cancer cells and U251 glioma cells) with increased apoptosis.…”

Section: Apoptosismentioning

confidence: 99%

Effect of Weightlessness on the 3D Structure Formation and Physiologic Function of Human Cancer Cells

Chen

Guo

et al. 2019

BioMed Research International

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With the rapid development of modern medical technology and the deterioration of living environments, cancer, the most important disease that threatens human health, has attracted increasing concerns. Although remarkable achievements have been made in tumor research during the past several decades, a series of problems such as tumor metastasis and drug resistance still need to be solved. Recently, relevant physiological changes during space exploration have attracted much attention. Thus, space exploration might provide some inspiration for cancer research. Using on ground different methods in order to simulate microgravity, structure and function of cancer cells undergo many unique changes, such as cell aggregation to form 3D spheroids, cell-cycle inhibition, and changes in migration ability and apoptosis. Although numerous better experiments have been conducted on this subject, the results are not consistent. The reason might be that different methods for simulation have been used, including clinostats, random positioning machine (RPM) and rotating wall vessel (RWV) and so on. Therefore, we review the relevant research and try to explain novel mechanisms underlying tumor cell changes under weightlessness.

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“…2 А1, А2). Эти данные согласуются с результатами более раннего исследования, в котором мы показали, что при ПКШМ наблюдается увеличение экспрессии ММП-9 в большинстве опухолей, а уровень экспрессии отражает метастатический и инвазивный потенциал опухоли [28]. Гиперэкспрессия ММП-9 в опухолях при ПКШМ была продемонстрирована также в ряде других исследований в тканях карцином шейки матки и образцах опухолей, находящихся на разных стадиях дифференцировки [29].…”

Section: Discussionunclassified

MMP-9, MMP-2, VEGF and VEGFR-2 as Factors of Invasion and Angiogenesis in Squamous Cell Carcinoma of the Cervix

Timoshenko

Kugaevskaya

2022

BMCRM

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Tissue destruction and angiogenesis play an important role in malignant tumor progression. They are responsible for the tumor growth and progress and its ability to invade and metastasize. The key role in the destructive processes belongs to matrix metalloproteinases (MMPs), which are able to cleave almost all components of the extracellular matrix (ECM). Gelatinases MMP-2 and MMP-9 hydrolyze type IV collagen, the main component of basement membranes, thereby releasing various biologically active molecules from ECM, including vascular endothelial growth factor (VEGF). VEGF is a key regulator of angiogenesis. The main mediator of the biological action of VEGF is its receptor VEGFR2. This study was aimed at assessing the relationship between the expression of the main factors of tissue destruction and angiogenesis - MMP-2, MMP-9, VEGF and VEGFR2 in the early and later stages of cervical squamous cell carcinoma (CSCC). The work was performed using samples of tumor and surrounding morphologically normal tissue, obtained from patients with or without metastases to regional lymph nodes. We have shown that MMP- 9 is significantly expressed in tumors in CSCC already at the early stages of tumor progression. At later stages of the disease (when metastases to regional lymph nodes are detected in patients), the expression of MMP-2, VEGF and VEGFR2 increases markedly both in the tumor and in the morphologically normal tissue surrounding the tumor and makes an additional contribution to the processes of destruction, angiogenesis and metastasis. We assume that MMP-2, VEGF and VEGFR2 can be considered as negative markers of the course of CSCC.

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Key enzymes of degradation and angiogenesis as factors of tumor progression for squamous-cell cervical carcinoma

Cited by 6 publications

References 24 publications

Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1α and autophagy in human osteosarcoma

Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1α and autophagy in human osteosarcoma

Effect of Weightlessness on the 3D Structure Formation and Physiologic Function of Human Cancer Cells

MMP-9, MMP-2, VEGF and VEGFR-2 as Factors of Invasion and Angiogenesis in Squamous Cell Carcinoma of the Cervix

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