Ketones from “white snakeroot” eupatorium urticaefolium

Natural Toxicants in Foods

“…The dotted area indicates the distribution of white snakeroot throughout the V.S. (Bonner and DeGraw, 1962;Bonner et al, 1961). There were three main ketones isolated from white snakeroot: dehydrotremetone, tremetone, and hydroxytremetone ( Fig.…”

“…These chemical groups inc1ude the coumarins, glycoalkaloids, isocoumarins, isoflavonoids, linear furanocoumarins, . Three main ketones isolated from white snakeroot (Bonner and DeGraw, 1962).…”

Naturally Occurring Benzofurans

“…22 The compounds, isolated from the ketone fraction, are toxic to goldfish and have been investigated from a structural viewpoint by degradative techniques with the findings that the principal toxic ketone is tremetone (23); the two other minor ketones are dehydrotremetone (24) and hydroxytremetone (17).2a-2s The related compound toxol, 26, was isolated by Zalkow and Burke26 from the rayless goldenrod, Aplopappw het eroph yllus. and its oxime, as well as thier two C-methyl groups and optical inactivity suggest this ketone is the completely unsaturated analog of tremetone (23). and its oxime, as well as thier two C-methyl groups and optical inactivity suggest this ketone is the completely unsaturated analog of tremetone (23).…”

Phytotoxic activities of (2R)-6-hydroxytremetone

“…Tremetones are benzofuran derivatives, which have been studied extensively because of their implications in toxic effects such as milk sickness [3], ketoacidosis in chicks [4], toxicity to goldfish [5], and allergenic activity [6]. However, beneficial effects such as bacterial growth inhibition, antitumor, and anti-HIV activities have been also reported [7e9].…”